DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ncd and Kifc2

DIOPT Version :9

Sequence 1:	NP_001287592.1	Gene:	ncd / 43517	FlyBaseID:	FBgn0002924	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	NP_942047.2	Gene:	Kifc2 / 300053	RGDID:	735021	Length:	791	Species:	Rattus norvegicus

Alignment Length:	792	Identity:	197/792 - (24%)
Similarity:	330/792 - (41%)	Gaps:	209/792 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 LERRGGGARAASP--EP-MKLGHRAKLRR--------------SRSACDINE--LRGNKRTAAAP 113
            |.||.|||.|.|.  :| .|.|.:.:.||              |.:.|..:|  .:|.:..||..
  Rat    15 LFRRDGGAAAVSDPGDPTQKSGGQPRGRRRPDQFTSELWTELNSLAGCSESEDGQKGAEGGAAEV 79

  Fly   114 SL------------------------PSI--PSKVSRLGGALTVSSQRLVRPA---APSSITATA 149
            ||                        |.:  |.:|..|   |||:||.|...|   :|....|..
  Rat    80 SLEEALMRLAEFLSVQLGAEESCGTTPDLGKPGEVPPL---LTVTSQLLALLAWTRSPRGRQALL 141

  Fly   150 VKRPPVTRPAPRAAGGAAAKKPAGTGAAASSGAAAAAPKRIAPYDFKARFHDLLEKHKVLKTKYE 214
            ....|.....|....|:.:::.    ::.|:......|:            |..::|:..:.:.|
  Rat   142 QGTQPTCPVQPSTLDGSLSQEE----SSQSTPILDEVPR------------DETQEHQPPQLEEE 190

  Fly   215 KQTED------MGELESMPQQLEETQNK------------------------------------- 236
            ::...      :|:||.:.||||:.:.:
  Rat   191 QRVWQRLEQLILGQLEELRQQLEQQEEELSRLRLGVGVTDSEKRVQHLTLENEALKQSLSLTRDL 255

  Fly   237 -------------------LIETESSLKNTQSDNECLQRQVKQHTAKIETITSTLGRTKEEL--- 279
                               |:|.:..|:..|...|.|:.|:.....:::.:...|.:.::|.
  Rat   256 LLHWVPGPLTRPPQEEAGALLELQGQLQEAQDTTEALRVQLGVQELQLQGLRGALQQLQQETEQN 320

  Fly   280 --SELQAIHEKVKTEHAALSTEVVHLRQRTEELLRCNEQQ---AAELETCKEQLFQ--------- 330
              .|||.:|.::    |.|...:..|||      .|.:.:   :...::|:..|.:
  Rat   321 CRQELQQVHGQL----AGLRARMASLRQ------GCGDLRGLVSTFTQSCQGSLSEAQGQVSWAL 375

  Fly   331 -------SNMERKELHNT--------VMDLRGNIRVFCRIRPPLESEENRMCCTWTYHDESTVEL 380
                   :..:..|.|..        :::|:|||||.||:||    .|.:        ..|.|.:
  Rat   376 GALSAGKAKTQLPEGHQAPPTGCSGRLLELKGNIRVLCRLRP----AEGK--------PSSLVSV 428

  Fly   381 Q-----SIDAQAKSKMGQQIFSFDQVFHPLSSQSDIFEMVSPLIQSALDGYNICIFAYGQTGSGK 440
            :     ||....:.:  |..|..|.||...:||.::|..:.|.:.|.|.||::|:|.|||||:||
  Rat   429 EPGQGGSITTCYRGR--QHRFRLDWVFPQDASQEEVFRQLEPAVLSCLQGYSVCVFTYGQTGTGK 491

  Fly   441 TYTMDGVPESVGVIPRTVDLLFDSIRGYRNLGWEYEIKATFLEIYNEVLYDLLSNEQKD-MEIRM 504
            ||:|:|.||..|:.||.:.|||..:    ..|..:.:..:.:|||||.:.|||:....: :.:|.
  Rat   492 TYSMEGPPEDPGIAPRALQLLFREM----GTGGHHHVTLSMVEIYNEAVRDLLATGPPERLVVRQ 552

  Fly   505 AKNNKNDIYVSNITEETVLDPNHLRHLMHTAKMNRATASTAGNERSSRSHAVTKLELIGRHAEKQ 569
            ....:..|.|:.:|...|.:...|..::...:.|||||:|..|:.||||||:..|.|......:.
  Rat   553 GPAGQGGIQVAGLTHWDVPNLETLHQMLSLGRSNRATAATVMNQHSSRSHALITLTLRAASPPRA 617

  Fly   570 EISVGSINLVDLAGSE-------------SPKTSTRMTETKNINRSLSELTNVILALLQKQDHIP 621
            :...|:::||||||||             .|..:.|:.|.:.|||||..|..|:.||..::.|:|
  Rat   618 QGITGTLHLVDLAGSERVWKAGVASPVQRDPNGARRLREAQAINRSLLALGGVMAALRARRPHVP 682

  Fly   622 YRNSKLTHLLMPSLGGNSKTLMFINVSPFQDCFQESVKSLRFAASVNSCKMTKAKRNRYLNNSVA 686
            :|:|:||.||.|:||..:..::.:.:|...:...|::.||:||..|...::..|:|.|...:...
  Rat   683 FRDSQLTRLLQPALGEGTTAVLLLQISTRAEDLGETICSLKFAQRVGQVELGPARRRRTPRSGTP 747

  Fly   687 NS-STQSNNSGS 697
            :| ||.:..:|:
  Rat   748 SSLSTDTPLTGT 759

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ncd	NP_001287592.1	KISc_C_terminal	346..672	CDD:276817	117/344 (34%)
ncd	NP_001287592.1	KISc	348..678	CDD:214526	117/348 (34%)
Kifc2	NP_942047.2	KISc_C_terminal	406..733	CDD:276817	117/344 (34%)
Kifc2	NP_942047.2	KISc	408..737	CDD:214526	116/346 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D181609at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920