DRSC/TRiP Functional Genomics Resources

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Protein Alignment ncd and KIF4A

DIOPT Version :9

Sequence 1:NP_001287592.1 Gene:ncd / 43517 FlyBaseID:FBgn0002924 Length:700 Species:Drosophila melanogaster
Sequence 2:NP_036442.3 Gene:KIF4A / 24137 HGNCID:13339 Length:1232 Species:Homo sapiens


Alignment Length:362 Identity:139/362 - (38%)
Similarity:191/362 - (52%) Gaps:41/362 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly   349 IRVFCRIRP--PLE-SEENRMCCTWTYHDESTVELQSIDAQAKSKMGQQIFSFDQVFHPLSSQSD 410
            :||..|.||  |.| ||..:||.::.     ..|.|.:....||      |::|.||.|.:.|.:
Human    10 VRVALRCRPLVPKEISEGCQMCLSFV-----PGEPQVVVGTDKS------FTYDFVFDPSTEQEE 63

  Fly   411 IFE-MVSPLIQSALDGYNICIFAYGQTGSGKTYTMDGV-------PESVGVIPRTVDLLFDSIRG 467
            :|. .|:|||:....|||..:.|||||||||||:|.|.       ..:||||||.:.|||..|. 
Human    64 VFNTAVAPLIKGVFKGYNATVLAYGQTGSGKTYSMGGAYTAEQENEPTVGVIPRVIQLLFKEID- 127

  Fly   468 YRNLGWEYEIKATFLEIYNEVLYDLLSNEQKDMEIRMAKNNKNDIYVSNITEETVLDPNHLRHLM 532
             :...:|:.:|.::||||||.:.|||...::..:|.:.::.|..|.:..:||:|||........:
Human   128 -KKSDFEFTLKVSYLEIYNEEILDLLCPSREKAQINIREDPKEGIKIVGLTEKTVLVALDTVSCL 191

  Fly   533 HTAKMNRATASTAGNERSSRSHAVTKLELIGRHAEKQEISVGS-INLVDLAGSESPKTS----TR 592
            .....:|..||||.|.:||||||:..:.|..|....:..|..| ::||||||||..|.:    .|
Human   192 EQGNNSRTVASTAMNSQSSRSHAIFTISLEQRKKSDKNSSFRSKLHLVDLAGSERQKKTKAEGDR 256

  Fly   593 MTETKNINRSLSELTNVILAL--LQKQDHIPYRNSKLTHLLMPSLGGNSKTLMFINVSPFQDCFQ 655
            :.|..||||.|..|.|||.||  .:|...:|||:||||.||..||||||.|||...|||.....:
Human   257 LKEGININRGLLCLGNVISALGDDKKGGFVPYRDSKLTRLLQDSLGGNSHTLMIACVSPADSNLE 321

  Fly   656 ESVKSLRFAASVNSCKMTKAKRNRYLNNSVANSSTQS 692
            |::.:||:|......|          |..:.|...|:
Human   322 ETLNTLRYADRARKIK----------NKPIVNIDPQT 348

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ncdNP_001287592.1 KISc_C_terminal 346..672 CDD:276817 135/340 (40%)
KISc 348..678 CDD:214526 136/346 (39%)
KIF4ANP_036442.3 KISc_KIF4 8..337 CDD:276823 135/339 (40%)
SMC_prok_B <375..714 CDD:274008
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 496..515
Smc 558..>918 CDD:224117
Required for the interaction with PRC1. /evidence=ECO:0000269|PubMed:15297875 663..1232
Nuclear localization signal. /evidence=ECO:0000269|PubMed:11736643 793..798
Globular 1000..1232
Pre-SET <1078..1120 CDD:368254
CRD, required for [4Fe-4S] cluster binding and localization to the spindle midzone and midbody during anaphase and telophase. /evidence=ECO:0000269|PubMed:29848660 1086..1144
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1122..1142
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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