DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ca and RCBTB2

DIOPT Version :9

Sequence 1:	NP_001287593.1	Gene:	ca / 43518	FlyBaseID:	FBgn0000247	Length:	1961	Species:	Drosophila melanogaster
Sequence 2:	XP_016875858.1	Gene:	RCBTB2 / 1102	HGNCID:	1914	Length:	561	Species:	Homo sapiens

Alignment Length:	363	Identity:	87/363 - (23%)
Similarity:	146/363 - (40%)	Gaps:	76/363 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly  1051 SHNSDCAMSNDNNPQ---------------LFEFCKSLIETYLAVLIHMESQRVKYDSIVNALSN 1100
            ||:..|:::|....|               :|..|.   |..|.::    .|...:.|..|.:..
Human    13 SHSFTCSLTNTKPVQATLSSLKMLDVGKWPIFSLCS---EEELQLI----RQACVFGSAGNEVLY 70

  Fly  1101 FRINYE---------------DNQFAIESSRFKPISAGCAYC----------ACVVDGTAYFWGS 1140
            ..:|.|               |.|..||..|...::.....|          ....:|..:.||.
Human    71 TTVNDEIFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIACLSYGSGPHIVLATTEGEVFTWGH 135

  Fly  1141 SGIPSYYSAQKSTEPPEPAHAVKSLDLLSQLNLQVHAIKCGRQHTLILTNNG-LYSLGNNNLCQL 1204
            :.. |......:.....|.|...:|.     |.||..:.||..|:|:||::| :::.|.||..|:
Human   136 NAY-SQLGNGTTNHGLVPCHISTNLS-----NKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQV 194

  Fly  1205 GIGRHMQMALQPMLVTALDGMNITMLEAGQYHNAAVAD-GKLYMWGWGIYGQLGQGSCENIATPQ 1268
            |.|..:...:...:...|....:..:..||....||.| |::|:||:...||||.|:..|..||.
Human   195 GSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPTPC 259

  Fly  1269 LVSFFKFKKILQISLGHAHTLVLCGAPNSHMEANHCGNELFVFGSNHFGQLGTGNSDHGDTKTNL 1333
            .|:..:..::.:::.|:||||||...           .:::.:|:|.:|||||||..:....|.:
Human   260 RVAALQGIRVQRVACGYAHTLVLTDE-----------GQVYAWGANSYGQLGTGNKSNQSYPTPV 313

  Fly  1334 PVR----LEVGDCSLRLIHTKFFTNLAVDEQDRLFTWG 1367
            .|.    :|:..|     |:. .|:.|..:...::.||
Human   314 TVEKDRIIEIAAC-----HST-HTSAAKTQGGHVYMWG 345

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ca	NP_001287593.1	ATS1	1158..1588	CDD:227511	63/216 (29%)
		RCC1_2	1175..1200	CDD:290274	9/25 (36%)
		RCC1	1193..1240	CDD:278826	9/46 (20%)
		RCC1	1242..1291	CDD:278826	19/49 (39%)
		RCC1_2	1503..1532	CDD:290274
		RCC1	1522..1568	CDD:278826
		RCC1_2	1558..1584	CDD:290274
RCBTB2	XP_016875858.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143333
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	4	3.800