DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ca and W09G3.7

DIOPT Version :9

Sequence 1:	NP_001287593.1	Gene:	ca / 43518	FlyBaseID:	FBgn0000247	Length:	1961	Species:	Drosophila melanogaster
Sequence 2:	NP_001021671.2	Gene:	W09G3.7 / 173245	WormBaseID:	WBGene00012370	Length:	404	Species:	Caenorhabditis elegans

Alignment Length:	468	Identity:	93/468 - (19%)
Similarity:	158/468 - (33%)	Gaps:	135/468 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  1113 ESSRFKPISAG-------CAYCACVVDGTAYFWGSSGIPSY------YSAQKSTEPPEPAH-AVK 1163
            :::||...|||       ||...|.:..:    |:..||..      .:|.::..|...|: ..|
Worm     6 QTTRFLSNSAGKTRKNVDCAVYGCGLSAS----GALAIPKLVANSDDVTAGEARFPKRIAYFNTK 66

  Fly  1164 SLDLLSQLNLQVHAIKCGRQHTLILTNNGLYSLGNNNLCQLG-----IGRHMQMALQPMLVTALD 1223
            |:..:|.          |...:|..:.|.||..|.||..|:|     |.::....:....:. :.
Worm    67 SIKFISS----------GFGFSLFASKNRLYGAGINNRFQIGGQLTNINKYQDYYISAKKIN-IP 120

  Fly  1224 GMNITMLEAGQYHNAAVADGKLYMWGWGIYGQLGQ---------GSCENIATPQLVSFFKFKKIL 1279
            |..|..:.:|:.|:....:..::..|...:||.|:         ||.|:...|  :||...:.|:
Worm   121 GDEILEISSGRAHSLIRTNLGVFAIGDNNFGQCGRNPENMDYVVGSEESPLLP--LSFPTSEPII 183

  Fly  1280 QISLGHAHTLVLCGAPNSHMEANHCGNE----------LFVFGSNHFGQLGTGNSDHGDTKTNLP 1334
            .|                     ||..:          :|.||.|..||  .||..:|.......
Worm   184 SI---------------------HCSMDTSFVVDSSGAVFSFGLNEDGQ--CGNEAYGIQWEPAK 225

  Fly  1335 VRLEVGDCSLRLIHTKFFTNLAVDEQDRLFTWGSSPQALRLANQIKRRANAKQKMEENQQRELLS 1399
            ||.:|....::.:.....|.||..|...:|.||.:        :..:.|.|..:::.|..|.:
Worm   226 VRGDVEGSKIQKVSGSTDTLLACSENGEIFIWGQT--------EYGQAAGATDEIQLNTSRHV-- 280

  Fly  1400 KQLEATLLPAPIPSTSTLVEPTTSYAAVVAGSTPKSSVSDTKDCQDVQNEAAPSDATETIAPASA 1464
                                 ..|...::...:.:|||                         .|
Worm   281 ---------------------ANSLGPIICVDSTQSSV-------------------------VA 299

  Fly  1465 KAAPPPVPVASPPVLVPEPDPTEHLTPHLVDTSEVAGR-ILQISSGLFHFCLISSSCTLYTWGKN 1528
            :.:...|.|....||...|:.....||..:|.....|: :..:|:|......|:....|:.||:|
Worm   300 RNSRGNVFVWGVGVLGMGPEAESLKTPTQMDQPLFDGKMVTSVSAGNSCMSAINEDGRLFIWGEN 364

  Fly  1529 LEHQLGTEDKDRR 1541
            ....||...:.|:
Worm   365 RYSSLGLGHQKRQ 377

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ca	NP_001287593.1	ATS1	1158..1588	CDD:227511	80/410 (20%)
		RCC1_2	1175..1200	CDD:290274	6/24 (25%)
		RCC1	1193..1240	CDD:278826	12/51 (24%)
		RCC1	1242..1291	CDD:278826	12/57 (21%)
		RCC1_2	1503..1532	CDD:290274	7/28 (25%)
		RCC1	1522..1568	CDD:278826	7/20 (35%)
		RCC1_2	1558..1584	CDD:290274
W09G3.7	NP_001021671.2	ATS1	<108..347	CDD:227511	57/320 (18%)
		RCC1	142..195	CDD:278826	14/75 (19%)
		RCC1	198..239	CDD:278826	12/42 (29%)
		RCC1	355..402	CDD:278826	7/23 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010