DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ncd and kif11

DIOPT Version :9

Sequence 1:	NP_001287592.1	Gene:	ncd / 43517	FlyBaseID:	FBgn0002924	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	NP_001016116.2	Gene:	kif11 / 548870	XenbaseID:	XB-GENE-978999	Length:	1067	Species:	Xenopus tropicalis

Alignment Length:	372	Identity:	130/372 - (34%)
Similarity:	193/372 - (51%)	Gaps:	58/372 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   348 NIRVFCRIRPPLESEENRMCCTWTYHDESTVELQSIDAQAK----------SKMGQQIFSFDQVF 402
            ||:|..|.||..:.|..          .|:..:...||..|          .|:|::.::||.||
Frog    18 NIQVVVRCRPFNQLERK----------ASSHSVLECDAPRKEVCVRTGGINDKLGKKTYTFDMVF 72

  Fly   403 HPLSSQSDIF-EMVSPLIQSALDGYNICIFAYGQTGSGKTYTMDGVPES-----------VGVIP 455
            .|.:.|.|:: .:|.|::...:.|||..:|||||||:|||:||:|...:           .|:||
Frog    73 GPAAKQIDVYRSVVCPILDEVIMGYNCTVFAYGQTGTGKTFTMEGERSADEEFTWEQDPLAGIIP 137

  Fly   456 RTVDLLFDSIRGYRNLGWEYEIKATFLEIYNEVLYDLLSNEQKDMEIRMA----KNNKNDIYVSN 516
            ||:..:|:.:   ...|.|:.:|.:.||||||.|:|||| ...|:..|:.    ..||..:.:..
Frog   138 RTLHQIFEKL---SENGTEFSVKVSLLEIYNEELFDLLS-PSPDVGERLQMFDDPRNKRGVIIKG 198

  Fly   517 ITEETVLDPNHLRHLMHTAKMNRATASTAGNERSSRSHAVTKLELIGRHAE------KQEISVGS 575
            :.|.:|.:.:.:.|::......|.||||..|..|||||:|..:.:   |.:      ::.:.:|.
Frog   199 LEEVSVHNKDEVYHILERGAARRKTASTLMNAYSSRSHSVFSVTI---HMKETTVDGEELVKIGK 260

  Fly   576 INLVDLAGSE----SPKTSTRMTETKNINRSLSELTNVILALLQKQDHIPYRNSKLTHLLMPSLG 636
            :|||||||||    |.....|..|..|||:||..|..||.||:::..|||||.||||.:|..|||
Frog   261 LNLVDLAGSENIGRSGAVDKRAREAGNINQSLLTLGRVITALVERAPHIPYRESKLTRILQDSLG 325

  Fly   637 GNSKTLMFINVSPFQDCFQESVKSLRFAASVNSCK--MTKAKRNRYL 681
            |.:||.:...|||.....:|:|.:|.:|   |..|  |.|.:.|:.|
Frog   326 GRTKTSIIATVSPASINLEETVSTLEYA---NRAKNIMNKPEVNQKL 369

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ncd	NP_001287592.1	KISc_C_terminal	346..672	CDD:276817	126/361 (35%)
ncd	NP_001287592.1	KISc	348..678	CDD:214526	128/367 (35%)
kif11	NP_001016116.2	KISc_BimC_Eg5	16..368	CDD:276815	129/369 (35%)
		KISc	18..366	CDD:214526	128/367 (35%)
		DUF342	<325..446	CDD:302792	17/48 (35%)
		Microtub_bind	927..1066	CDD:290642
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1048..1067
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910