Protein Alignment ncd and KIF3A

DIOPT Version :10

• Sequence 1: NP_476651.1
• Gene: ncd / 43517
• FlyBaseID: FBgn0002924
• Length: 700
• Species: Drosophila melanogaster
• Sequence 2: NP_001287720.1
• Gene: KIF3A / 11127
• HGNCID: 6319
• Length: 726
• Species: Homo sapiens
• Alignment Length: 350
• Identity: 135/350 - (38%)
• Similarity: 194/350 - (55%)
• Gaps: 30/350 - (8%)

  Fly   348 NIRVFCRIRPPLESEENRMCCTWTYH-DE--STVELQSIDAQAKSKMGQQIFSFDQVFHPLSSQS 409
            |::|..|.| ||...|..||...... ||  .|:.:...|:   |....:.|:||.||.|.|.|.
Human    14 NVKVVVRCR-PLNEREKSMCYKQAVSVDEMRGTITVHKTDS---SNEPPKTFTFDTVFGPESKQL 74

  Fly   410 DIFEMVS-PLIQSALDGYNICIFAYGQTGSGKTYTMDGV---PESVGVIPRTVDLLFDSIRGYRN 470
            |::.:.: |:|.|.|:|||..||||||||:|||:||:||   ||..|:||.:...:|..|.....
Human    75 DVYNLTARPIIDSVLEGYNGTIFAYGQTGTGKTFTMEGVRAIPELRGIIPNSFAHIFGHIAKAEG 139

  Fly   471 LGWEYEIKATFLEIYNEVLYDLLSNEQKDMEIRMAKNNKND--IYVSNITEETVLDPNHLRHLMH 533
             ...:.::.::||||||.:.|||.   ||...|:....:.|  :|:.:::...|.:.:.:..:|.
Human   140 -DTRFLVRVSYLEIYNEEVRDLLG---KDQTQRLEVKERPDVGVYIKDLSAYVVNNADDMDRIMT 200

  Fly   534 TAKMNRATASTAGNERSSRSHAVTKLELIGRHAEK-----QEISVGSINLVDLAGSE----SPKT 589
            ....||:..:|..||.||||||:..:.:  ..:||     ..:.:|.::||||||||    :..|
Human   201 LGHKNRSVGATNMNEHSSRSHAIFTITI--ECSEKGIDGNMHVRMGKLHLVDLAGSERQAKTGAT 263

  Fly   590 STRMTETKNINRSLSELTNVILALLQ-KQDHIPYRNSKLTHLLMPSLGGNSKTLMFINVSPFQDC 653
            ..|:.|...||.|||.|.|||.||:. |..|:||||||||.||..||||||||:|..|:.|....
Human   264 GQRLKEATKINLSLSTLGNVISALVDGKSTHVPYRNSKLTRLLQDSLGGNSKTMMCANIGPADYN 328

  Fly   654 FQESVKSLRFAASVNSCKMTKAKRN 678
            :.|::.:||:|....:.| .||:.|
Human   329 YDETISTLRYANRAKNIK-NKARIN 352

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ncd	NP_476651.1	PRK03918	<204..350	CDD:235175	1/1 (100%)
		KISc_C_terminal	346..672	CDD:276817	131/342 (38%)
KIF3A	NP_001287720.1	KISc_KIF3	13..345	CDD:276822	131/340 (39%)
		Smc	<451..>615	CDD:440809