DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ca and nek8

DIOPT Version :9

Sequence 1:	NP_001287593.1	Gene:	ca / 43518	FlyBaseID:	FBgn0000247	Length:	1961	Species:	Drosophila melanogaster
Sequence 2:	NP_620776.1	Gene:	nek8 / 171094	ZFINID:	ZDB-GENE-020509-1	Length:	697	Species:	Danio rerio

Alignment Length:	598	Identity:	119/598 - (19%)
Similarity:	191/598 - (31%)	Gaps:	189/598 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly  1031 VLQRLSKQLNP----FSPALRPIVSHNSDCAMSNDNNPQLFEFCKSLIETYLAVLIHMESQRVKY 1091
            ||:.:|....|    :||.||.::.:..:  :.....|||.|.....|.....:.::.:...||.
Zfish   212 VLKIMSGTFAPISDRYSPELRQLILNMLN--LDPSKRPQLNEIMAHAICIRPLLNLYTDIGNVKM 274

  Fly  1092 DSIVNALSNFRINYEDNQFA-IESSRFK---------------PISAGCAYCACVVDGTAYFWGS 1140
            ..|...|||.:......... |.|:|.:               |:.            :.|.||
Zfish   275 RRIEKPLSNVQAGPHGRPGGWITSTRTRGGLSSLTSSKMMHPLPLF------------SVYTWG- 326

  Fly  1141 SGIPSYYSAQKSTEPPEPAHAVKSLDLLSQLNLQVHAIKCGRQHTLILTNNGLY------SLGNN 1199
            |||.:            |..       |..||.:|..:..||...:.:|.:|..      |:|:.
Zfish   327 SGIST------------PLR-------LPMLNTEVIQVSLGRTQKMGVTKSGRLITWEAPSVGSG 372

  Fly  1200 NLCQLGIGRHMQMALQPMLVTALDGMNITMLEAGQYHNAAVAD-GKLYMWGWGIYGQLGQGSCEN 1263
            .....|....||.......:....|:.|..:..|......:.| |.:..:|.|..|.||.|:..:
Zfish   373 EPTLPGAVEQMQPQFISRFLEGQSGVTIKSVSCGDLFTTCLTDRGIIMTFGSGSNGCLGHGNFND 437

  Fly  1264 IATPQLVSFFKFKKILQISLGHAHTLVLCGAPNSHMEANHCGNELFVFGSNHFGQLG--TGNSDH 1326
            :..|         ||::..||:....|.|||  ||:.|.....|:|.:|....|:||  |.:|.:
Zfish   438 VTQP---------KIVEALLGYELVQVSCGA--SHVLAVTNEREVFSWGRGDNGRLGLATQDSHN 491

  Fly  1327 GDTKTNLPVRLEVG------DCSLRLIHTKFFTNLAVDEQDRLFTWGSSPQALRLANQIKRRANA 1385
            ...:.:||...|..      |||           :.:..|.::...|:        |:..:....
Zfish   492 CPQQVSLPADFEAQRVLCGVDCS-----------MIMSTQHQILACGN--------NRFNKLGLD 537

  Fly  1386 KQKMEENQQRELLSKQLEATLLPAPIPSTSTLVEPTTSYAAVVAGSTPKSSVSDTKDCQDVQNEA 1450
            |....|.                   ||:...||....:..|                     ::
Zfish   538 KVSGTEE-------------------PSSFCQVEEVHLFQLV---------------------QS 562

  Fly  1451 APSDATETIAPASAKAAPPPVPVASPPVLVPEPDPTEHLTPHLVDTSEVAGRILQISSGLFHFCL 1515
            ||.:                               ||              :|:.|..|..|...
Zfish   563 APLN-------------------------------TE--------------KIVYIDIGTAHSVA 582

  Fly  1516 ISSSCTLYTWGKNLEHQLGTEDKDRRAVLKPSPIDSIERPMYVDCGSDFTLVMTTDHVVRAFGGN 1580
            ::.....:|:|.|...|||.  ..||:...|..:..::......||..|||.:..:..|..:|..
Zfish   583 VTEKGQCFTFGSNQHGQLGC--SHRRSSRVPYQVSGLQGITMAACGDAFTLAIGAEGEVYTWGKG 645

  Fly  1581 SNGQCGR---DLG 1590
            :.|:.||   |.|
Zfish   646 ARGRLGRKEEDFG 658

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ca	NP_001287593.1	ATS1	1158..1588	CDD:227511	88/447 (20%)
		RCC1_2	1175..1200	CDD:290274	7/30 (23%)
		RCC1	1193..1240	CDD:278826	8/52 (15%)
		RCC1	1242..1291	CDD:278826	13/49 (27%)
		RCC1_2	1503..1532	CDD:290274	7/28 (25%)
		RCC1	1522..1568	CDD:278826	14/45 (31%)
		RCC1_2	1558..1584	CDD:290274	7/25 (28%)
nek8	NP_620776.1	STKc_Nek8	3..258	CDD:270859	12/47 (26%)
		S_TKc	4..255	CDD:214567	12/44 (27%)
		ATS1	309..662	CDD:227511	97/499 (19%)
		RCC1 1	417..468		19/61 (31%)
		RCC1 2	469..520		14/61 (23%)
		RCC1 3	521..586		17/157 (11%)
		RCC1 4	587..636		14/50 (28%)
		RCC1 5	637..689		7/22 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010