Protein Alignment ncd and KIF21A

DIOPT Version :9

• Sequence 1: NP_001287592.1
• Gene: ncd / 43517
• FlyBaseID: FBgn0002924
• Length: 700
• Species: Drosophila melanogaster
• Sequence 2: NP_001365368.1
• Gene: KIF21A / 55605
• HGNCID: 19349
• Length: 1675
• Species: Homo sapiens
• Alignment Length: 400
• Identity: 138/400 - (34%)
• Similarity: 191/400 - (47%)
• Gaps: 75/400 - (18%)

  Fly   348 NIRVFCRIRPPLESEENRMC--CTWTYHDESTVELQSIDAQAKSKMGQQIFSFDQVFHPLSSQSD 410
            ::||..||||.|..|:...|  ||.....|..|.|      .|.|    .|:||.||...|.|..
Human     9 SVRVAVRIRPQLAKEKIEGCHICTSVTPGEPQVFL------GKDK----AFTFDYVFDIDSQQEQ 63

  Fly   411 IF-EMVSPLIQSALDGYNICIFAYGQTGSGKTYTM------DGVPESVGVIPRTVDLLFDSIRGY 468
            |: :.:..||:...:|||..:|||||||:||||||      :.|.|.:|:|.|.|..||.||...
Human    64 IYIQCIEKLIEGCFEGYNATVFAYGQTGAGKTYTMGTGFDVNIVEEELGIISRAVKHLFKSIEEK 128

  Fly   469 RNLGW-------EYEIKATFLEIYNEVLYDL------LSNEQKDMEIRMAKNNKNDIYVSNITEE 520
            :::..       ::::.|.|||:|||.:.||      :..:.|...||:.:::...||...:|..
Human   129 KHIAIKNGLPAPDFKVNAQFLELYNEEVLDLFDTTRDIDAKSKKSNIRIHEDSTGGIYTVGVTTR 193

  Fly   521 TVLDPNHLRHLMHTAKMNRATASTAGNERSSRSHAV-------------------TKLELIGRHA 566
            ||...:.:...:....::|.||||..|.:||||||:                   |..::|...|
Human   194 TVNTESEMMQCLKLGALSRTTASTQMNVQSSRSHAIFTIHVCQTRVCPQIDADNATDNKIISESA 258

  Fly   567 EKQEIS--VGSINLVDLAGSESPK----TSTRMTETKNINRSLSELTNVILALLQKQ---DHIPY 622
            :..|..  ....:.|||||||..|    |..|..|..:||..|..|.|||.||..|.   .|:||
Human   259 QMNEFETLTAKFHFVDLAGSERLKRTGATGERAKEGISINCGLLALGNVISALGDKSKRATHVPY 323

  Fly   623 RNSKLTHLLMPSLGGNSKTLMFINVSPFQDCFQESVKSLRFAASVNSCKMTKAKRNRYLNNSVA- 686
            |:||||.||..||||||:|:|...|||....|.|::.:|::           |.|.|.:.|.|.
Human   324 RDSKLTRLLQDSLGGNSQTIMIACVSPSDRDFMETLNTLKY-----------ANRARNIKNKVMV 377

  Fly   687 ---NSSTQSN 693
               .:|.|.|
Human   378 NQDRASQQIN 387

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ncd	NP_001287592.1	KISc_C_terminal	346..672	CDD:276817	130/373 (35%)
		KISc	348..678	CDD:214526	131/379 (35%)
KIF21A	NP_001365368.1	KISc_KIF4	8..372	CDD:276823	133/383 (35%)
		Cast	<364..836	CDD:401982	7/34 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	556..641
		Smc	<644..1004	CDD:224117
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	779..804
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	841..881
		Rcc_KIF21A	936..1017	CDD:410204
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1116..1138
		Interaction with KANK1 and KANK2. /evidence=ECO:0000269|PubMed:29183992	1146..1167
		WD40	1340..1653	CDD:238121
		WD 1	1346..1383
		WD 2	1386..1424
		WD40 repeat	1391..1450	CDD:293791
		WD 3	1450..1488
		WD40 repeat	1456..1491	CDD:293791
		WD 4	1491..1533
		WD40 repeat	1496..1540	CDD:293791
		WD 5	1542..1579
		WD40 repeat	1548..1581	CDD:293791
		WD 6	1583..1622
		WD40 repeat	1588..1624	CDD:293791
		WD 7	1625..1662

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910