DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ncd and pkl1

DIOPT Version :9

Sequence 1:	NP_001287592.1	Gene:	ncd / 43517	FlyBaseID:	FBgn0002924	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	NP_594189.1	Gene:	pkl1 / 2542655	PomBaseID:	SPAC3A11.14c	Length:	832	Species:	Schizosaccharomyces pombe

Alignment Length:	541	Identity:	204/541 - (37%)
Similarity:	295/541 - (54%)	Gaps:	91/541 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   195 FKARFHDLLEKHKVLKTKYEKQTEDMGELESMPQQLEETQNKL----IETESSLKNTQSDNECLQ 255
            ||.:..||||.         ||.|:...:..:..:.:.|..||    .|.|.::|..:|:....:
pombe   320 FKEKILDLLEM---------KQQEENDRISHIEYENDLTVKKLKRRISELEMAVKEYESEKSYSE 375

  Fly   256 RQVKQHTAKIETITSTLGRTKEELSELQAIHEK-VKTEHAALSTEVVHLRQRTEELL-------- 311
               |::..||.::...|   :::|:|:..:..| :|.||...||.     ::.|||.
pombe   376 ---KEYEEKISSLRIEL---EDKLAEIDMLRNKLLKEEHKHHSTS-----EKLEELSKYVASIQD 429

  Fly   312 --RCNEQQAAELETCKEQLFQSNME-----------RKELHNTVMDLRGNIRVFCRIRPPLESEE 363
              |.|.|.|.||:...:||.:.|.:           |::|||.:.:|:||||||||:||.|.|||
pombe   430 KERNNGQNALELQARIQQLERRNEDMYNKLLAEEIIRRKLHNDIQELKGNIRVFCRVRPLLPSEE 494

  Fly   364 NRMCC--TWTYHDESTVELQSI---DAQAKSKMGQQI-----FSFDQVFHPLSSQSDIFEMVSPL 418
            :..|.  ...:.|:..:|.|.:   ....:|.:|...     ||||:||.|.|..|.:||.:|.|
pombe   495 SEYCIADVLQFPDKDALEPQKLILKGPNVESSLGHTYDRNYEFSFDRVFAPESDNSSVFEEISQL 559

  Fly   419 IQSALDGYNICIFAYGQTGSGKTYTMDGVPESVGVIPRTVDLLFDSIRGYRNLGWEYEIKATFLE 483
            ||||:||||:.|||||||||||||||.   ...|:|..::..:|:.:...|..||.|:::..|||
pombe   560 IQSAIDGYNVSIFAYGQTGSGKTYTMS---SQDGMIAMSIKHIFNYLSTLREKGWVYKLRGQFLE 621

  Fly   484 IYNEVLYDLLSNEQKDMEIRMAKNNKNDIY---------VSNITEETVLDPNH---LRHLMHTAK 536
            ||||.:||||:..:      |.||.|:||:         |.|:   :::|.|.   :..:::.|.
pombe   622 IYNETIYDLLNKAE------MLKNPKHDIHHDEKERRTTVDNV---SIIDFNEEDTVYKMLNRAG 677

  Fly   537 MNRATASTAGNERSSRSHAVTKLELIGRHAEKQEISVGSINLVDLAGSE----SPKTSTRMTETK 597
            .||..|:|..||||||||.|..|.:.|.::..::|..|::|||||||||    |.....|:.||:
pombe   678 ENRFIAATKANERSSRSHTVFMLYIDGENSRTKQICKGTLNLVDLAGSERLSYSQAVGDRLRETQ 742

  Fly   598 NINRSLSELTNVILAL-------LQKQDHIPYRNSKLTHLLMPSLGGNSKTLMFINVSPFQDCFQ 655
            .||:|||.|.:||.||       .:::.||||||||||:||..|||..:|||||:||||.:..|.
pombe   743 AINKSLSCLGDVIHALGNASNSTTKEKSHIPYRNSKLTYLLKYSLGKGAKTLMFVNVSPLKSQFM 807

  Fly   656 ESVKSLRFAASVNSCKMTKAK 676
            :::.|||||..||..|:...|
pombe   808 DTLNSLRFATKVNDTKVGSIK 828

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ncd	NP_001287592.1	KISc_C_terminal	346..672	CDD:276817	157/358 (44%)
ncd	NP_001287592.1	KISc	348..678	CDD:214526	158/362 (44%)
pkl1	NP_594189.1	Microtub_bd	458..>486	CDD:293401	12/27 (44%)
		KISc_C_terminal	477..823	CDD:276817	157/357 (44%)
		KISc	479..829	CDD:214526	158/362 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	240	1.000	Domainoid score	I453
eggNOG	1	0.900	-	-		E2759_KOG0239
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	296	1.000	Inparanoid score	I618
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000325
OrthoInspector	1	1.000	-	-		otm47329
orthoMCL	1	0.900	-	-		OOG6_101893
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1242
TreeFam	1	0.960	-	-
	10	9.720