DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ncd and KAR3

DIOPT Version :9

Sequence 1:	NP_001287592.1	Gene:	ncd / 43517	FlyBaseID:	FBgn0002924	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	NP_015467.1	Gene:	KAR3 / 856263	SGDID:	S000006345	Length:	729	Species:	Saccharomyces cerevisiae

Alignment Length:	542	Identity:	199/542 - (36%)
Similarity:	290/542 - (53%)	Gaps:	84/542 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   205 KHKVLKTKYEKQTEDMGELESMPQQLEETQNKLIETESSLKNTQSDNE---CLQRQV-------- 258
            |.|:.|.|:.|..:...|..|:..::||.:||:....|:|:...:|.|   .|:::.
Yeast   202 KTKIEKLKFMKIKQFENERASLLDKIEEVRNKITMNPSTLQEMLNDVEQKHMLEKEEWLTEYQSQ 266

  Fly   259 --------KQHTAKIETITSTLGRT-KEELSE-----------LQAIHEKVK---TEHAALSTEV 300
                    .:|..:||:|...:..| |.||:|           .:||..|||   .|...|..||
Yeast   267 WKKDIELNNKHMQEIESIKKEIENTLKPELAEKKKLLTEKRNAYEAIKVKVKEKEEETTRLRDEV 331

  Fly   301 VHLRQRT-----------EELLRCNEQQAAELETCKEQLFQSNMERKELHNTVMDLRGNIRVFCR 354
            . |:|:|           ||.::..|....||   .|.|.:....|:.|||.:.:|||||||:||
Yeast   332 A-LKQKTNLETLEKIKELEEYIKDTELGMKEL---NEILIKEETVRRTLHNELQELRGNIRVYCR 392

  Fly   355 IRPPLESEENRMCCTWTYHDESTVELQSIDAQA--------KSKMGQQI--FSFDQVFHPLSSQS 409
            |||.|::.||        .|.|.:.:...|..:        |.:...|:  |.||::|....:..
Yeast   393 IRPALKNLEN--------SDTSLINVNEFDDNSGVQSMEVTKIQNTAQVHEFKFDKIFDQQDTNV 449

  Fly   410 DIFEMVSPLIQSALDGYNICIFAYGQTGSGKTYTMDGVPESVGVIPRTVDLLFDSIRGYRNLGWE 474
            |:|:.|..|:||:|||||:|||||||||||||:||  :....|:||.|:..:|:.|...:..||:
Yeast   450 DVFKEVGQLVQSSLDGYNVCIFAYGQTGSGKTFTM--LNPGDGIIPSTISHIFNWINKLKTKGWD 512

  Fly   475 YEIKATFLEIYNEVLYDLL---SNEQKDMEIRMAKNNKND-----IYVSNITEETVLDPNHLRHL 531
            |::...|:|||||.:.|||   :|.::|..|.:....::|     ..::|:|...:.....:..:
Yeast   513 YKVNCEFIEIYNENIVDLLRSDNNNKEDTSIGLKHEIRHDQETKTTTITNVTSCKLESEEMVEII 577

  Fly   532 MHTAKMNRATASTAGNERSSRSHAVTKLELIGRHAEKQEISVGSINLVDLAGSE----SPKTSTR 592
            :..|...|:|||||.||.|||||::..:.|.|.:|:....|.|::|||||||||    |.....|
Yeast   578 LKKANKLRSTASTASNEHSSRSHSIFIIHLSGSNAKTGAHSYGTLNLVDLAGSERINVSQVVGDR 642

  Fly   593 MTETKNINRSLSELTNVILALLQKQD---HIPYRNSKLTHLLMPSLGGNSKTLMFINVSPFQDCF 654
            :.||:|||:|||.|.:||.||.|...   |||:||||||:||..||.|:||||||:|:||.....
Yeast   643 LRETQNINKSLSCLGDVIHALGQPDSTKRHIPFRNSKLTYLLQYSLTGDSKTLMFVNISPSSSHI 707

  Fly   655 QESVKSLRFAASVNSCKMTKAK 676
            .|::.|||||:.|||.::...|
Yeast   708 NETLNSLRFASKVNSTRLVSRK 729

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ncd	NP_001287592.1	KISc_C_terminal	346..672	CDD:276817	149/350 (43%)
ncd	NP_001287592.1	KISc	348..678	CDD:214526	148/354 (42%)
KAR3	NP_015467.1	Smc	98..>387	CDD:224117	51/188 (27%)
KAR3	NP_015467.1	KISc_C_terminal	384..725	CDD:276817	149/350 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	232	1.000	Domainoid score	I404
eggNOG	1	0.900	-	-		E2759_KOG0239
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	281	1.000	Inparanoid score	I558
Isobase	1	0.950	-	0	Normalized mean entropy	S1681
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000325
OrthoInspector	1	1.000	-	-		oto99953
orthoMCL	1	0.900	-	-		OOG6_101893
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1242
TreeFam	0	0.000	Not matched by this tool.
	10	9.710