DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ca and herc1

DIOPT Version :9

Sequence 1:	NP_001287593.1	Gene:	ca / 43518	FlyBaseID:	FBgn0000247	Length:	1961	Species:	Drosophila melanogaster
Sequence 2:	XP_017947876.1	Gene:	herc1 / 100493988	XenbaseID:	XB-GENE-1002062	Length:	4854	Species:	Xenopus tropicalis

Alignment Length:	940	Identity:	191/940 - (20%)
Similarity:	319/940 - (33%)	Gaps:	308/940 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly  1083 HMESQRVKYDSIVNALSNFRINYEDNQFAIESSRFKPISAGCAYCACVV-DGTAYFWG------- 1139
            |..|...||..::             |..::......:|||..:.|.|. ||..|.||
Frog   492 HGNSSTQKYPKLI-------------QGTLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRL 543

  Fly  1140 ------SSGIPSYYSAQKSTEPPEPAHAVKSLDLLSQLNLQVHAIKCGRQHTLILTNNG--LYSL 1196
                  |..||:               .||.:.       .|..:.||..||:.|:.:|  ::|.
Frog   544 GHGDSNSRNIPT---------------LVKDIS-------NVGEVSCGSSHTIALSKDGRTVWSF 586

  Fly  1197 GNNNLCQLGIGRHMQMALQPMLVTALDGMNITMLEAGQYHNAAV-ADGKLYMWGWGIYGQLGQGS 1260
            |..:..:||.| ......:|.:|.||.||....:.||...:.|: :.|::|.||.|  ..||.||
Frog   587 GGGDNGKLGHG-DTNRVYKPKVVEALQGMFTRKVCAGSQSSLALTSTGQVYAWGCG--ACLGCGS 648

  Fly  1261 CENIA-TPQLVSFFKFKKILQISLGHAHTLVLCGAPNSHMEANHCGNELFVFGSNHFGQLGTGNS 1324
            .|..| .|:|:......:|:.||:|.:|.|.|     ||      .||::.:|:|..||.|.|||
Frog   649 SEATALRPKLIEELAATRIVDISIGDSHCLAL-----SH------DNEVYAWGNNSMGQCGQGNS 702

  Fly  1325 DHGDTKTNLPVRLE---VGDCSLRLIHTKFFTNLAVDEQDRLFTWG------------------- 1367
            ....||......|:   :...|....|:..:|.|..|.|  :..|.
Frog   703 TGPITKPKKVSGLDGVAIQQISAGTSHSLAWTALPRDRQ--VVAWHRPYCVDLEESTFFHLRSFL 765

  Fly  1368 ---------------------------------SSPQALRLANQIK-----RRANAKQKM----- 1389
                                             |:..||.||..:.     |:|...:.:
Frog   766 ERYCEKINSEIPPPPFPSSRDHHGFLKLCLKMLSNHLALALAGGVATSILGRQAGPLRNLLFRLM 830

  Fly  1390 -----EENQQRELLSKQLEATLLPAPIPST-----STLVEPTTSYAAVVAGSTPK-----SSVSD 1439
                 :|.|:..:.:..:.||:|..|:...     |.|.:....:.::..|...:     :|:.|
Frog   831 DASVPDEIQEVVIETLSVGATMLLPPLRERMELLHSLLPQGPDRWESLSKGQRMQLDIILTSLQD 895

  Fly  1440 TKDCQDVQNEAAPSDATETIAPASAKAAPPPVPVASPPVLVPE-PDPTEHLTPHLVDT------- 1496
            ......:...:.|||:::..:          :|:.|.|....: ..|..||...|:.|
Frog   896 HTHVASLLGYSTPSDSSDVTS----------LPMTSDPSYSSQGSHPDTHLAEILMKTLLRNLGF 950

  Fly  1497 -SEVAGRILQISSGLFHFCLISSSCTLYTWGKNLEHQLGTEDKDRRAVLKPSPIDSIERPMYVDC 1560
             ::.|...|:.:|..|   ::.:|.:..:...:| |:|               :.|:::.:...|
Frog   951 YTDQAFGELEKNSDKF---IVGASSSENSQPAHL-HEL---------------LCSLQKQLLAYC 996

  Fly  1561 GSDFT-------------LVMTTDHVVRAFGGNS--------NGQCGRDLGPSVERMRQRVVCLP 1604
            .::..             |.:...|....:..::        ||..|       |::|..:....
Frog   997 HTNHISENSSSVALLHKHLQLLLPHATDIYSRSATLLEESPWNGSVG-------EKLRDVIYVSA 1054

  Fly  1605 ATKRLVRFESQCVEVPVEINLPRPRIRLDQDPV--RYLKVMP------------PYQ--PHFLQP 1653
            |...|.:..:..:.:|..:..|.....||..|.  |..:::|            |..  |..:.|
Frog  1055 AGSMLCQLVNALLLLPASVARPLLSYLLDLLPPLDRLNRLLPAAALLEDQELQWPLHGGPEHIDP 1119

  Fly  1654 ANISF-----------DQHCSV-------------GTP--------NYKSSTEHAATGQDS---- 1682
            ..:|.           |...:|             |:|        ||...|.....|.|.
Frog  1120 GGVSLPAPAQSWVWLVDLERTVALLIGRCLGGMLQGSPASPEEQDTNYWLKTPLFGNGIDMEVPQ 1184

  Fly  1683 -DDMLSSLENLSQNDASFSYNAPVLGDAHSSLDMDYTPEEQSYVPLPEQAVGSGM-PANAEQLLG 1745
             |..:|:|     .:.|.|.|     :...:.|....||....|.|   ||||.. ||....:..
Frog  1185 LDKCMSAL-----LEVSLSGN-----EEQKTFDYKLRPEVSLLVDL---AVGSTKEPAQNLWISM 1236

  Fly  1746 RD-----DDDGSTYTQSTEGMGESSLQHLRHYIHYCLYAFHGL---------YNPDKIGECARPH 1796
            :|     |.|.:|.:      .||.|..:..::...|....||         |.|:|  ..|..:
Frog  1237 QDYAISKDWDSATVS------NESLLDTVSRFVLAALLKHTGLLSQATVDSRYQPEK--SLAEVY 1293

  Fly  1797 RNEYRIRICMLNFRFVEAFRLCLQSCGSAQ 1826
            ||.|::|..:|..:.:|    .:|:|.|::
Frog  1294 RNVYKVRSRLLACKNME----LIQTCSSSR 1319

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ca	NP_001287593.1	ATS1	1158..1588	CDD:227511	109/543 (20%)
		RCC1_2	1175..1200	CDD:290274	9/26 (35%)
		RCC1	1193..1240	CDD:278826	13/46 (28%)
		RCC1	1242..1291	CDD:278826	19/49 (39%)
		RCC1_2	1503..1532	CDD:290274	5/28 (18%)
		RCC1	1522..1568	CDD:278826	6/58 (10%)
		RCC1_2	1558..1584	CDD:290274	4/46 (9%)
herc1	XP_017947876.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920