DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ncd and ATK4

DIOPT Version :9

Sequence 1:	NP_001287592.1	Gene:	ncd / 43517	FlyBaseID:	FBgn0002924	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	NP_568491.1	Gene:	ATK4 / 832758	AraportID:	AT5G27000	Length:	987	Species:	Arabidopsis thaliana

Alignment Length:	530	Identity:	186/530 - (35%)
Similarity:	282/530 - (53%)	Gaps:	69/530 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   205 KHK----VLKTKYEKQTEDMGELESMPQQLEETQNKLI-ETESSLKNTQSDNECLQRQVKQHTAK 264
            ||:    |:::...|..|::.:..|:..::.::.:|.| |.:||.:.......|..||.::
plant   237 KHEDIPNVVESVLNKVMEEVQQRLSIHNEMMKSSSKPIPEDDSSCETVVRSQLCDARQHEE---- 297

  Fly   265 IETITSTLGRTKEELSELQAIHEKVK-------TEHAALSTEVVHLRQRTE---------ELLRC 313
                       .||.|..|.:.:|.:       .|...|..:..|:::..:         :||:.
plant   298 -----------AEENSPPQVVEKKFQRTNFEHHEEQKILLNQQKHIQELKQTLYTTKAGMKLLQM 351

  Fly   314 NEQQ-----------AAELETCKEQLFQSNMERKELHNTVMDLRGNIRVFCRIRPPLESEENRMC 367
            ..|:           .|...|..:::.:.|   ::|:|.|.||:|||||:||:||.|..:|:...
plant   352 KYQEDFFHLGKHLNGLAYAATGYKRVLEEN---RKLYNLVQDLKGNIRVYCRVRPFLPGQESGGL 413

  Fly   368 CTWTYHDESTVELQSIDAQAK-SKMGQQIFSFDQVFHPLSSQSDIFEMVSPLIQSALDGYNICIF 431
            ......||.|:   :|...:| .|.||:.|.|::||.|.::|.::|..:.||::|.|||||:|||
plant   414 SAVEDIDEGTI---TIRVPSKYGKAGQKPFMFNKVFGPSATQEEVFSDMQPLVRSVLDGYNVCIF 475

  Fly   432 AYGQTGSGKTYTMDG----VPESVGVIPRTVDLLFDSIRGYRNLGWEYEIKATFLEIYNEVLYDL 492
            ||||||||||:||.|    ..||:||..|.:..|| .:...|.....|||....||||||.:.||
plant   476 AYGQTGSGKTFTMTGPKELTEESLGVNYRALADLF-LLSNQRKDTTSYEISVQMLEIYNEQVRDL 539

  Fly   493 LSNEQKDMEIRMAKNNKNDIYVSNITEETVLDPNHLRHLMHTAKMNRATASTAGNERSSRSHAVT 557
            |:.:.:...:.:..|:.|.|.|...:...|...:.:..||....||||.:|||.|:||||||:..
plant   540 LAQDGQTKRLEIRNNSHNGINVPEASLVPVSSTDDVIQLMDLGHMNRAVSSTAMNDRSSRSHSCV 604

  Fly   558 KLELIGRHAEKQEISVGSINLVDLAGSE----SPKTSTRMTETKNINRSLSELTNVILALLQKQD 618
            .:.:.||......|..||::||||||||    |..|..|:.|.::||:|||.|.:||.:|.||..
plant   605 TVHVQGRDLTSGSILHGSMHLVDLAGSERVDKSEVTGDRLKEAQHINKSLSALGDVISSLSQKTS 669

  Fly   619 HIPYRNSKLTHLLMPSLGGNSKTLMFINVSPFQDCFQESVKSLRFAASVNSCKMTKAKRN----- 678
            |:||||||||.||..||||::|||||:::||..|...|::.:|:||..|.|.::..|:.|
plant   670 HVPYRNSKLTQLLQDSLGGSAKTLMFVHISPEPDTLGETISTLKFAERVGSVELGAARVNKDNSE 734

  Fly   679 -RYLNNSVAN 687
             :.|...:||
plant   735 VKELKEQIAN 744

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ncd	NP_001287592.1	KISc_C_terminal	346..672	CDD:276817	148/334 (44%)
ncd	NP_001287592.1	KISc	348..678	CDD:214526	148/338 (44%)
ATK4	NP_568491.1	CH	46..158	CDD:278723
		KISc_C_terminal	392..723	CDD:276817	148/334 (44%)
		KISc	394..727	CDD:214526	147/336 (44%)
		DUF4887	<841..977	CDD:292845
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0239
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D364605at2759
OrthoFinder	1	1.000	-	-		FOG0000325
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820