DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ncd and ZWI

DIOPT Version :9

Sequence 1:	NP_001287592.1	Gene:	ncd / 43517	FlyBaseID:	FBgn0002924	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	NP_001190628.1	Gene:	ZWI / 836723	AraportID:	AT5G65930	Length:	1266	Species:	Arabidopsis thaliana

Alignment Length:	526	Identity:	178/526 - (33%)
Similarity:	268/526 - (50%)	Gaps:	53/526 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   201 DLLEKHKVLKTKYEKQTEDMGELESMPQQLEETQNKLIETESSLKNTQSDNECLQRQVKQHTAKI 265
            :|..::|.|....:.....:.|.:.:.|.|...:.|..|.|...|..:.:.:.|:.:|.:...|:
plant   744 ELEVRNKELHVAVDNSKRLLSENKILEQNLNIEKKKKEEVEIHQKRYEQEKKVLKLRVSELENKL 808

  Fly   266 ETITSTLGRTKEEL----SELQAIHEKVKTEHAALSTEVVHLRQRTEELLRCNEQQAAELETCKE 326
            |.:...|...:..:    |::..:...:|        |:..||:..|::.|.|||.||.|:....
plant   809 EVLAQDLDSAESTIESKNSDMLLLQNNLK--------ELEELREMKEDIDRKNEQTAAILKMQGA 865

  Fly   327 QLF-------QSNMERKELHNTVMDLRGNIRVFCRIRPPLESE----ENRMCCTWTYHDESTVEL 380
            ||.       :..:.||..:||:.|::|.|||:|||||..|.|    |.:|..|   .||.|||.
plant   866 QLAELEILYKEEQVLRKRYYNTIEDMKGKIRVYCRIRPLNEKESSEREKQMLTT---VDEFTVEH 927

  Fly   381 QSIDAQAKSKMGQQIFSFDQVFHPLSSQSDIFEMVSPLIQSALDGYNICIFAYGQTGSGKTYTMD 445
            ...|.:.|..:      :|:||...:||.||||....|:|||:||||:|||||||||||||:|:.
plant   928 PWKDDKRKQHI------YDRVFDMRASQDDIFEDTKYLVQSAVDGYNVCIFAYGQTGSGKTFTIY 986

  Fly   446 GVPESVGVIPRTVDLLF-----DSIRGYRNLGWEYEIKATFLEIYNEVLYD-LLSNEQKDMEIRM 504
            |...:.|:.||....||     ||.|      :.:.:||..:|:|.:.|.| ||....:.:::.:
plant   987 GHESNPGLTPRATKELFNILKRDSKR------FSFSLKAYMVELYQDTLVDLLLPKSARRLKLEI 1045

  Fly   505 AKNNKNDIYVSNITEETVLDPNHLRHLMHTAKMNRATASTAGNERSSRSHAVTKLELIGRHAEKQ 569
            .|::|..::|.|:|...:.....||.::......|..:.|..||.|||||.:..:.:.....:.|
plant  1046 KKDSKGMVFVENVTTIPISTLEELRMILERGSERRHVSGTNMNEESSRSHLILSVVIESIDLQTQ 1110

  Fly   570 EISVGSINLVDLAGSESPKTS----TRMTETKNINRSLSELTNVILALLQKQDHIPYRNSKLTHL 630
            ..:.|.::.|||||||..|.|    .::.|.::||:|||.|.:||.||.....||||||.|||.|
plant  1111 SAARGKLSFVDLAGSERVKKSGSAGCQLKEAQSINKSLSALGDVIGALSSGNQHIPYRNHKLTML 1175

  Fly   631 LMPSLGGNSKTLMFINVSPFQDCFQESVKSLRFAASVNS-----CKMTKAKRNRYLNNSVANSST 690
            :..|||||:|||||:||||.:....|:..||.:|:.|.:     .|...:|....|...||....
plant  1176 MSDSLGGNAKTLMFVNVSPAESNLDETYNSLLYASRVRTIVNDPSKHISSKEMVRLKKLVAYWKE 1240

  Fly   691 QSNNSG 696
            |:...|
plant  1241 QAGKKG 1246

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ncd	NP_001287592.1	KISc_C_terminal	346..672	CDD:276817	136/344 (40%)
ncd	NP_001287592.1	KISc	348..678	CDD:214526	137/348 (39%)
ZWI	NP_001190628.1	MyTH4	121..280	CDD:214535
		B41	289..505	CDD:214604
		FERM_N	289..363	CDD:286467
		FERM_M	402..506	CDD:278785
		FERM_C_KCBP	502..608	CDD:270021
		Microtub_bd	876..>901	CDD:293401	10/24 (42%)
		KISc_C_terminal	892..1217	CDD:276817	136/339 (40%)
		KISc	895..1222	CDD:214526	135/341 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0239
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D364605at2759
OrthoFinder	1	1.000	-	-		FOG0000325
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820