DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ncd and Klp61F

DIOPT Version :9

Sequence 1:	NP_001287592.1	Gene:	ncd / 43517	FlyBaseID:	FBgn0002924	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	NP_476818.1	Gene:	Klp61F / 38135	FlyBaseID:	FBgn0004378	Length:	1066	Species:	Drosophila melanogaster

Alignment Length:	385	Identity:	135/385 - (35%)
Similarity:	198/385 - (51%)	Gaps:	70/385 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   343 MDLRG-------------NIRVFCRIRPPLESEENRMCCTWTYH------DESTVELQSIDAQAK 388
            ||:.|             ||:|:.|:| ||.|.|.   |..:..      ....|...::|::..
  Fly     1 MDISGGNTSRQPQKKSNQNIQVYVRVR-PLNSRER---CIRSAEVVDVVGPREVVTRHTLDSKLT 61

  Fly   389 SKMGQQIFSFDQVFHPLSSQSDIFE-MVSPLIQSALDGYNICIFAYGQTGSGKTYTMDG------ 446
            .|     |:||:.|.|.|.|.|::. :|||||:..|:|||..:|||||||:|||:||.|
  Fly    62 KK-----FTFDRSFGPESKQCDVYSVVVSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVGNETAEL 121

  Fly   447 -----VPESVGVIPRTVDLLFDSIRGYRNLGWEYEIKATFLEIYNEVLYDLLSNEQKDMEIRMAK 506
                 ....:|:|||.:..|||.:   |.:..||.::.::||:|||.|.||||.:. ..:||:..
  Fly   122 KSSWEDDSDIGIIPRALSHLFDEL---RMMEVEYTMRISYLELYNEELCDLLSTDD-TTKIRIFD 182

  Fly   507 NN--KNDIYVSNITEETVLDPNHLRHLMHTAKMNRATASTAGNERSSRSHAVTKLELIGRHAEKQ 569
            ::  |..:.:..:.|..|...:.:..|:...|..|.||:|..|.:|||||.|..:.:   |..:.
  Fly   183 DSTKKGSVIIQGLEEIPVHSKDDVYKLLEKGKERRKTATTLMNAQSSRSHTVFSIVV---HIREN 244

  Fly   570 EI------SVGSINLVDLAGSES-----PKTSTRMTETKNINRSLSELTNVILALLQKQDHIPYR 623
            .|      .:|.:|||||||||:     .:...|:.||.|||:||..|..||.||:.:..|:|||
  Fly   245 GIEGEDMLKIGKLNLVDLAGSENVSKAGNEKGIRVRETVNINQSLLTLGRVITALVDRAPHVPYR 309

  Fly   624 NSKLTHLLMPSLGGNSKTLMFINVSPFQDCFQESVKSLRFA---------ASVNSCKMTK 674
            .||||.||..||||.:||.:...:||.....:|::.:|.:|         ..||. |:||
  Fly   310 ESKLTRLLQESLGGRTKTSIIATISPGHKDIEETLSTLEYAHRAKNIQNKPEVNQ-KLTK 368

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ncd	NP_001287592.1	KISc_C_terminal	346..672	CDD:276817	130/378 (34%)
ncd	NP_001287592.1	KISc	348..678	CDD:214526	132/367 (36%)
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	129/364 (35%)
		Kinesin	25..356	CDD:278646	124/346 (36%)
		Microtub_bind	923..>1009	CDD:290642
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437905
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840