DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ncd and ATK3

DIOPT Version :9

Sequence 1:	NP_001287592.1	Gene:	ncd / 43517	FlyBaseID:	FBgn0002924	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	NP_001330580.1	Gene:	ATK3 / 835556	AraportID:	AT5G54670	Length:	754	Species:	Arabidopsis thaliana

Alignment Length:	533	Identity:	198/533 - (37%)
Similarity:	306/533 - (57%)	Gaps:	66/533 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   201 DLLEKHKVLKTKYEKQT---EDMGELESMPQQLEE-------TQNKLIETESSLKNTQSDNECLQ 255
            ||.|.|:.:|...:::|   |::|.|:.....|:|       :|..:::.:..|.|..:..:...
plant   218 DLDEAHETIKRGEKERTAIIENIGNLKGQFSALQEQLAASKASQEDIMKQKGELVNEIASLKVEL 282

  Fly   256 RQVK----QHTAKIETITSTLGR---TKEELSELQAIHEKVKTEHAALSTEVVHLRQR------- 306
            :|||    :|..:::|:.:...:   .|:.::||:.......|:...|...:|:..:|
plant   283 QQVKDDRDRHLVEVKTLQTEATKYNDFKDAITELETTCSSQSTQIRQLQDRLVNSERRLQVSDLS 347

  Fly   307 TEELLRCNEQQ-------AAELETCKEQLFQSNMERKELHNTVMDLRGNIRVFCRIRPPLESEEN 364
            |.|.:...|.|       .:.:|..:.:|.:....||:||||:::|:||||||||:||.|..|.|
plant   348 TFEKMNEYEDQKQSIIDLKSRVEEAELKLVEGEKLRKKLHNTILELKGNIRVFCRVRPLLPGENN 412

  Fly   365 RMCCTWTYHDE-------STVEL--QSIDAQAKSKMGQQIFSFDQVFHPLSSQSDIFEMVSPLIQ 420
                    .||       :::|.  :.||....::  :..|:||:||.|.:||.|:|..:|.|:|
plant   413 --------GDEGKTISYPTSLEALGRGIDLMQNAQ--KHAFTFDKVFAPTASQEDVFTEISQLVQ 467

  Fly   421 SALDGYNICIFAYGQTGSGKTYTMDGVP---ESVGVIPRTVDLLFDSIRGYRNLGWEYEIKATFL 482
            ||||||.:||||||||||||||||.|.|   |..|:|||.::.:|::.:..|:.||:||::.:.|
plant   468 SALDGYKVCIFAYGQTGSGKTYTMMGRPGNVEEKGLIPRCLEQIFETRQSLRSQGWKYELQVSML 532

  Fly   483 EIYNEVLYDLLSNEQK----DMEIRMAKNN-KNDIY-VSNITEETVLDPNHLRH---LMHTAKMN 538
            |||||.:.||||..::    |..:...|:. |:|.. .:::.|.|:||....|.   |:..|..|
plant   533 EIYNETIRDLLSTNKEAVRTDSGVSPQKHAIKHDASGNTHVAELTILDVKSSREVSFLLDHAARN 597

  Fly   539 RATASTAGNERSSRSHAVTKLELIGRHAEKQEISVGSINLVDLAGSE----SPKTSTRMTETKNI 599
            |:...|..||:|||||.|..|.:.|.:...::...|.:||:||||||    |..|..|:.||:.|
plant   598 RSVGKTQMNEQSSRSHFVFTLRISGVNESTEQQVQGVLNLIDLAGSERLSKSGSTGDRLKETQAI 662

  Fly   600 NRSLSELTNVILALLQKQDHIPYRNSKLTHLLMPSLGGNSKTLMFINVSPFQDCFQESVKSLRFA 664
            |:|||.|.:||.||.:|:||:|:||||||:||.|.|||::|||||:|::|......||:.|||||
plant   663 NKSLSSLGDVIFALAKKEDHVPFRNSKLTYLLQPCLGGDAKTLMFVNIAPESSSTGESLCSLRFA 727

  Fly   665 ASVNSCKMTKAKR 677
            |.||:|::...:|
plant   728 ARVNACEIGTPRR 740

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ncd	NP_001287592.1	KISc_C_terminal	346..672	CDD:276817	158/350 (45%)
ncd	NP_001287592.1	KISc	348..678	CDD:214526	158/355 (45%)
ATK3	NP_001330580.1	Smc	46..>341	CDD:224117	25/122 (20%)
ATK3	NP_001330580.1	KISc_C_terminal	394..735	CDD:276817	158/350 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	248	1.000	Domainoid score	I532
eggNOG	1	0.900	-	-		E2759_KOG0239
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H83229
Inparanoid	1	1.050	302	1.000	Inparanoid score	I778
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D364605at2759
OrthoFinder	1	1.000	-	-		FOG0000325
OrthoInspector	1	1.000	-	-		otm2680
orthoMCL	1	0.900	-	-		OOG6_101893
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1242
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.730