DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ncd and Kifc2

DIOPT Version :9

Sequence 1:	NP_001287592.1	Gene:	ncd / 43517	FlyBaseID:	FBgn0002924	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	NP_034760.2	Gene:	Kifc2 / 16581	MGIID:	109187	Length:	792	Species:	Mus musculus

Alignment Length:	776	Identity:	200/776 - (25%)
Similarity:	329/776 - (42%)	Gaps:	176/776 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 LERRGGGARAASP--EP-MKLGHRAKLRR--------------SRSACDINELRGNKRTAAAPSL 115
            |.||.|||.|.|.  :| .|.|.:.:.||              |.:.|..:| .|.|......:.
Mouse    15 LFRRDGGAAAVSDPGDPTQKSGGQPRGRRRPDQFTSELWSELNSLAGCSESE-DGQKGAEGGAAE 78

  Fly   116 PSIPSKVSRLGGALTV---------SSQRLVRPA-APSSITAT-------AVKRPPVTRPA-PRA 162
            .|:...:.||...|:|         ::..|.:|. .|..:|.|       |..|.|..|.| .:.
Mouse    79 VSLEEALMRLAEFLSVQLGAEESCGTTPDLGKPGEVPPLLTVTSQLLALLAWTRSPRGRQALLQG 143

  Fly   163 AGGAAAKKPAGTGAAASSGAAAAAPKRI---APYDFKARFHDLLEKHKVLKTKYEKQTED----- 219
            .......:|:....:.|...:::.|..|   .|       .|..::|:.|:.:.|::...
Mouse   144 TQPTCPVQPSTLDGSLSQEESSSQPTPILDEVP-------RDETQEHQPLQLEEEQRVWQRLEQL 201

  Fly   220 -MGELESMPQQLEETQNK----------------------------------------------- 236
             :|:||.:.||||:.:.:
Mouse   202 ILGQLEELRQQLEQQEEELSRLRLGVGVTDSEKRVQHLTLENEALKQSLSLTRDLLLHWGPGPLP 266

  Fly   237 ---------LIETESSLKNTQSDNECLQRQVKQHTAKIETITSTLGRTKEEL-----SELQAIHE 287
                     |:|.:..|:..|...|.|:.|:.....:::.:...|.:.::|.     .|||.:|.
Mouse   267 RLSQEEAGALLELQGQLQEAQDTTEALRVQLGAQELQLQGLQGALRQLQQETEQNCRQELQQVHG 331

  Fly   288 KVKTEHAALSTEVVHLRQRTEEL--------LRC----NEQQ--------AAELETCKEQLFQSN 332
            ::    |.|...:..|||...:|        ..|    :|.|        |......|.||.:.|
Mouse   332 QL----AGLRARMASLRQGCGDLRGLVSTFTQSCQGSLSEAQGQVSWALGALSAGKAKTQLSEGN 392

  Fly   333 MERKE-LHNTVMDLRGNIRVFCRIRPPLESEENRMCCTWTYHDESTVELQ-----SIDAQAKSKM 391
            ..... ....:::|:|||||.||:| |.|.:.:           |.|.::     :|....:.:
Mouse   393 QAPPTGCSGRLLELKGNIRVLCRLR-PAEGQPS-----------SLVSVEPGQGGTITTCYRGR- 444

  Fly   392 GQQIFSFDQVFHPLSSQSDIFEMVSPLIQSALDGYNICIFAYGQTGSGKTYTMDGVPESVGVIPR 456
             |..|..|.||...:||.::|..:.|.:.|.|.||::|||.|||||:||||:|:|.||..|:.||
Mouse   445 -QHRFRLDWVFPQDASQEEVFRQLEPAVLSCLQGYSVCIFTYGQTGTGKTYSMEGPPEDPGIAPR 508

  Fly   457 TVDLLFDSIRGYRNLGWEYEIKATFLEIYNEVLYDLLSNEQKD-MEIRMAKNNKNDIYVSNITEE 520
            .:.|||..:    ..|..:.:..:.:|||||.:.|||:....: :.:|.....:..|.|:.:|..
Mouse   509 ALQLLFREM----GTGGHHHVTLSMVEIYNEAVRDLLATGPPERLVVRQGPAGQGGIQVAGLTHW 569

  Fly   521 TVLDPNHLRHLMHTAKMNRATASTAGNERSSRSHAVTKLELIGRHAEKQEISVGSINLVDLAGSE 585
            .|.:...|..::...:.|||||:|..|:.||||||:..|.|......:.:...|:::||||||||
Mouse   570 DVPNLETLHQMLSLGRSNRATAATVMNQHSSRSHALVTLTLRAASPPRAQGITGTLHLVDLAGSE 634

  Fly   586 -------------SPKTSTRMTETKNINRSLSELTNVILALLQKQDHIPYRNSKLTHLLMPSLGG 637
                         .|..:.|:.|.:.|||||..|..|:.||..::.|:|:|:|:||.||.|:|..
Mouse   635 RVWKAGVASPVQRDPNGARRLREAQAINRSLLALGGVMAALRARRPHVPFRDSQLTRLLQPALCA 699

  Fly   638 NSKTLMFINVSPFQDCFQESVKSLRFAASVNSCKMTKAKRNRYLNNSVANS-STQSNNSGS 697
            .:..::.:.:|...:...|::.||:||..|...::..|:|.|...:...:| ||.:..:|:
Mouse   700 GTTAVLLLQISTRAEDLGETICSLKFAERVGQVELGPARRRRAPRSGTPSSLSTDTPLTGT 760

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ncd	NP_001287592.1	KISc_C_terminal	346..672	CDD:276817	116/344 (34%)
ncd	NP_001287592.1	KISc	348..678	CDD:214526	116/348 (33%)
Kifc2	NP_034760.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	22..45		8/22 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	142..184		6/48 (13%)
		KISc_C_terminal	407..734	CDD:276817	116/344 (34%)
		KISc	409..735	CDD:214526	115/343 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	734..792		7/27 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0239
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D181609at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820