DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ncd and ATK1

DIOPT Version :9

Sequence 1:	NP_001287592.1	Gene:	ncd / 43517	FlyBaseID:	FBgn0002924	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	NP_193859.1	Gene:	ATK1 / 827876	AraportID:	AT4G21270	Length:	793	Species:	Arabidopsis thaliana

Alignment Length:	567	Identity:	205/567 - (36%)
Similarity:	306/567 - (53%)	Gaps:	87/567 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   188 KRIAPYD-----FKARFHDLLEKHKVLKTKYEKQTEDM--------GELESMPQQLEET---QNK 236
            ||:..|:     :.::....||..:...|:.||:...:        |..:|:..||..:   |:.
plant   223 KRLQEYNTSLQQYNSKLQTDLETVRAALTRAEKEKSSILENLSTLRGHSKSLQDQLSSSRVLQDD 287

  Fly   237 LIETESSLKN--TQSDNECLQ------RQVKQH------------------------TAKIETIT 269
            .|:.:.||.:  |...||..|      |||.|.                        |||..::.
plant   288 AIKQKDSLLSEVTNLRNELQQVRDDRDRQVVQSQKLSEEIRKYQENVGKSSQELDILTAKSGSLE 352

  Fly   270 STLGRTKEELS----ELQAIHEKVKTEHAALSTEVVHLRQRTE----ELLRCN-EQQAAELETCK 325
            .|....||.|:    :|...:|:.|...|::|.      .|||    :.|.|. :.:.|::|
plant   353 ETCSLQKERLNMLEQQLAIANERQKMADASVSL------TRTEFEEQKHLLCELQDRLADME--- 408

  Fly   326 EQLFQSNMERKELHNTVMDLRGNIRVFCRIRPPLESEENRMCCTWTYHDESTVELQSIDAQAKSK 390
            .||.:..:.||:||||:::|:||||||||:||.|..:..|...|...:..|| |.|.........
plant   409 HQLCEGELLRKKLHNTILELKGNIRVFCRVRPLLPDDGGRHEATVIAYPTST-EAQGRGVDLVQS 472

  Fly   391 MGQQIFSFDQVFHPLSSQSDIFEMVSPLIQSALDGYNICIFAYGQTGSGKTYTMDGVPES---VG 452
            ..:..|:||:||:..:||.::|..:|.|:|||||||.:||||||||||||||||.|.||:   .|
plant   473 GNKHPFTFDKVFNHEASQEEVFFEISQLVQSALDGYKVCIFAYGQTGSGKTYTMMGRPEAPDQKG 537

  Fly   453 VIPRTVDLLFDSIRGYRNLGWEYEIKATFLEIYNEVLYDLLS-NEQKDMEIRMAKNN-------- 508
            :|||:::.:|.:.:.....||:|:::.:.||||||.:.|||| |....|::..|.:.
plant   538 LIPRSLEQIFQASQSLGAQGWKYKMQVSMLEIYNETIRDLLSTNRTTSMDLVRADSGTSGKQYTI 602

  Fly   509 KNDI----YVSNITEETVLDPNHLRHLMHTAKMNRATASTAGNERSSRSHAVTKLELIGRHAEKQ 569
            .:|:    :||::|...|.....:..|:..|..:|:...|..||:|||||.|..:.:.|.:...:
plant   603 THDVNGHTHVSDLTIFDVCSVGKISSLLQQAAQSRSVGKTQMNEQSSRSHFVFTMRISGVNESTE 667

  Fly   570 EISVGSINLVDLAGSE----SPKTSTRMTETKNINRSLSELTNVILALLQKQDHIPYRNSKLTHL 630
            :...|.:||:||||||    |..|..|:.||:.||:|||.|::||.||.:|:||:|:||||||:|
plant   668 QQVQGVLNLIDLAGSERLSKSGATGDRLKETQAINKSLSALSDVIFALAKKEDHVPFRNSKLTYL 732

  Fly   631 LMPSLGGNSKTLMFINVSPFQDCFQESVKSLRFAASVNSCKMTKAKR 677
            |.|.|||:||||||:|:||......||:.||||||.||:|::...:|
plant   733 LQPCLGGDSKTLMFVNISPDPTSAGESLCSLRFAARVNACEIGIPRR 779

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ncd	NP_001287592.1	KISc_C_terminal	346..672	CDD:276817	152/345 (44%)
ncd	NP_001287592.1	KISc	348..678	CDD:214526	152/350 (43%)
ATK1	NP_193859.1	Smc	<116..433	CDD:224117	54/218 (25%)
ATK1	NP_193859.1	KISc_C_terminal	429..774	CDD:276817	152/345 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	248	1.000	Domainoid score	I532
eggNOG	1	0.900	-	-		E2759_KOG0239
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H83229
Inparanoid	1	1.050	302	1.000	Inparanoid score	I778
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D364605at2759
OrthoFinder	1	1.000	-	-		FOG0000325
OrthoInspector	1	1.000	-	-		otm2680
orthoMCL	1	0.900	-	-		OOG6_101893
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1242
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.730