DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ncd and ATK5

DIOPT Version :9

Sequence 1:	NP_001287592.1	Gene:	ncd / 43517	FlyBaseID:	FBgn0002924	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	NP_192428.2	Gene:	ATK5 / 825867	AraportID:	AT4G05190	Length:	790	Species:	Arabidopsis thaliana

Alignment Length:	569	Identity:	197/569 - (34%)
Similarity:	301/569 - (52%)	Gaps:	87/569 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   188 KRIAPYD-----FKARFHDLLEKHKVLKTKYEKQTEDM--------GELESMPQQLEE---TQNK 236
            ||:..|:     :..:....||..:...|:.||:...:        |..:|:..||..   :|::
plant   220 KRLQEYNTSLQQYNTKLQTDLEVAREAHTRAEKEKSSILENLTTLRGHSKSLQDQLASSRVSQDE 284

  Fly   237 LIETESSL----KNTQSDNECLQRQVKQHTAKIETIT-------STLGRTKEEL----------- 279
            .::.:.||    .|.||:.:.::....:|..:.:.:.       .::|::..||
plant   285 AVKQKDSLLMEVNNLQSELQQVRDDRDRHVVQSQKLAGEILMYKESVGKSSHELDILIAKSGSLE 349

  Fly   280 --------------SELQAIHEKVKTEHAALSTEVVHLRQRTEELLRCNEQQAAELETCKEQLFQ 330
                          .||....||:|....::|    |.....||..:|..:....|...:.|||:
plant   350 ETCSLQKERIKMLEQELAFAKEKLKMVDLSMS----HTMTEFEEQKQCMHELQDRLADTERQLFE 410

  Fly   331 SNMERKELHNTVMDLRGNIRVFCRIRPPLESEENRMCCTWTYHDESTVEL-QSID-AQAKSKMGQ 393
            ..:.||:||||:::|:||||||||:||.|..:..|...:...:..||..| :.|| .|:.:|
plant   411 GELLRKKLHNTILELKGNIRVFCRVRPLLPDDGGRQEASVIAYPTSTESLGRGIDVVQSGNK--- 472

  Fly   394 QIFSFDQVFHPLSSQSDIFEMVSPLIQSALDGYNICIFAYGQTGSGKTYTMDG---VPESVGVIP 455
            ..|:||:||...:||.::|..:|.|:|||||||.:||||||||||||||||.|   .||..|:||
plant   473 HPFTFDKVFDHGASQEEVFFEISQLVQSALDGYKVCIFAYGQTGSGKTYTMMGRPETPEQKGLIP 537

  Fly   456 RTVDLLFDSIRGYRNLGWEYEIKATFLEIYNEVLYDLLSNEQ-------------KDMEIRMAKN 507
            |:::.:|.:.:.....||:|:::.:.||||||.:.||||..:             ...:..:..:
plant   538 RSLEQIFKTSQSLSTQGWKYKMQVSMLEIYNESIRDLLSTSRTIAIESVRADSSTSGRQYTITHD 602

  Fly   508 NKNDIYVSNITEETVLDPNHLRHLMHTAKMNRATASTAGNERSSRSHAVTKLELIGRHAEKQEIS 572
            ...:.:||::|...|.....:..|:..|..:|:...|..||:|||||.|..|.:.|.:...::..
plant   603 VNGNTHVSDLTIVDVCSIGQISSLLQQAAQSRSVGKTHMNEQSSRSHFVFTLRISGVNESTEQQV 667

  Fly   573 VGSINLVDLAGSE----SPKTSTRMTETKNINRSLSELTNVILALLQKQDHIPYRNSKLTHLLMP 633
            .|.:||:||||||    |..|..|:.||:.||:|||.|::||.||.:|:||:|:||||||:||.|
plant   668 QGVLNLIDLAGSERLSRSGATGDRLKETQAINKSLSALSDVIFALAKKEDHVPFRNSKLTYLLQP 732

  Fly   634 SLGGNSKTLMFINVSPFQDCFQESVKSLRFAASVNSC------KMTKAK 676
            .|||:||||||:|:||......||:.||||||.||:|      :.|.||
plant   733 CLGGDSKTLMFVNISPDPSSTGESLCSLRFAARVNACEIGIPRRQTSAK 781

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ncd	NP_001287592.1	KISc_C_terminal	346..672	CDD:276817	151/353 (43%)
ncd	NP_001287592.1	KISc	348..678	CDD:214526	153/357 (43%)
ATK5	NP_192428.2	DUF4795	<106..211	CDD:292662
		COG1340	150..414	CDD:224259	36/197 (18%)
		KISc_C_terminal	426..771	CDD:276817	151/347 (44%)
		KISc	428..772	CDD:214526	150/346 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	248	1.000	Domainoid score	I532
eggNOG	1	0.900	-	-		E2759_KOG0239
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H83229
Inparanoid	1	1.050	302	1.000	Inparanoid score	I778
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D364605at2759
OrthoFinder	1	1.000	-	-		FOG0000325
OrthoInspector	1	1.000	-	-		otm2680
orthoMCL	1	0.900	-	-		OOG6_101893
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1242
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.730