Protein Alignment ca and HERC2

DIOPT Version :10

• Sequence 1: NP_733309.3
• Gene: ca / 43518
• FlyBaseID: FBgn0000247
• Length: 1961
• Species: Drosophila melanogaster
• Sequence 2: XP_061516765.1
• Gene: HERC2 / 1280824
• VectorBaseID: AGAMI1_012955
• Length: 5199
• Species: Anopheles gambiae
• Alignment Length: 1781
• Identity: 337/1781 - (18%)
• Similarity: 561/1781 - (31%)
• Gaps: 704/1781 - (39%)

  Fly   373 SGPGAANSDPSTVSASAEAATADVPPPPAPPSYSEAVARQSGDQGGVRFQQQQLPAGSMDGILPA 437
            ||.||..:..:|.|.:|.||||  .||.|..:.:.|.|                       ..|.
Mosquito     6 SGSGAVGAAAATGSTAAPAATA--APPTATTTTTTAAA-----------------------AAPT 45

  Fly   438 TRARLASLKSLGSKKLQAIKMRLSDQRQKFDEFMPDSTMGSFAIMDSPSVTPEPLGTTSGSFY-- 500
            |..                                           |.|||| |.|...|..|
Mosquito    46 TAT-------------------------------------------SASVTP-PSGGGQGELYFR 66

  Fly   501 NIQNLRSTFLLSALHSNSHSLTVHSIDISLKPLFVYKIPKH---TQEILISSNILYGIHYVDLHC 562
            .:..|...::.:.:.|     .:.:.| .|..|:.:.|...   |:.:..:.|.|..:.|:
Mosquito    67 PLPYLSFKWIKADVGS-----ALRNAD-DLANLWNHLIQDEEVTTERVQTAVNGLGELVYL---- 121

  Fly   563 RSDSDHF--TAASLLD------------------------------DP---LVANTEKEN-RDAD 591
            |.|..::  ..|.|.|                              ||   ..|.:...| |.|.
Mosquito   122 RPDGRYYCGNVAILCDCCKGVCSAVSKCICPTCEELGVQEGAGGGGDPSSGAAAGSNGANGRKAQ 186

  Fly   592 IEKVDQSDVSAQKSDSTSATTTATSS---LDQ---SDMPST-----AINAV-----SVISSAMAS 640
            .:...||..:.|.:::.:|...:::|   ||.   |.:|.|     .|..:     .:...|..:
Mosquito   187 TQNHTQSSPADQPANAAAAAGDSSASSVLLDSWLWSPVPGTEDKKECIKKLIGEQREICLQAAGN 251

  Fly   641 LHTSDEDR---------FNNLAQLGLFRFENETVLHLYQMAQ--------YRNPSAEPETLTKEE 688
            ..:::..|         |..|.::|:.| |.|...|..::|.        .:|.|.:....|.::
Mosquito   252 CLSANRTRQLLFVYRRYFIALQEMGMHR-ETEEKQHATELATSECDAAKLSKNSSLDRTAGTAKD 315

  Fly   689 KAKA-FELKDIHT--PMDYIQFY--------ETADVSSEFSLRQMEIMQSEFPKIN-YDPSYVIT 741
            ..|| |.|..:.|  .:::...:        |..::.||.....:|.:|| .|:.: :|.|.:.|
Mosquito   316 SDKATFGLARVGTRAALNFSFAFLRRAWRSGEDVELCSELLSEALEALQS-LPEASLFDTSQMST 379

  Fly   742 NKNVYTIQLKKEPFELFLDAALQNEFNQCRDFCNTFDLSFEQCIEF-----AGDYLLRRKKITQA 801
                           |:::..                   |:.|:|     .||.:..|..:.:|
Mosquito   380 ---------------LWIEVV-------------------EKSIKFLRQVVLGDVMGGRCLVPKA 410

  Fly   802 LLTYNKARVKPIRTALKLAMYGHTYALMQLSAMALKSTYLLRSRYLGHPLLKGILGDITY----R 862
                      ....||.|        |::|.|.  |.|       ||.. |:|:...:|.    .
Mosquito   411 ----------DRHIALNL--------LLELGAQ--KGT-------LGGS-LEGVSLLLTLHEKDH 447

  Fly   863 HSEDVR--------VILPEKHEEEDVNS-GVFCS--DYHYGVDESISALQMSPSSQ-----FHLA 911
            .|:|.|        .::|..|..|.:.| |.|.:  .:|:|..||.......|.::     ..||
Mosquito   448 QSDDNRSPPQNSGAPLVPLLHRYEQIESFGSFATSDSFHFGPTESFLRFLALPDNETTCVDLKLA 512

  Fly   912 NLLLITLAEKAVNDKNYIPLWNFLVTNSKYHTNMTSIV-----LCQSGLFSSAIILAKIRGVCLD 971
            .:::|:..::..  |.::|..|.....:..:.|...|.     .|...|:......| ||..|.|
Mosquito   513 AVIIISHLDRLA--KPHLPAGNCSTKGASKYANAPKIFTLGWSACAPELYGFTATEA-IRTGCAD 574

  Fly   972 TFNALISVVAQEFGWYNELNVCLYNLSENIFLETITYLPHVSMDYFAFIQEKLHHIRPCVLQRLS 1036
             |:|:::.|.
Mosquito   575 -FDAMVTSVT------------------------------------------------------- 583

  Fly  1037 KQLNPFSPALRPIVSHNSDCAMSNDNNPQLFEFCKSLIETYLAVLIHMESQRVKYDSIVNALSNF 1101
                  :|.       :.|.||..                |....|.:...:|:  .||
Mosquito   584 ------APG-------SIDGAMPR----------------YSTATIDLLLDQVR--QIV------ 611

  Fly  1102 RINYEDNQFAIESSRFKPISAGCAYCA--CVVDGTAYFWGSSGIPSYYS-AQKSTEPPEPAHAVK 1163
                                     ||  ||     |....||...|.| |...||...||. ||
Mosquito   612 -------------------------CAENCV-----YILTDSGTVLYLSHAISMTEDNYPAQ-VK 645

  Fly  1164 SLD-LLSQLNLQVHAIKCGRQHTLILTNNG-LYSLGNNNLCQLGIGRHMQMALQPMLVTALDGMN 1226
            .|: .:.||     |..|..:|.|.|.::| :||.|:.:..:||.|......| |..:|||....
Mosquito   646 GLECTIVQL-----AAHCEGRHVLALASSGDVYSWGSGDGGRLGHGDTSAKEL-PTRITALADRQ 704

  Fly  1227 ITMLEAGQYHNAAV-ADGKLYMWGWGIYGQLGQGSCENIATPQLVSFFKFKKILQISLGHAHTLV 1290
            :|.:..|..::||: |.|:||.||.|.||:||.|:.|:...|.||:..|..:::.::||
Mosquito   705 VTGVFCGSSYSAAITASGELYTWGRGTYGRLGHGNSEDKYVPTLVTALKAHRVVHVALG------ 763

  Fly  1291 LCGAPNSHMEANHCGNE---LFVFGSNHFGQLGTGNSDHGDTKTNLPVRLEV--GDCSLRLIHTK 1350
             ||..:|     .|..|   .|.:|...||:||    :.....|::||::::  ..|.:::....
Mosquito   764 -CGDAHS-----LCVTEAGLAFAWGDGDFGKLG----NESCVGTSVPVQVDLPQASCVVKVFSGS 818

  Fly  1351 FFTNLAVDEQDRLFTWGSSPQALRLANQIKRRANAKQKMEENQQRELLSKQLEATLLPAPIPSTS 1415
            .| ::|:..:..::|||.. ...||.:
Mosquito   819 QF-SVALTREGTVYTWGKG-HGGRLGH-------------------------------------- 843

  Fly  1416 TLVEPTTSYAAVVAGSTPKSSVSDTKDCQDVQNEAAPSDATETIAPASAKAAPPPVPVASPPVLV 1480
                          |::..|.|
Mosquito   844 --------------GNSEHSPV------------------------------------------- 851

  Fly  1481 PEPDPTEHLTPHLVDTSEVAGRILQISSGLFHFCLISSSCTLYTWGKNLEHQLGTEDKDRRAVLK 1545
                      |.:|...| ..:|:.::.||.|...:::|..||.||:|...|:..|...|
Mosquito   852 ----------PKMVQALE-GKKIVDLAVGLAHCLALTASGELYGWGRNDFQQICPECVTR----- 900

  Fly  1546 PSPIDSIERPMYVDCGSDFTLVMTTDHVVRAFG-------------GNSNGQCGR-----DLGPS 1592
             .||  |..|           ::||...:|..|             .:|:|...:     ||...
Mosquito   901 -DPI--ITAP-----------ILTTPPTLRVAGMAAGVAQSLFWCHSSSHGIPAKIPFVVDLSEH 951

  Fly  1593 VERMRQRVVCL-------PATKRLVRFESQCVEVPVEINLPR------------PR--------- 1629
            ..|:..:::|:       .|::.....|::|:.| ..:||.|            ||
Mosquito   952 TFRLLDQLLCMVSVTSSTDASRHPPSQEAECIAV-ATLNLLRLQLHAMIVNNVHPRQVGLVEGSR 1015

  Fly  1630 ---------IRLDQDPVRYLKVMPPYQPHFLQPANISFDQHCSVGTPNYKSSTEHAAT------- 1678
                     :.|...|| .||.|.       :.|..:.....|:..|   :::|.|.|
Mosquito  1016 LLASLKTRILSLAGGPV-VLKTMQ-------EAAQWTLQVGWSIILP---TASERAQTLTSLLPA 1069

  Fly  1679 GQDSDDMLSSLENLSQNDASFSYNAPVL-------GDAHSSLD--MDYTPEEQSYVPLPEQAVGS 1734
            |.|..   :::.:.:|..|...:...:|       |...::|:  :::...:..:........||
Mosquito  1070 GHDGG---ATIGSAAQTSAGHRFMTDLLVGSLMAEGGLQTALNQAINHHQHQNPFQAQEPHGAGS 1131

  Fly  1735 GMPANAEQLLGRDDDDGSTYTQSTEG---MG---------------ESSLQHLRHYIHYCLYAFH 1781
            |...:...||.:...:.|:.||:..|   :|               ..||..|..:....|...:
Mosquito  1132 GTHLSLLHLLKQLLRNNSSLTQARLGQLMLGPYLKPDDGFSAPEPTSPSLDLLHKFQRLLLSHLY 1196

  Fly  1782 GLYNPDKIGECARPHRNEYRIRICMLNFRFVEAFRLCLQSCGSAQRTL-KLFEYF--SKDTGYVP 1843
            .....|..|..|             |.:.:::      |..|....|| |.:|..  .|| |...
Mosquito  1197 ASKADDLSGAEA-------------LLYTYIQ------QLVGPCVNTLAKAYETILQGKD-GVTE 1241

  Fly  1844 LRRTDLKH-LIYHLCLHFLERKFDMLECERFFMGDLDYYLLELAYVFYFNNNNSTLEQNLNQKFK 1907
            :.|.|:.. |:|.|.:..:..:.|    :.|.:.:.|:                      |:...
Mosquito  1242 ILRNDISDALLYELLIGLVVIQQD----KPFLLANFDW----------------------NRHLI 1280

  Fly  1908 QLIAAADSNQAATSAGQELEQLQDTD 1933
            .|:.|.|.....|..|    :|||||
Mosquito  1281 PLLNALDGFNRLTQEG----ELQDTD 1302

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ca	NP_733309.3	ATS1	1181..1587	CDD:444065	89/425 (21%)
HERC2	XP_061516765.1	None