Protein Alignment ca and glo-4

DIOPT Version :10

• Sequence 1: NP_733309.3
• Gene: ca / 43518
• FlyBaseID: FBgn0000247
• Length: 1961
• Species: Drosophila melanogaster
• Sequence 2: NP_505392.3
• Gene: glo-4 / 179306
• WormBaseID: WBGene00017195
• Length: 1386
• Species: Caenorhabditis elegans
• Alignment Length: 1564
• Identity: 311/1564 - (19%)
• Similarity: 515/1564 - (32%)
• Gaps: 592/1564 - (37%)

  Fly   474 STMGSFAIMDSPSVTPEPLGTTSGSFYNIQNLRSTFLLSALHSNSHSLTVHSIDISLKPLFVYKI 538
            :||..|| .||..|.  .|.||. |...:.|                 |.||:..|.|..|  |:
 Worm   287 ATMQFFA-ADSCGVV--ALDTTE-SIVEVYN-----------------TFHSLAHSSKRTF--KV 328

  Fly   539 PKHTQEILISSNILYGIHYVDLHCRSDSDHF-------------TAASLLDDPLVANTEKENRDA 590
            |..|..:....|:|:.:.. |...|| :.||             |:.:.....:||...:.::.|
 Worm   329 PPETWMVHAGDNMLFTVSN-DNEIRS-ALHFGFMSSRLEYTLVRTSTNWRPLGIVAMPSRPHKLA 391

  Fly   591 DIEKVDQSDVSAQKSDSTSATTTATSSLDQSDMPSTAINAVSVISSAMASLHTSDEDRFNNLAQL 655
            .|..|::..: .:...||:...|..:|.....:....:|:.||...|             |..::
 Worm   392 GIFVVNERGL-VRVEQSTALNLTKIASEFFFRLSPLQLNSKSVAQVA-------------NACRI 442

  Fly   656 GLFRFENETVLHLYQMAQYRNPSAEPETLTKEEKAKAFEL-KDIHTPM-DYIQFYETADVSSEFS 718
            ....|::..:.:|....:.|.       ||.:|.::.:.: |.|:..| |.::.:|...:..:..
 Worm   443 DTAEFQSALIPNLLSTRKNRQ-------LTNKELSQIYSIAKAINLSMSDLLKAFENESIGEQLL 500

  Fly   719 LRQMEIMQSEFPKINYDPSYVITNKNVYTIQLKKEPFELFLDAALQNEFNQCRDFCNTFDLSFEQ 783
            ...:..:|:...|  :|             .|.:...|:|:..:|..|.|.  |....:|...
 Worm   501 PEVLNTIQTNPAK--HD-------------NLMQRVVEMFVKRSLSAEGNM--DKIREYDAEL-- 546

  Fly   784 CIEFAGDYLLRRKKITQALLTYNKARVKPIRTALKLAMYGHTYALMQLSAMALKSTYLLRSRYLG 848
                 .::|.|.:.:.:..:...||           .|:..|..|::
 Worm   547 -----SNFLARHEHLHKGSVDCAKA-----------GMWKCTQTLVR------------------ 577

  Fly   849 HPLLKGILGDITYRHSEDVRVILPEKHEEEDVNSGVFCSDYHYGVDESISALQMSPSSQFHLANL 913
                            .||       ||.:             .:|.|...|            |
 Worm   578 ----------------RDV-------HETK-------------SIDTSTEVL------------L 594

  Fly   914 LLITLAEKAVNDKNYIPLWNFLVTNSKYHTNMTSIVLCQSGLFSSAIILAKIRGVCLDTFNALIS 978
            .:|         ||.:.:||  ..||.....:.|:| |.  |..|.:..|....||     |::|
 Worm   595 YII---------KNRLQIWN--EANSTDRLQIMSLV-CH--LDWSKLADADGARVC-----AILS 640

  Fly   979 VVAQEFGWYNELNVCLYNLSENIFLETITYLPHVSMDYFAFIQEKLHHIRPCVLQRLSKQLNPFS 1043
                  .|..::::..|:       |....:...:.|.|.         |||.:..|...::..|
 Worm   641 ------AWQRDISLPSYH-------EMCLRIAITNSDRFP---------RPCQILSLVSSIHILS 683

  Fly  1044 ----------PALRPIVSHNSDCAMSNDNNPQL-----FEFCKSLIETYLAVLIHMESQRVKYDS 1093
                      |...|:...| :|..:...:.:|     |...:..:|     :..|.::..:.||
 Worm   684 EKKISNHANLPNFLPLAGGN-NCGATITEDDRLMIWGNFTNAQQRME-----MPQMNAKSKRSDS 742

  Fly  1094 IVNALSNFRINYEDNQFAIESSRFKPISAGCAYCACVVDGTAYFWGSSGIPSYYSAQKSTEPPEP 1158
            :.|                                          |:..:|          ||.|
 Worm   743 VTN------------------------------------------GAPTLP----------PPAP 755

  Fly  1159 AHAVKSLDLLSQLNLQVHAIKCGRQHTLILTNNG-LYSLGNNNLCQLGIGRHMQMALQPMLVTAL 1222
            ........:|.....:..||.||.:|.|:|:::| |.:.|.|...|.|:|...::|    .:..:
 Worm   756 KPEQHLPRVLEYPGGRPRAIACGAEHILVLSSSGQLSAWGGNRFGQCGVGHSFRIA----NLHQV 816

  Fly  1223 DG--MNITMLEAGQYHNAAV-ADGKLYMWGWGIYGQLGQGSCENIATPQLVSF---FKFKKILQI 1281
            ||  ..|..:..||:|:|.: :||.|:.:|||::||||.|...|  :.|||..   ....|:.||
 Worm   817 DGDWPAIEKIACGQFHSAFICSDGSLWTFGWGVWGQLGHGGRNN--SNQLVPTRVNGLICKVTQI 879

  Fly  1282 SLGHAHTLVLCGAPNSHMEANHCGNELFVFGSNHFGQLGTGNSDHGDTK-----TNLPVRLEVGD 1341
            :.|.|||:||...           ..:.|.||..:||:|..:    |.|     |.||    :|.
 Worm   880 ACGRAHTVVLTDT-----------GRVLVCGSGSYGQMGVDD----DIKKVFAFTPLP----LGP 925

  Fly  1342 CSLRLIHTKFFTNLAVDEQDRLFTWGSSPQALRLANQIKRRANAKQKMEENQQRELLSKQLEATL 1406
            ..:|.|.|.::.::.:.|.:|:|.||.:||.|              ||.....:::.|.||:.|.
 Worm   926 LRVRDIATHYYHSICITEDNRVFEWGRNPQEL--------------KMRMFVMKKIRSAQLKNTE 976

  Fly  1407 LP-APIPSTSTLVEPTTSYAAVVAGSTPKSSVSDTKDCQDVQNEAAPSDATETIAPASAKAAPPP 1470
            .| :|.|||:              ||||:.::
 Worm   977 DPSSPSPSTN--------------GSTPRVNL--------------------------------- 994

  Fly  1471 VPVASPPVLVPEPDPTEHLTPHLVDTSEVAGRILQISSGLFHFCLISSSCTLYTWGKNLEHQLGT 1535
                :.|..:|..|.......|.:|     |.|:.::.||.|..||:|..|||||||.|::|||.
 Worm   995 ----NLPAEIPREDLGLREVKHFLD-----GNIVSVACGLSHSALITSEGTLYTWGKGLDYQLGH 1050

  Fly  1536 EDKDRR----AVLKPSPIDSIERPMYVDCGSDFTLVMTTDHVVRAFGGNSNGQCG---RDLGPSV 1593
            .:|:.|    .|.:|:....:.    |..|::.|:..|.|..|.|:|.|..||||   :..|.|.
 Worm  1051 GNKNERMEPHQVFEPNGAKWVN----VSLGNNHTIASTDDGSVFAWGKNDFGQCGVLTKKNGNSA 1111

  Fly  1594 ERMRQRVVCLPATKRLV-------RF-----ESQCVEVPVEINLPRPRIRLDQDPVRYLKVMPPY 1646
            :          .||:..       ||     |||.|:.|..|  |..|:|
 Worm  1112 D----------VTKKFFFQARDGRRFMPNVDESQFVQKPGLI--PDVRVR--------------- 1149

  Fly  1647 QPHFLQPANISFDQHCSVGTPNYKSSTEHAATGQDSDDMLSSLE----NLSQNDASFSYNAPVLG 1707
                    |::                |....|.|.::::..|:    |:.|..:...| :|:.|
 Worm  1150 --------NLN----------------EDGNEGVDKEEIVDRLKASDVNVVQAVSKHLY-SPIEG 1189

  Fly  1708 DAHSSLDMDYTPEEQSYVPLPEQAVGSGMPANAEQLLGRDDDDGSTYTQSTEGMGESSLQHLRHY 1772
            ..:.|:..|            |...|.....|.     .|.:||...|       .::|.||
 Worm  1190 KCNGSIIED------------EPRNGKIQKQNK-----YDGEDGPLCT-------TTALVHL--- 1227

  Fly  1773 IHYCLYAFHGLYNPDKIGECARPHRNEYRIRICMLNFRFVEAFRLCLQSCGSAQRTLKLFEYFSK 1837
                                                            ..|..:|.:::.|:.
 Worm  1228 ------------------------------------------------IAGDVKRAIRMIEWL-- 1242

  Fly  1838 DTGYVPLRRTDLKHLIYHLCLHFLERKFDMLECERFFMGDLDYYLLELAYVFYFNNNNSTLEQNL 1902
                                      |.|...||:..|     .|..|.:....|:.:....:.|
 Worm  1243 --------------------------KTDSSTCEKSLM-----VLSSLVWEVMANHEDVQSREAL 1276

  Fly  1903 NQKFKQLIAAADSNQAATSAGQELEQL----------------QDTDVIFDSFTVKFKTILCQRL 1951
            :..|:. :..:||.:    .|:::.||                .:...:.|.||...|.:.|..:
 Worm  1277 SAAFRH-VPMSDSMR----KGKQIAQLWPAVWNDERVQSSLSIDEKIAMLDGFTSASKPVSCPTI 1336

  Fly  1952 LSYS 1955
            .|.|
 Worm  1337 PSSS 1340

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ca	NP_733309.3	ATS1	1181..1587	CDD:444065	122/425 (29%)
glo-4	NP_505392.3	ATS1	773..1114	CDD:444065	127/449 (28%)