DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ca and herc2

DIOPT Version :9

Sequence 1:NP_001287593.1 Gene:ca / 43518 FlyBaseID:FBgn0000247 Length:1961 Species:Drosophila melanogaster
Sequence 2:XP_012813154.2 Gene:herc2 / 100487407 XenbaseID:XB-GENE-1012659 Length:4848 Species:Xenopus tropicalis


Alignment Length:2179 Identity:408/2179 - (18%)
Similarity:708/2179 - (32%) Gaps:726/2179 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 GMFELRPLITNISCKLSAVTAGLDEKRQFLCLVSEENEILLRYISAASGQEVV--KMISW----F 69
            |...|.|..||||..|:.....:|       |:...|.:||         ||.  |:.:|    .
 Frog  1704 GWQRLAPEGTNISEPLTDCLKDVD-------LIPPFNRMLL---------EVTFGKLYAWAVQNI 1752

  Fly    70 RNRVIH-DVCFDPAGVWLLVL-CFDNTLHIVPALALVDKA-------------HGLSACSLYSTT 119
            ||.::. ..||...|:..:.| ...|.....|:|..:.:|             ||..:.:|...:
 Frog  1753 RNTLMDASSCFKEMGIQPVPLQTITNENPSGPSLGTIPQARFMLVMVNMLTCQHGAKSLNLLLNS 1817

  Fly   120 ---QVTSYIIPFVGPHECPNSKKCPN------HSTGLEESTAE--PMDQLAENLEQARLQE---- 169
               .:|..|:..:|| .|.||:...:      .:|.||||..|  |:...|...|.|.:.:    
 Frog  1818 GMLALTQTILRLIGP-SCENSEDDSSVCVMGASATVLEESRKETTPVQLPASGPELAAMMKIGTR 1881

  Fly   170 ---------GEEEEP---LGH---DLPEHMLVR--------NS---GTE-----------DAVQP 197
                     |:::.|   ||.   :|.|...:|        ||   |.|           .|.|.
 Frog  1882 VMRGVDWKWGDQDGPPPGLGRVIGELGEDGWIRVQWDTGSTNSYRMGKEGKYDLKLTEPPPATQA 1946

  Fly   198 LPQQQQTIDTTGNSQV--------------------------MAASFMASKT----CPYPLSVV- 231
            :.:...|.|.:...|:                          :.|..|.|:|    |.....:| 
 Frog  1947 MAEDSDTEDDSEGEQIDKNLHPTSLMLMSTVNLLQALCLSAGVNAEVMQSETTRTLCGLLRMLVE 2011

  Fly   232 ---WWKTNSGQNRAIIGYSDGSICFVGLSPN---CPMIASTAIENGSVMRLVICKDKAYDGVMLL 290
               ..||::..|:.:......|.|.:|...:   .|.:.||.    |:.:.:....|..:|....
 Frog  2012 SGTMDKTSTQSNKLVYKEQHKSWCTLGFIRSIAIMPQMCSTL----SMPQWISLLMKIVEGPESF 2072

  Fly   291 ITSSLKQQYKLLLEQKAIKYVYPGDSSPTTREGAWQIVMSVQDKHQSAATGARQSNSSDPASDSS 355
            ..:||::|   :|..:.::.|.|          :|       ||::.:.             |..
 Frog  2073 SAASLQRQ---ILAVRLLQAVLP----------SW-------DKNERSC-------------DMK 2104

  Fly   356 QLEEDVFAPPSSDDVVCSGPGAANSDPSTVSASAEAATADVPPPPAPPSYSEAVARQSGDQGGVR 420
            .|.|.:|                    |.:.:.....::|:|           :.|:|     ..
 Frog  2105 TLVEKLF--------------------SFLGSLLSTCSSDIP-----------LLRES-----TL 2133

  Fly   421 FQQQQLPAGSMDGILPATRAR--LASLKSLGSKKL------QAIKMRLSD-----QRQKFD---- 468
            .:::..|..|:.....:|.|.  :|.|::|.|...      :.|..:|:.     :.::||    
 Frog  2134 RRRKARPQASLTATHSSTLAEEIVALLRTLHSLNQWNGLINKYINSQLNSVTNIFEGKRFDMTVL 2198

  Fly   469 -EFMPDS----------------------TMGSFAIMDS------PSVTPEPLGTTSGSFYNIQN 504
             ::.|||                      .:|...:.|.      ..:||:  |..:..|::::.
 Frog  2199 EDYFPDSEGPEVGSLMAVLAVIGGIDSRLRLGGQVVQDEFGEGTVTRITPK--GKITVQFHDVRT 2261

  Fly   505 LRSTFLLSALHS------NSHSL----TVHSIDISLKPLFVYKIPKHTQEILISSNILYGIHYVD 559
            .| ...|:.||.      |.::|    ::.|:...|..|...|:.||..:..:...:...:....
 Frog  2262 SR-ICPLNQLHPMPVVPFNVNNLPFTDSMLSVWAQLVNLAGCKLEKHRLKKSMRQGLTDQVDLDR 2325

  Fly   560 LHCR--------------SDSDHFTAASLLDDPLVAN----TEKENRDADIEKVDQSDVSAQ--- 603
            |.|:              |..|..  ..:|..|.|..    ...|...|..|.||.|....|   
 Frog  2326 LRCQQLKLYILKAGRALLSHQDRL--RQILSQPSVQEPGLIASDEGATASPEMVDMSPEGPQPPM 2388

  Fly   604 ---KSDSTSAT--TTATSSLDQSDMPSTAINAVSVISSAMASLHTSDEDRFNNLAQLGLFRFENE 663
               :...|:||  :...:..|:.::.:.|:.....:  |:.|.|.| ...|.::..      .:|
 Frog  2389 ILLQQLLTAATQPSPVKAIFDKQELEAAALAVCQFL--AVESTHPS-TPLFEDICS------SSE 2444

  Fly   664 -----TVLHL--YQMAQYRNPSAEPETLTKEEKAKAFELKDIH---------------TP----- 701
                 |:.|:  .::.:.:.....|..:..:.....|:.|:|.               :|     
 Frog  2445 ASSPVTMQHIRPAKVKKRKQSPIPPVPIVVQLMEMGFQRKNIEFALKSLSGASGTASSSPGVEAL 2509

  Fly   702 ----MDY--IQFYETADV------SSEFSLRQMEIMQSEFPKINYDPSYVITNKNVYTIQ---LK 751
                :|:  ||..|.:|.      |.|..:.::|..::.:|..|   ..|:|....|..:   |.
 Frog  2510 VGWLLDHPDIQIAELSDAETASEDSDEEIVEEVEETEASYPMAN---GAVVTESQTYKKRADFLS 2571

  Fly   752 KEPFELFLDAALQ-NEFNQCRDFCNTFDLSFE-------------------QC--IEFAGDYLLR 794
            .:.:.:::...:| ....:|   |.|::...|                   ||  .|..|.|.:|
 Frog  2572 NDDYAVYVRENVQVGMMVRC---CRTYEEVCEGDVGKVIKLDRDGLYDLNVQCDWQEKGGTYWVR 2633

  Fly   795 RKKITQALLTY------------NKARVKPIRTALKLAMYGHTYALMQLSAMALKSTYLLRSRYL 847
              .|...||.:            :|.|||...|..|...                          
 Frog  2634 --YIHVELLGFPPQSSPSHIKIGDKVRVKASVTTPKYKW-------------------------- 2670

  Fly   848 GHPLLKGILGDITYR----------HSEDVRVILPEK-------HEEE---DVNSGVFCSDYHYG 892
                     |.:|:|          :.:||.|..|::       .|.|   .:::||.|      
 Frog  2671 ---------GSVTHRSVGVVKAFSANGKDVIVDFPQQSHWTGLLSEMELVPSIHAGVTC------ 2720

  Fly   893 VDESISALQMSP--SSQFHLANLLLITLAEKAVNDKNYIPLWNFLVT---NSKYHTNMT------ 946
                 ...||.|  .|:|..          :..:|      ::|..|   |.|::...|      
 Frog  2721 -----DGCQMFPIHGSRFKC----------RVCDD------FDFCDTCFKNRKHNARHTFGRINE 2764

  Fly   947 ---SIVLC----------QSGLFSSAIILAKIRGVCLDTFNALISVVAQEFGWYNELNVC--LYN 996
               |.|.|          .||.          ||:.||.::.::..:...    :.:|..  |.:
 Frog  2765 PGQSPVFCGRSGKQLKQRHSGQ----------RGMLLDDWSRIVKSLTVS----SSVNQASRLID 2815

  Fly   997 LSENIFLETITYLPH-VSMDYFAFIQEKLHHIRPCVLQRLSKQLNP----FSPALRPIVSHNSDC 1056
            .|:..:..:.:...| :.::.|..:          .:.||...::|    :.|:|..:...||  
 Frog  2816 GSDQCWQSSGSQGKHWIRLEIFPDV----------FVHRLVMTVDPADSSYMPSLVVVSGGNS-- 2868

  Fly  1057 AMSN------------DNNPQLFEFCKSLIETYLAVLIHMESQRVKYDSI------VNALSNFRI 1103
             ::|            |.|..|...|.. ...|:.:.|    ::.:...|      :|.:...|.
 Frog  2869 -LNNLIELKTININPTDLNVVLLTDCTE-YHRYIEIAI----KQCRSSGIDCKIHELNLVGQIRA 2927

  Fly  1104 ---------------NYEDNQFAIESSRFKPISAGCAYCACVVDGTAYFWGSSGIPSYYSAQKST 1153
                           :.||:..|...|..:..:||....| .:....:.||.:. .......|.:
 Frog  2928 EDEDMATVPFLASDNDEEDDDKASTGSFVRKKTAGLESTA-TIRTKVFVWGLND-KDQLGGLKGS 2990

  Fly  1154 EPPEPAHAVKSLDLLSQLNLQVHAIKCGRQHTLILTNNG-LYSLGNNNLCQLGIGRHMQMALQPM 1217
            :...|:.:    :.||.||  |..:..|.:....:|..| :|:.|.....:||:|........|.
 Frog  2991 KIKVPSFS----ETLSALN--VVQVAGGSKSLFAVTAEGKVYACGEATNGRLGLGISSGTVPIPR 3049

  Fly  1218 LVTALDG---MNITMLEAGQYHNAAVADGKLYMWGWGIYGQLGQGSCENIATPQLVSFFKFKKIL 1279
            .:|||..   ..:.:...|::..|...|||::.||.|..|:||..|..|...|:|:...|.|:|.
 Frog  3050 QITALSNYVVKKVAVHSGGRHATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIR 3114

  Fly  1280 QISLGHAHTLVLCGAPNSHMEANHCGNELFVFGSNHFGQLGTGNSDHGDTKTNLP---VRLEVGD 1341
            .|:.|.:|:..:..:           .||:.:|...:|:||     |||..|.|.   |::.:|.
 Frog  3115 DIACGSSHSAAITSS-----------GELYTWGLGEYGRLG-----HGDNTTQLKPKMVKVLLGH 3163

  Fly  1342 ------CSLRLIHTKFFTNLAVDEQDRLFTWGSSPQALRLANQIKRRANAKQKMEENQQRELLSK 1400
                  |..|...|     ||:.::..:|:||..... :|........|..|.:|....:.:.  
 Frog  3164 RVIQVACGSRDAQT-----LALTDEGLVFSWGDGDFG-KLGRGGSEGCNIPQNIERLNGQAVC-- 3220

  Fly  1401 QLEATLLPAPIPSTSTLVEPTTSYAAVVAGSTPKSSVSDTKDCQDVQNEAAPSDATETIAPASAK 1465
            |:|.                    .|..:.:..||.|..|....|.......:|           
 Frog  3221 QIEC--------------------GAQFSLALTKSGVVWTWGKGDYFRLGHGTD----------- 3254

  Fly  1466 AAPPPVPVASPPVLVPEPDPTEHLTPHLVDTSEVAGRILQISSGLFHFCLISSSCTLYTWGKNLE 1530
                        |.|.:|...|.|.         ..:|:.::.|..|...::.:..:|.||.|..
 Frog  3255 ------------VHVRKPQVVEGLR---------GKKIVHVAVGALHCLAVTDAGQVYAWGDNDH 3298

  Fly  1531 HQL--GTEDKDRRAVLKPSPIDSIE--RPMYVDCGSDFTLVMTTDHVVR-------AFGGNSNGQ 1584
            .|.  ||...:|    ||:.:..:|  :...|.|||..::..||..|..       .|      |
 Frog  3299 GQQGNGTTTVNR----KPTLVHGLEGQKITRVACGSSHSVAWTTVDVATPSVHEPVLF------Q 3353

  Fly  1585 CGRD-LGPSVERMRQRVVCLPATKRLVRFESQCVEVPVEINLPRPRIRLD-----QDPVRYLKVM 1643
            ..|| ||.|...:.......|::...:...|..  .|...:|.:..:.:|     |..:.:  ::
 Frog  3354 TARDALGASYLGVPSDSESSPSSSNKISGVSSL--KPNRPSLAKILLSIDGSLAKQQALSH--IL 3414

  Fly  1644 PPYQPHF--------LQPANISFDQHC---SVGTPNYKSSTEHAATGQD---SDDMLSSLENLSQ 1694
            ...|..:        |.||::.....|   |...|:..|.|.....|.|   :.|:...|.....
 Frog  3415 TALQIMYARDAVVGALMPASMIAPMECPSLSTAPPSDMSGTSSPINGDDIMLAMDLEDRLSPSPW 3479

  Fly  1695 NDASFSYNAPVLGDAHSSLDMDYTPEEQSYVPLPEQAVGSGMPANAEQLLGRDDDDGS------T 1753
            .|..        |:.:||.|          ...|.....|...|::...:...||.|:      |
 Frog  3480 QDRK--------GEVNSSED----------AVTPSAVTPSASAASSRPFIPVTDDPGAASIIAET 3526

  Fly  1754 YTQSTEGMGESSLQHLRHYIHYCLYAFHGLYNPD 1787
            .|::.|.:  .|...:......||..|..|..||
 Frog  3527 MTKTKEDV--ESQNKVTGPEPQCLDEFTSLLVPD 3558

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
caNP_001287593.1 ATS1 1158..1588 CDD:227511 101/453 (22%)
RCC1_2 1175..1200 CDD:290274 6/25 (24%)
RCC1 1193..1240 CDD:278826 11/49 (22%)
RCC1 1242..1291 CDD:278826 19/48 (40%)
RCC1_2 1503..1532 CDD:290274 7/28 (25%)
RCC1 1522..1568 CDD:278826 15/49 (31%)
RCC1_2 1558..1584 CDD:290274 8/32 (25%)
herc2XP_012813154.2 ATS1 <501..794 CDD:227511
Cyt-b5 1219..1291 CDD:395121
MIB_HERC2 1879..1939 CDD:399589 11/59 (19%)
UBA_HERC2 2471..2518 CDD:270585 5/46 (11%)
Cul7 2566..2643 CDD:402903 15/81 (19%)
SH3_15 2651..2708 CDD:408152 13/91 (14%)
ZZ_HERC2 2718..2762 CDD:239084 13/70 (19%)
APC10-HERC2 2777..2922 CDD:176485 27/176 (15%)
ATS1 2968..3334 CDD:227511 99/452 (22%)
ATS1 4037..4342 CDD:227511
HECTc 4435..4806 CDD:238033
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1062377at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.920

Return to query results.
Submit another query.