DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ncd and KIFC2

DIOPT Version :9

Sequence 1:	NP_001287592.1	Gene:	ncd / 43517	FlyBaseID:	FBgn0002924	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	NP_665697.1	Gene:	KIFC2 / 90990	HGNCID:	29530	Length:	838	Species:	Homo sapiens

Alignment Length:	732	Identity:	197/732 - (26%)
Similarity:	315/732 - (43%)	Gaps:	191/732 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 LERRGGGARAASPEPMKLGHRAKLRRSRSACDI------NELRGNKRTAAAPSLPSIPSKVSRLG 126
            |.||.||| ||:.||.....||:..|.|...|:      .||.|    .||.|.|...|:.:..|
Human    15 LFRRDGGA-AAAAEPGDPAQRARKPRGRRRPDLPAPELWTELTG----LAASSEPEDGSEGAAEG 74

  Fly   127 GALTVS-SQRLVR-----------------PA-------APSSITAT-------AVKRPP----- 154
            .|..|| .:.|:|                 ||       .||.:|.|       |..|.|
Human    75 RAAAVSLEEALLRLAEFLSVQLGAEESCGGPADLGQSGEVPSLLTVTSQLLALLAWLRSPRGRQA 139

  Fly   155 ---VTRPAPR----AAGGAAAKKPAGTGAAASSG------AAAAAPKRIAPYDFKA--RFHDL-L 203
               .|:||||    :..|:.:::.:.:...|..|      .....|.::.. |.:|  |...| |
Human   140 LLQGTQPAPRVRPPSPDGSTSQEESPSHFTAVPGEPLGDETQGQQPLQLEE-DQRAWQRLEQLIL 203

  Fly   204 EKHKVLKTKYEKQTEDMGEL--------------------ESMPQQL------------------ 230
            .:.:.||.:.|:|.|::|.|                    |::.|.|
Human   204 GQLEELKQQLEQQEEELGRLRLGVGATDSEKRVQHLTLENEALKQSLSLMRDLLLHWGPGPPIRA 268

  Fly   231 -EETQNKLIETESSLKNTQSDNECLQRQVKQHTAKIETITSTLGRTKEELS-----ELQAIHEKV 289
             :|....|:|.:..|:..|...|.|:.|:.....:::.:...|.:.::|..     |||.:|.::
Human   269 PQEEAEALLELQGRLQEAQDTTEALRAQLGVQEVQLQGLQGALQQLQQETEQNCRRELQQMHGQL 333

  Fly   290 KTEHAALSTEVVHLRQRTEELLRCNEQQ---AAELETCKEQLFQSNMERKELH------------ 339
                |.|...:..|||      .|.:.:   :...::|:..|.::   |.::.
Human   334 ----AGLRARMASLRQ------GCGDLRGLVSTFTQSCQGSLSEA---RGQVSWALGALSSGGPG 385

  Fly   340 ---------------NTVMDLRGNIRVFCRIRPPLESEENRMCCTWTYHDESTVELQ-----SID 384
                           ..:.:|:|||||.||:||...|              |.|.::     ::.
Human   386 TQLPEGQQGPPAGCPGRLPELKGNIRVLCRLRPGTSS--------------SLVSVEPGPGGTVT 436

  Fly   385 AQAKSKMGQQIFSFDQVFHPLSSQSDIFEMVSPLIQSALDGYNICIFAYGQTGSGKTYTMDGVPE 449
            ...:.:  .:.|..|.||.|.:||.::|..:.|.:.|.|.||::|||.|||||:||||:|:|.||
Human   437 TCYRGR--HRRFRLDWVFPPDASQEEVFRELEPAVLSCLRGYSVCIFTYGQTGTGKTYSMEGPPE 499

  Fly   450 SVGVIPRTVDLLFDSIRGYRNLGWEYEIKATFLEIYNEVLYDLLS-NEQKDMEIRMAKNNKNDIY 513
            ..|::||.:..||..:    ..|.::.:..:.:|||||.:.|||: ...:.:.:|.....:..|.
Human   500 DPGIVPRALQSLFREM----GAGRQHRVTLSMVEIYNEAVRDLLAPGPPERLAVRQGPEGQGGIQ 560

  Fly   514 VSNITEETVLDPNHLRHLMHTAKMNRATASTAGNERSSRSHAVTKLELIGRHAEKQEISVGSINL 578
            |:.:|...|.:...|..::...:.|||||:||.|:|||||||:..|.|......:...:.|:::|
Human   561 VAGLTHWDVPNLETLHQMLKLGRSNRATAATAMNQRSSRSHALVTLTLRAASPPRAPGTAGTLHL 625

  Fly   579 VDLAGSE-------------SPKTSTRMTETKNINRSLSELTNVILALLQKQDHIPYRNSKLTHL 630
            |||||||             .|..:.|:.|.:.|||||..|..|:.||...:.|:|:|:|:||.|
Human   626 VDLAGSERARKAGAAGPPRGDPDGARRLREAQTINRSLLALGGVMAALRAHRPHVPFRDSQLTRL 690

  Fly   631 LMPSLGGNSKTLMFINV 647
            |.|:||..:..::.:.|
Human   691 LQPALGPGTTAVLLLQV 707

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ncd	NP_001287592.1	KISc_C_terminal	346..672	CDD:276817	111/321 (35%)
ncd	NP_001287592.1	KISc	348..678	CDD:214526	110/319 (34%)
KIFC2	NP_665697.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	23..48		9/24 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	140..185		8/44 (18%)
		Motor_domain	407..707	CDD:277568	110/319 (34%)
		KISc	409..707	CDD:214526	109/317 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	718..792
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0239
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D181609at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820