Protein Alignment ncd and Kifc1

DIOPT Version :10

• Sequence 1: NP_476651.1
• Gene: ncd / 43517
• FlyBaseID: FBgn0002924
• Length: 700
• Species: Drosophila melanogaster
• Sequence 2: NP_001182227.1
• Gene: Kifc1 / 100502766
• MGIID: 109596
• Length: 674
• Species: Mus musculus
• Alignment Length: 680
• Identity: 237/680 - (34%)
• Similarity: 343/680 - (50%)
• Gaps: 114/680 - (16%)

  Fly    70 RRGGGARAASPEPMK-----LGHRAKLRRSRS----ACDINELRGNKRTAAAPSLPSIPSKVSRL 125
            :||......:.||.|     :|...|:..||.    ...:::.:|:......|.... |...|.:
Mouse    38 KRGPDQMEDALEPAKKRTRVMGAVTKVDTSRPRGPLLSTVSQTQGHTAAQKGPKKTG-PRGCSAI 101

  Fly   126 GGALTVSSQRLVRPAAPSSITATAVKRPPVTRPAPRAAGGAAAKKPAGTGAAASSGAAAAAPKRI 190
            |..|  .||:.| ||||:        :.|.|..||...|..|.|:||
Mouse   102 GTVL--RSQKPV-PAAPA--------QKPGTSTAPVVVGKRAGKRPA------------------ 137

  Fly   191 APYDFKARFHDLLEKHKVLKTKYEKQTEDMGELES--MPQQLEETQNKLI-------ETESSLKN 246
              :|.|.:..||.|:.|    :|.::|:.: |||:  :.:||.|.|.:..       ..|..|.:
Mouse   138 --WDLKGQLCDLNEELK----RYREKTQTL-ELENRGLREQLREVQEQATTLGTERNTLEGELAS 195

  Fly   247 TQSDNECLQRQVKQHTAKIETITSTLGRTKEELSELQAIHEKVKTEHAALST------------- 298
            .:|..|..|::::..:|::..:...||..:..|.|||....:::.|.:.|||
Mouse   196 VRSRAEQDQQRLETLSARVLELEECLGTRERLLQELQGERLQLQEERSTLSTQLEEQERRFQATE 260

  Fly   299 --------EVVHLRQRTEELLRCNEQQAAELETCKEQLFQSNMERKELHNTVMDLRGNIRVFCRI 355
                    |||.|||:||..:....:|.       ::|:...|||:.|||.:.:|:||||||||:
Mouse   261 AALSSSQEEVVCLRQKTEAQVTLLAEQG-------DRLYGLEMERRRLHNQLQELKGNIRVFCRV 318

  Fly   356 RPPLESEENRMCCTWTY-------HDEST-VELQSIDAQAKSKMG------QQIFSFDQVFHPLS 406
            ||.||.|.........:       .|..| :.|...|.:..:..|      :..||||:||.|.|
Mouse   319 RPVLEGESTPSPGFLVFPPGPAGPSDPPTGLSLSRSDDRRSTLTGAPAPTVRHDFSFDRVFPPGS 383

  Fly   407 SQSDIFEMVSPLIQSALDGYNICIFAYGQTGSGKTYTMD----GVPESVGVIPRTVDLLFDSIRG 467
            .|.::||.::.|:|||||||.:|||||||||||||:||:    |.|:..|:|||.:..||...:.
Mouse   384 KQEEVFEEIAMLVQSALDGYPVCIFAYGQTGSGKTFTMEGGPRGDPQLEGLIPRAMRHLFSVAQE 448

  Fly   468 YRNLGWEYEIKATFLEIYNEVLYDLLSNEQK-----DMEIRMAKNNKNDIYVSNITEETVLDPNH 527
            ....||.|...|:::|||||.:.|||:...:     :.|||.|.....::.|:|.....|.....
Mouse   449 MSGQGWTYSFVASYVEIYNETVRDLLATGPRKGQGGECEIRRASPGSEELTVTNARYVPVSCEKE 513

  Fly   528 LRHLMHTAKMNRATASTAGNERSSRSHAVTKLELIGRHAEKQEISVGSINLVDLAGSE------- 585
            :..|:|.|..|||.|.||.|:||||||:|.:|::.|.||.:.......:|||||||||
Mouse   514 VEALLHLAHQNRAVAHTAQNKRSSRSHSVFQLQISGEHAARGLQCGAPLNLVDLAGSERLDPGLH 578

  Fly   586 -SPKTSTRMTETKNINRSLSELTNVILALLQKQDHIPYRNSKLTHLLMPSLGGNSKTLMFINVSP 649
             .|....|:.||:.||.|||.|..||:||..|:.|:||||||||:||..||||::|.|||:|:||
Mouse   579 LGPGERDRLRETQAINSSLSTLGLVIMALSNKESHVPYRNSKLTYLLQNSLGGSAKMLMFVNISP 643

  Fly   650 FQDCFQESVKSLRFAASVNSCKMTKAKRNR 679
            .::...||:.|||||:.||.|.:..|:.|:
Mouse   644 LEENVSESLNSLRFASKVNQCVIGTAQANK 673

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ncd	NP_476651.1	PRK03918	<204..350	CDD:235175	46/175 (26%)
		KISc_C_terminal	346..672	CDD:276817	156/356 (44%)
Kifc1	NP_001182227.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	66..96		4/30 (13%)
		SMC_prok_B	<146..308	CDD:274008	45/173 (26%)
		KISc_C_terminal	309..666	CDD:276817	156/356 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	327..366		5/38 (13%)