DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ncd and Kif15

DIOPT Version :9

Sequence 1:	NP_001287592.1	Gene:	ncd / 43517	FlyBaseID:	FBgn0002924	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	NP_034750.1	Gene:	Kif15 / 209737	MGIID:	1098258	Length:	1387	Species:	Mus musculus

Alignment Length:	399	Identity:	146/399 - (36%)
Similarity:	202/399 - (50%)	Gaps:	52/399 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   324 CKEQLFQSNMERKELHNTVMDLRGN-IRVFCRIRPPLESE-----ENRMCCTWTYHDESTVELQS 382
            ||.:|  .|:...  |:......|: |:||.||||..|..     |...|.  :...::|:.|.
Mouse     5 CKSEL--RNVTNS--HSNQPSNEGDAIKVFVRIRPAEEGARSADGEQSFCL--SVLSQTTLRLH- 62

  Fly   383 IDAQAKSKMGQQIFSFDQVFHPLSSQSDIFEMVS-PLIQSALDGYNICIFAYGQTGSGKTYTMDG 446
                  |....:.|.||.|....::|..:|..|: .:::|.:.|||..||||||||||||:||.|
Mouse    63 ------SNPDPKTFVFDYVAGMDTTQESVFSTVAKSIVESCMSGYNGTIFAYGQTGSGKTFTMMG 121

  Fly   447 VPES-------VGVIPRTVDLLF---DSIRGYRNLGWEYEIKATFLEIYNEVLYDLLSNEQKDME 501
            ..:|       .|:|||:.:.||   |..:.....|..:..|.:|:|:|||.:||||.:....:.
Mouse   122 PSDSDNFSHNLRGIIPRSFEYLFSLIDREKEKAGAGKSFLCKCSFIEVYNEQIYDLLDSASVGLY 186

  Fly   502 IRMAKNNKNDIYVSNITEETVLDPNHLRHLMHTAKMNRATASTAGNERSSRSHAV--TKLELIGR 564
            :|  ::.|..::|....|:.|........::.....||..|||:.|..|||||||  ..:|.:.:
Mouse   187 LR--EHIKKGVFVVGAVEQAVTSAAETYQVLSRGWRNRRVASTSMNRESSRSHAVFTITIESMEK 249

  Fly   565 HAEKQEISVGSINLVDLAGSESPKTS----TRMTETKNINRSLSELTNVILALLQ----KQDHIP 621
            .:|...|....:|||||||||..|.:    .|:.|..|||||||.|..||.||:.    ||.||.
Mouse   250 SSETVNIRTSLLNLVDLAGSERQKDTHAEGMRLKEAGNINRSLSCLGQVITALVDVGNGKQRHIC 314

  Fly   622 YRNSKLTHLLMPSLGGNSKTLMFINVSPFQDCFQESVKSLRFAASVNSCKMTKAKRNRYLNNSVA 686
            ||:||||.||..|||||:||.:..||.|...||.|::.:|.||   ...|:.|       |.:|.
Mouse   315 YRDSKLTFLLRDSLGGNAKTAIIANVHPGSRCFGETLSTLNFA---QRAKLIK-------NKAVV 369

  Fly   687 NSSTQSNNS 695
            |..||.|.|
Mouse   370 NEDTQGNVS 378

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ncd	NP_001287592.1	KISc_C_terminal	346..672	CDD:276817	132/352 (38%)
ncd	NP_001287592.1	KISc	348..678	CDD:214526	133/356 (37%)
Kif15	NP_034750.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23		5/21 (24%)
		KISc_KLP2_like	25..373	CDD:276824	136/368 (37%)
		KISc	26..370	CDD:214526	135/364 (37%)
		Kinesin-relat_1	463..551	CDD:289481
		SMC_prok_B	520..1339	CDD:274008
		HMMR_C	1267..>1387	CDD:292530
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833458
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840