DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ca and RCC1

DIOPT Version :9

Sequence 1:	NP_001287593.1	Gene:	ca / 43518	FlyBaseID:	FBgn0000247	Length:	1961	Species:	Drosophila melanogaster
Sequence 2:	NP_001041659.1	Gene:	RCC1 / 1104	HGNCID:	1913	Length:	452	Species:	Homo sapiens

Alignment Length:	333	Identity:	78/333 - (23%)
Similarity:	127/333 - (38%)	Gaps:	79/333 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly  1111 AIESSRFKP-----------ISAGCAYCACVV-DGTAYFWGS----SGIPSYYSAQKSTEPPEPA 1159
            ::|.|...|           :|||.::.|.:. ||..:.|||    :|:.......|.:..|
Human   135 SVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVP--- 196

  Fly  1160 HAVKSLDLLSQLNLQVHAIKCGRQHTLILTNNG-LYSLGNNNLCQLG------IGRHMQMALQPM 1217
                   :..||::.|..:..|..|.::||.:| ||:||.....|||      ..|..:..|:.:
Human   197 -------VQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERL 254

  Fly  1218 LVTALDGMNITMLEA--------------GQYHNAAVA-DGKLYMWGWGIYGQLGQGSCENIATP 1267
            ||.     ...||::              |.|...|:: :|.:|.:|...|.|||....|:...|
Human   255 LVP-----KCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIP 314

  Fly  1268 QLVSFFK--FKKILQISLGHAHTLVLCGAPNSHMEANHCGNELFVFGSNHFGQLGTGNSDHGDTK 1330
            |.::.||  .|..:..|.|..||:.:    :|..:|       :..|...:|:||.|......:.
Human   315 QNLTSFKNSTKSWVGFSGGQHHTVCM----DSEGKA-------YSLGRAEYGRLGLGEGAEEKSI 368

  Fly  1331 TNLPVRLEVGDCSLRLIHTKFFTNLAVDEQDRLFTWGSSPQALRLANQIKRRANAKQKMEENQQR 1395
            ..|..||.    ::..:........||.:..|:|.||..         ...:....|..:.....
Human   369 PTLISRLP----AVSSVACGASVGYAVTKDGRVFAWGMG---------TNYQLGTGQDEDAWSPV 420

  Fly  1396 ELLSKQLE 1403
            |::.||||
Human   421 EMMGKQLE 428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ca	NP_001287593.1	ATS1	1158..1588	CDD:227511	63/270 (23%)
		RCC1_2	1175..1200	CDD:290274	10/25 (40%)
		RCC1	1193..1240	CDD:278826	15/66 (23%)
		RCC1	1242..1291	CDD:278826	17/50 (34%)
		RCC1_2	1503..1532	CDD:290274
		RCC1	1522..1568	CDD:278826
		RCC1_2	1558..1584	CDD:290274
RCC1	NP_001041659.1	RCC1	66..113	CDD:278826
		RCC1	116..165	CDD:278826	7/29 (24%)
		RCC1	168..218	CDD:278826	13/59 (22%)
		RCC1	221..286	CDD:278826	16/69 (23%)
		RCC1	289..340	CDD:278826	17/50 (34%)
		RCC1	343..386	CDD:278826	9/53 (17%)
		RCC1	394..445	CDD:278826	10/44 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820