DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ca and herc5.3

DIOPT Version :9

Sequence 1:	NP_001287593.1	Gene:	ca / 43518	FlyBaseID:	FBgn0000247	Length:	1961	Species:	Drosophila melanogaster
Sequence 2:	XP_021330683.1	Gene:	herc5.3 / 100073325	ZFINID:	ZDB-GENE-070615-14	Length:	1002	Species:	Danio rerio

Alignment Length:	804	Identity:	160/804 - (19%)
Similarity:	266/804 - (33%)	Gaps:	277/804 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly  1120 ISAGCAYCACVVDGTAYFWGSSGIPSYYSAQKSTEPPE------------PAHAVKSLD------ 1166
            ||.|.:|...:.:|||:......    ..|.:..||.:            .|.||...|
Zfish    45 ISTGKSYVGFIREGTAWILRLHN----EDADEKLEPLQLQNERIRSIVCGEAGAVLLADDGKVLV 105

  Fly  1167 ---------LLSQLNLQVHAIKCGRQHTLILTNNG-LYSLGNNNLCQLGIGRHMQMALQPMLVTA 1221
                     |....|.||..|.||.||::.|||:| |:..|.|.|.|||:.:.......|..:.:
Zfish   106 MDQSTVCRPLKGLENRQVIQIACGDQHSMALTNDGQLFVWGENALGQLGLRKEQAGTQSPQHLQS 170

  Fly  1222 LDGMNITMLEAGQYHNAAVA-DGKLYMWGWGIYGQLGQGSCENIATPQLVSFFKFKKILQISLGH 1285
            |.|:.:..:.||..|:..:: .|.::.||....||||.|...:...|.:|.....||.:.||.|.
Zfish   171 LCGIPVAQISAGGNHSFVLSLSGVVFGWGSNSAGQLGLGDTTDRFIPTIVKSLSGKKTVSISCGG 235

  Fly  1286 AHTLVLCGAPNSHMEANHCGNELFVFGSNHFGQLGTGNSDHGDTKTNLPVRL-------EVGDCS 1343
            .||..|..           |..:|.|||..|||||     |...|.....||       :|...:
Zfish   236 EHTATLSK-----------GGTVFTFGSGGFGQLG-----HNSLKDEHHPRLVAELWGSKVSQVT 284

  Fly  1344 LRLIHTKFFTNLAVDEQDRLFTWGSSPQALRLAN--QIKRRANAKQKMEENQQRELLSKQLEATL 1406
            ....||..|.    |..::::::|...|. :|.|  |:|                      ::..
Zfish   285 CGRHHTLVFE----DSSNQIYSFGCGMQG-QLGNGEQVK----------------------QSVP 322

  Fly  1407 LPAPIPSTSTLVEPTTSYAAVVAGST----------------PKSSVSD---TKDCQDVQNEAAP 1452
            ||..:|:..|    ..:...::||..                |||..:.   |.:.:.:....:.
Zfish   323 LPVLLPTECT----EFTMEKLIAGENHSFALFFKSPGNESEKPKSGSNGGILTLNDRIIDRWVSE 383

  Fly  1453 SDATETIAPASAKAAPPPVPVASPPVLVPEPDPTEHLTPHLVDTSEVAGRILQISSGLFHFCLIS 1517
            ||                          |.|.....:.......:.:.|..|:.|..
Zfish   384 SD--------------------------PWPTIKNEINTVFSSAASLNGSFLKTSRD-------- 414

  Fly  1518 SSCTLYTWGKNLEHQLGTEDKDRRAVLKPSPIDSIERPMYVDCGSDFTLVMTT-----------D 1571
                        ||..                .|:||     ||.||.||.|:           .
Zfish   415 ------------EHYQ----------------TSVER-----CGLDFDLVKTSFAKLSTSKSLIS 446

  Fly  1572 HVVR--------AFGGNSNGQCG-------RDLGPSVERMRQRVV----------CLPATKRLVR 1611
            .||:        :...|..|:..       .:|...:::.|.:::          | ||.::::.
Zfish   447 EVVKVVQQTLLPSLNPNPTGEEALRLYLLLPELINGLKKQRTKLIEALAFKILELC-PAARKVLE 510

  Fly  1612 -----------------FESQCVEVPVEINLPRPRIRLDQDPVRYLKVMPPYQPHFLQPANISFD 1659
                             |..:..|:..:|:    |...|....|:||       :||:...:::.
Zfish   511 MYWSRLPDDWFEALIKLFHKESAELIKQIS----RGETDDQSTRHLK-------NFLEILQMAYQ 564

  Fly  1660 QHCSVGTPNYKSSTEHAATGQDSDDMLSSLENLSQNDASFSYNAPVLGDAHSSLDM--------- 1715
            ..||.      :.|.|.....:.:|:|.:|:..|......:...|:..:.|:.:.:
Zfish   565 ICCST------NITNHDFIIPEVNDLLETLDATSAEVLWMASRLPINEELHNRMKLEDYYFKTAE 623

  Fly  1716 ---------DYTPEEQSYVPLPEQAVGSGMPANAEQLLGRDDDDGSTYTQSTEGMGESSLQHLR- 1770
                     |:..::..::.|.||.:.|.:......|      :|:....:.|.:...:||:||
Zfish   624 ILVKFPFVSDFLTKKSMFILLQEQCIRSLLDLLVVHL------NGNLLHINRESVLTDTLQYLRP 682

  Fly  1771 ---HYIHYCLYAFHGLYNPDKIGE 1791
               .::|....||.|   .|:|.|
Zfish   683 FTYSFMHPLQVAFIG---EDEIDE 703

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ca	NP_001287593.1	ATS1	1158..1588	CDD:227511	106/500 (21%)
		RCC1_2	1175..1200	CDD:290274	12/25 (48%)
		RCC1	1193..1240	CDD:278826	13/46 (28%)
		RCC1	1242..1291	CDD:278826	17/48 (35%)
		RCC1_2	1503..1532	CDD:290274	3/28 (11%)
		RCC1	1522..1568	CDD:278826	10/45 (22%)
		RCC1_2	1558..1584	CDD:290274	10/44 (23%)
herc5.3	XP_021330683.1	RCC1	<74..349	CDD:332518	81/321 (25%)
herc5.3	XP_021330683.1	HECTc	665..1000	CDD:331829	12/42 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010