DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ncd and CG5004

DIOPT Version :9

Sequence 1:	NP_001287592.1	Gene:	ncd / 43517	FlyBaseID:	FBgn0002924	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	NP_573195.1	Gene:	CG5004 / 32698	FlyBaseID:	FBgn0260748	Length:	1247	Species:	Drosophila melanogaster

Alignment Length:	816	Identity:	171/816 - (20%)
Similarity:	291/816 - (35%)	Gaps:	199/816 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 QMPIKT--VLPTDRIRAGLGGGAAGAGAFNVNANQTYCG----NLLPPLSRDLNNLPQVLERRGG 73
            |..|||  .||.|:.::.....|..|.:.|::...:..|    .||.|...::|....|....|.
  Fly   338 QNRIKTNGSLPRDKNKSPFPQQAGVASSANISLLSSSSGYENVRLLGPNRVEINGQIHVPASAGD 402

  Fly    74 GARAASPEPMKLGHRAKLRRSRSACDINE--LRGNKRTAAAPSLP-----SIPSKVSRLGG--AL 129
            |..::......|...|.:|.|....:.|.  ..|.|....:|...     ..|.|....|.  ||
  Fly   403 GGSSSGVSSNALAPTAAVRASHENLNQNHSATTGGKYVPQSPRTKIRTNCMSPKKDVSFGNAFAL 467

  Fly   130 TVSSQRLVRPAAPSSITAT-------AVKRPPVT--RPAP---------------------RAAG 164
            .:|..    |.|.|::.:|       ::.:||:.  .|||                     |...
  Fly   468 AISPP----PLASSAVVSTSKPIPIPSMVKPPLAPKPPAPNQQRDYEQLFKSFERKQQQLDRMVP 528

  Fly   165 GAAAKK------------PAGTGAAASSGAAAAAPKRIAPYDFKARFHDLLEKHKVLKTK----- 212
            ...:.|            .:.|.:...|...|.||:.|.....:.|  :|:::.|.||.:
  Fly   529 AKRSNKNINNLTLNLQSVESQTQSPKPSRKPAPAPRSIHLEQRQRR--ELIQRRKQLKRELAELP 591

  Fly   213 ----YEKQTEDMGELESMPQ-----QLEETQNKLIETESSLKNTQSDNECLQRQVKQHTAKIETI 268
                .|.....:||....|.     ||:..||::...|:....|:...|..|.::||   .||..
  Fly   592 PSAGIEGLELKLGEQPLAPSASPRLQLQALQNRVCRLEAQRNATRVMEENQQAKLKQ---SIEIK 653

  Fly   269 TSTLGRTKEEL----------SELQAIHEKVKTEHAAL-STEVVHLRQRTE-----ELLRCNEQQ 317
            ...|.:.:..|          .|||.:.|.::::.... ..|..:..:.:|     |..:..||:
  Fly   654 QDQLKKLRAMLKQKPNNACLKEELQLVCESLESDRKTFEDLEFQYFEEESEHHASHEEFKRQEQR 718

  Fly   318 ---AAELETCKEQLFQSNME----------RKELHNTVM--DLRGNIRVFCRIRPPLESEENRMC 367
               .|||...:.|:.....|          ...|.|.||  .|.|:..:.|   |...::|:.|.
  Fly   719 LMLEAELAALRIQIGPDEEEPGSPTSPGSTGSNLVNGVMSQSLFGSAELLC---PKRRNQEDLMS 780

  Fly   368 CTWTYHDESTVELQSIDAQAKS--KMGQQIF------SFDQVFHPLSSQSDIFEMVSPL---IQS 421
            .:   .:|:......|:|...:  ::..|:|      |.:|:...||.|.|.|| |:||   :.|
  Fly   781 KS---VNENMFYNHKIEANTSTPKRLPLQLFEDLAGGSCEQISFNLSLQGDRFE-VNPLERRVPS 841

  Fly   422 ALDGYNICIFAYGQTGSGKTYTMDGVPESVGVIPRTVDLLFDSIRGYRNLGWE----YEIKATFL 482
            ..|....|..|.....|........:.:|:..|.|...||. :.:|::.:..|    |::|.
  Fly   842 QDDIDRSCKVANDAPISASQGASTKIFDSIMEIERNRKLLL-AQQGHQVIEHERQKMYDLKK--- 902

  Fly   483 EIYNEVLYDLLSNEQKDME-IRMAKNNKNDIYVSNITEETVLDPNHLRHLMHTAKMNRATASTAG 546
            :.::|.....|.:.|:.|| .|..:::.|....:.:.|:|.|.           |:|:.......
  Fly   903 KSHDEARTQYLLSTQQSMEQQRQLESDANGGKDAKLFEKTELQ-----------KLNQKPGEPVD 956

  Fly   547 NERSSRSHAVTKLELIGRHAEKQEISVGSINLVDLAGSESPKTSTRMTETKNINRSLSELTNVIL 611
            ::       |.|:.....:..:...|.||          ||.|:|..|.......
  Fly   957 DQ-------VQKIAGDKENNVQNRKSTGS----------SPTTTTTTTTGGGTTP---------- 994

  Fly   612 ALLQKQDHIPYRNSKLTHLLMPSLG---------GNSKTLMFINVSPFQD---CFQESVKSLRFA 664
               |:|.|   ...:|.|..: :||         |.:..::..:..|..:   | ..::::.:||
  Fly   995 ---QQQRH---SQPELEHHAI-ALGIGGGGSGGAGGANQMVARSPRPLSEANNC-DATIEAPKFA 1051

  Fly   665 ASV-NSCKMTKAKRNRYLNNS--VANSSTQSNNSGS 697
            ..: :|.....|...|..:||  .|::.:.|.||||
  Fly  1052 NGMDSSASPAVADNKRASSNSQDTASAGSGSGNSGS 1087

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ncd	NP_001287592.1	KISc_C_terminal	346..672	CDD:276817	70/354 (20%)
ncd	NP_001287592.1	KISc	348..678	CDD:214526	70/358 (20%)
CG5004	NP_573195.1	FHA	41..104	CDD:278899
		PH-like	1142..1242	CDD:302622
		PH	1143..1237	CDD:278594
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437947
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930