Protein Alignment ca and herc2

DIOPT Version :10

• Sequence 1: NP_733309.3
• Gene: ca / 43518
• FlyBaseID: FBgn0000247
• Length: 1961
• Species: Drosophila melanogaster
• Sequence 2: XP_012813154.2
• Gene: herc2 / 100487407
• XenbaseID: XB-GENE-1012659
• Length: 4848
• Species: Xenopus tropicalis
• Alignment Length: 2179
• Identity: 408/2179 - (18%)
• Similarity: 708/2179 - (32%)
• Gaps: 726/2179 - (33%)

  Fly    11 GMFELRPLITNISCKLSAVTAGLDEKRQFLCLVSEENEILLRYISAASGQEVV--KMISW----F 69
            |...|.|..||||..|:.....:|       |:...|.:||         ||.  |:.:|    .
 Frog  1704 GWQRLAPEGTNISEPLTDCLKDVD-------LIPPFNRMLL---------EVTFGKLYAWAVQNI 1752

  Fly    70 RNRVIH-DVCFDPAGVWLLVL-CFDNTLHIVPALALVDKA-------------HGLSACSLYSTT 119
            ||.::. ..||...|:..:.| ...|.....|:|..:.:|             ||..:.:|...:
 Frog  1753 RNTLMDASSCFKEMGIQPVPLQTITNENPSGPSLGTIPQARFMLVMVNMLTCQHGAKSLNLLLNS 1817

  Fly   120 ---QVTSYIIPFVGPHECPNSKKCPN------HSTGLEESTAE--PMDQLAENLEQARLQE---- 169
               .:|..|:..:|| .|.||:...:      .:|.||||..|  |:...|...|.|.:.:
 Frog  1818 GMLALTQTILRLIGP-SCENSEDDSSVCVMGASATVLEESRKETTPVQLPASGPELAAMMKIGTR 1881

  Fly   170 ---------GEEEEP---LGH---DLPEHMLVR--------NS---GTE-----------DAVQP 197
                     |:::.|   ||.   :|.|...:|        ||   |.|           .|.|.
 Frog  1882 VMRGVDWKWGDQDGPPPGLGRVIGELGEDGWIRVQWDTGSTNSYRMGKEGKYDLKLTEPPPATQA 1946

  Fly   198 LPQQQQTIDTTGNSQV--------------------------MAASFMASKT----CPYPLSVV- 231
            :.:...|.|.:...|:                          :.|..|.|:|    |.....:|
 Frog  1947 MAEDSDTEDDSEGEQIDKNLHPTSLMLMSTVNLLQALCLSAGVNAEVMQSETTRTLCGLLRMLVE 2011

  Fly   232 ---WWKTNSGQNRAIIGYSDGSICFVGLSPN---CPMIASTAIENGSVMRLVICKDKAYDGVMLL 290
               ..||::..|:.:......|.|.:|...:   .|.:.||.    |:.:.:....|..:|....
 Frog  2012 SGTMDKTSTQSNKLVYKEQHKSWCTLGFIRSIAIMPQMCSTL----SMPQWISLLMKIVEGPESF 2072

  Fly   291 ITSSLKQQYKLLLEQKAIKYVYPGDSSPTTREGAWQIVMSVQDKHQSAATGARQSNSSDPASDSS 355
            ..:||::|   :|..:.::.|.|          :|       ||::.:.             |..
 Frog  2073 SAASLQRQ---ILAVRLLQAVLP----------SW-------DKNERSC-------------DMK 2104

  Fly   356 QLEEDVFAPPSSDDVVCSGPGAANSDPSTVSASAEAATADVPPPPAPPSYSEAVARQSGDQGGVR 420
            .|.|.:|                    |.:.:.....::|:|           :.|:|     ..
 Frog  2105 TLVEKLF--------------------SFLGSLLSTCSSDIP-----------LLRES-----TL 2133

  Fly   421 FQQQQLPAGSMDGILPATRAR--LASLKSLGSKKL------QAIKMRLSD-----QRQKFD---- 468
            .:::..|..|:.....:|.|.  :|.|::|.|...      :.|..:|:.     :.::||
 Frog  2134 RRRKARPQASLTATHSSTLAEEIVALLRTLHSLNQWNGLINKYINSQLNSVTNIFEGKRFDMTVL 2198

  Fly   469 -EFMPDS----------------------TMGSFAIMDS------PSVTPEPLGTTSGSFYNIQN 504
             ::.|||                      .:|...:.|.      ..:||:  |..:..|::::.
 Frog  2199 EDYFPDSEGPEVGSLMAVLAVIGGIDSRLRLGGQVVQDEFGEGTVTRITPK--GKITVQFHDVRT 2261

  Fly   505 LRSTFLLSALHS------NSHSL----TVHSIDISLKPLFVYKIPKHTQEILISSNILYGIHYVD 559
            .| ...|:.||.      |.::|    ::.|:...|..|...|:.||..:..:...:...:....
 Frog  2262 SR-ICPLNQLHPMPVVPFNVNNLPFTDSMLSVWAQLVNLAGCKLEKHRLKKSMRQGLTDQVDLDR 2325

  Fly   560 LHCR--------------SDSDHFTAASLLDDPLVAN----TEKENRDADIEKVDQSDVSAQ--- 603
            |.|:              |..|..  ..:|..|.|..    ...|...|..|.||.|....|
 Frog  2326 LRCQQLKLYILKAGRALLSHQDRL--RQILSQPSVQEPGLIASDEGATASPEMVDMSPEGPQPPM 2388

  Fly   604 ---KSDSTSAT--TTATSSLDQSDMPSTAINAVSVISSAMASLHTSDEDRFNNLAQLGLFRFENE 663
               :...|:||  :...:..|:.::.:.|:.....:  |:.|.|.| ...|.::..      .:|
 Frog  2389 ILLQQLLTAATQPSPVKAIFDKQELEAAALAVCQFL--AVESTHPS-TPLFEDICS------SSE 2444

  Fly   664 -----TVLHL--YQMAQYRNPSAEPETLTKEEKAKAFELKDIH---------------TP----- 701
                 |:.|:  .::.:.:.....|..:..:.....|:.|:|.               :|
 Frog  2445 ASSPVTMQHIRPAKVKKRKQSPIPPVPIVVQLMEMGFQRKNIEFALKSLSGASGTASSSPGVEAL 2509

  Fly   702 ----MDY--IQFYETADV------SSEFSLRQMEIMQSEFPKINYDPSYVITNKNVYTIQ---LK 751
                :|:  ||..|.:|.      |.|..:.::|..::.:|..|   ..|:|....|..:   |.
 Frog  2510 VGWLLDHPDIQIAELSDAETASEDSDEEIVEEVEETEASYPMAN---GAVVTESQTYKKRADFLS 2571

  Fly   752 KEPFELFLDAALQ-NEFNQCRDFCNTFDLSFE-------------------QC--IEFAGDYLLR 794
            .:.:.:::...:| ....:|   |.|::...|                   ||  .|..|.|.:|
 Frog  2572 NDDYAVYVRENVQVGMMVRC---CRTYEEVCEGDVGKVIKLDRDGLYDLNVQCDWQEKGGTYWVR 2633

  Fly   795 RKKITQALLTY------------NKARVKPIRTALKLAMYGHTYALMQLSAMALKSTYLLRSRYL 847
              .|...||.:            :|.|||...|..|...
 Frog  2634 --YIHVELLGFPPQSSPSHIKIGDKVRVKASVTTPKYKW-------------------------- 2670

  Fly   848 GHPLLKGILGDITYR----------HSEDVRVILPEK-------HEEE---DVNSGVFCSDYHYG 892
                     |.:|:|          :.:||.|..|::       .|.|   .:::||.|
 Frog  2671 ---------GSVTHRSVGVVKAFSANGKDVIVDFPQQSHWTGLLSEMELVPSIHAGVTC------ 2720

  Fly   893 VDESISALQMSP--SSQFHLANLLLITLAEKAVNDKNYIPLWNFLVT---NSKYHTNMT------ 946
                 ...||.|  .|:|..          :..:|      ::|..|   |.|::...|
 Frog  2721 -----DGCQMFPIHGSRFKC----------RVCDD------FDFCDTCFKNRKHNARHTFGRINE 2764

  Fly   947 ---SIVLC----------QSGLFSSAIILAKIRGVCLDTFNALISVVAQEFGWYNELNVC--LYN 996
               |.|.|          .||.          ||:.||.::.::..:...    :.:|..  |.:
 Frog  2765 PGQSPVFCGRSGKQLKQRHSGQ----------RGMLLDDWSRIVKSLTVS----SSVNQASRLID 2815

  Fly   997 LSENIFLETITYLPH-VSMDYFAFIQEKLHHIRPCVLQRLSKQLNP----FSPALRPIVSHNSDC 1056
            .|:..:..:.:...| :.::.|..:          .:.||...::|    :.|:|..:...||
 Frog  2816 GSDQCWQSSGSQGKHWIRLEIFPDV----------FVHRLVMTVDPADSSYMPSLVVVSGGNS-- 2868

  Fly  1057 AMSN------------DNNPQLFEFCKSLIETYLAVLIHMESQRVKYDSI------VNALSNFRI 1103
             ::|            |.|..|...|.. ...|:.:.|    ::.:...|      :|.:...|.
 Frog  2869 -LNNLIELKTININPTDLNVVLLTDCTE-YHRYIEIAI----KQCRSSGIDCKIHELNLVGQIRA 2927

  Fly  1104 ---------------NYEDNQFAIESSRFKPISAGCAYCACVVDGTAYFWGSSGIPSYYSAQKST 1153
                           :.||:..|...|..:..:||....| .:....:.||.:. .......|.:
 Frog  2928 EDEDMATVPFLASDNDEEDDDKASTGSFVRKKTAGLESTA-TIRTKVFVWGLND-KDQLGGLKGS 2990

  Fly  1154 EPPEPAHAVKSLDLLSQLNLQVHAIKCGRQHTLILTNNG-LYSLGNNNLCQLGIGRHMQMALQPM 1217
            :...|:.:    :.||.||  |..:..|.:....:|..| :|:.|.....:||:|........|.
 Frog  2991 KIKVPSFS----ETLSALN--VVQVAGGSKSLFAVTAEGKVYACGEATNGRLGLGISSGTVPIPR 3049

  Fly  1218 LVTALDG---MNITMLEAGQYHNAAVADGKLYMWGWGIYGQLGQGSCENIATPQLVSFFKFKKIL 1279
            .:|||..   ..:.:...|::..|...|||::.||.|..|:||..|..|...|:|:...|.|:|.
 Frog  3050 QITALSNYVVKKVAVHSGGRHATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIR 3114

  Fly  1280 QISLGHAHTLVLCGAPNSHMEANHCGNELFVFGSNHFGQLGTGNSDHGDTKTNLP---VRLEVGD 1341
            .|:.|.:|:..:..:           .||:.:|...:|:||     |||..|.|.   |::.:|.
 Frog  3115 DIACGSSHSAAITSS-----------GELYTWGLGEYGRLG-----HGDNTTQLKPKMVKVLLGH 3163

  Fly  1342 ------CSLRLIHTKFFTNLAVDEQDRLFTWGSSPQALRLANQIKRRANAKQKMEENQQRELLSK 1400
                  |..|...|     ||:.::..:|:||..... :|........|..|.:|....:.:.
 Frog  3164 RVIQVACGSRDAQT-----LALTDEGLVFSWGDGDFG-KLGRGGSEGCNIPQNIERLNGQAVC-- 3220

  Fly  1401 QLEATLLPAPIPSTSTLVEPTTSYAAVVAGSTPKSSVSDTKDCQDVQNEAAPSDATETIAPASAK 1465
            |:|.                    .|..:.:..||.|..|....|.......:|
 Frog  3221 QIEC--------------------GAQFSLALTKSGVVWTWGKGDYFRLGHGTD----------- 3254

  Fly  1466 AAPPPVPVASPPVLVPEPDPTEHLTPHLVDTSEVAGRILQISSGLFHFCLISSSCTLYTWGKNLE 1530
                        |.|.:|...|.|.         ..:|:.::.|..|...::.:..:|.||.|..
 Frog  3255 ------------VHVRKPQVVEGLR---------GKKIVHVAVGALHCLAVTDAGQVYAWGDNDH 3298

  Fly  1531 HQL--GTEDKDRRAVLKPSPIDSIE--RPMYVDCGSDFTLVMTTDHVVR-------AFGGNSNGQ 1584
            .|.  ||...:|    ||:.:..:|  :...|.|||..::..||..|..       .|      |
 Frog  3299 GQQGNGTTTVNR----KPTLVHGLEGQKITRVACGSSHSVAWTTVDVATPSVHEPVLF------Q 3353

  Fly  1585 CGRD-LGPSVERMRQRVVCLPATKRLVRFESQCVEVPVEINLPRPRIRLD-----QDPVRYLKVM 1643
            ..|| ||.|...:.......|::...:...|..  .|...:|.:..:.:|     |..:.:  ::
 Frog  3354 TARDALGASYLGVPSDSESSPSSSNKISGVSSL--KPNRPSLAKILLSIDGSLAKQQALSH--IL 3414

  Fly  1644 PPYQPHF--------LQPANISFDQHC---SVGTPNYKSSTEHAATGQD---SDDMLSSLENLSQ 1694
            ...|..:        |.||::.....|   |...|:..|.|.....|.|   :.|:...|.....
 Frog  3415 TALQIMYARDAVVGALMPASMIAPMECPSLSTAPPSDMSGTSSPINGDDIMLAMDLEDRLSPSPW 3479

  Fly  1695 NDASFSYNAPVLGDAHSSLDMDYTPEEQSYVPLPEQAVGSGMPANAEQLLGRDDDDGS------T 1753
            .|..        |:.:||.|          ...|.....|...|::...:...||.|:      |
 Frog  3480 QDRK--------GEVNSSED----------AVTPSAVTPSASAASSRPFIPVTDDPGAASIIAET 3526

  Fly  1754 YTQSTEGMGESSLQHLRHYIHYCLYAFHGLYNPD 1787
            .|::.|.:  .|...:......||..|..|..||
 Frog  3527 MTKTKEDV--ESQNKVTGPEPQCLDEFTSLLVPD 3558

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ca	NP_733309.3	ATS1	1181..1587	CDD:444065	95/429 (22%)
herc2	XP_012813154.2	ATS1	435..748	CDD:444065
		RCC1	735..784	CDD:395335
		Cyt-b5	1219..1291	CDD:459698
		MIB_HERC2	1879..1939	CDD:461991	11/59 (19%)
		UBA_HERC2	2471..2518	CDD:270585	5/46 (11%)
		Cul7	2566..2643	CDD:463286	15/81 (19%)
		SH3_15	2651..2708	CDD:465720	13/91 (14%)
		ZZ_HERC2	2718..2762	CDD:239084	13/70 (19%)
		APC10-HERC2	2777..2922	CDD:176485	27/176 (15%)
		ATS1	2960..3313	CDD:444065	96/440 (22%)
		ATS1	3958..4306	CDD:444065
		HECTc	4435..4806	CDD:238033