DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ncd and kif13b

DIOPT Version :9

Sequence 1:	NP_001287592.1	Gene:	ncd / 43517	FlyBaseID:	FBgn0002924	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	XP_031758942.1	Gene:	kif13b / 100492799	XenbaseID:	XB-GENE-956968	Length:	1943	Species:	Xenopus tropicalis

Alignment Length:	377	Identity:	130/377 - (34%)
Similarity:	189/377 - (50%)	Gaps:	60/377 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   349 IRVFCRIRPPLESE-----------ENRMCCTWTYHDESTVELQSIDAQAKSKMGQQIFSFDQVF 402
            ::|..||||....|           ||.....:    .|...|...||:::.|    :|::|..|
Frog     6 VKVAVRIRPMNRREVDLQTKCVVDVENNQIVLY----PSNASLSKGDARSQPK----VFAYDHCF 62

  Fly   403 --------HPLSSQSDIFEMVSP-LIQSALDGYNICIFAYGQTGSGKTYTMDGVPESVGVIPRTV 458
                    ...:.|..:|:.:.. ::|:|.:|||.||||||||||||:|||.|..:..|:|||..
Frog    63 WSMDESVKEKFAGQDVVFQCLGENILQNAFEGYNACIFAYGQTGSGKSYTMMGTADQPGLIPRLC 127

  Fly   459 DLLFDSIRGYRNLGWEYEIKATFLEIYNEVLYDLLSNEQKDMEIRMAKNNKNDIYVSNITEETVL 523
            ..||:..:...|....::::.:|:|||||.:.|||..:.....:::.::.....||..:::..|.
Frog   128 STLFERTQKAENEELSFKVEVSFMEIYNEKVRDLLDPKGSRQSLKVREHKVLGPYVDGLSKLAVT 192

  Fly   524 DPNHLRHLMHTAKMNRATASTAGNERSSRSHAVTKLELI--------GRHAEKQEISVGSINLVD 580
            ....:..||.....:|..|:|..||.|||||||..:.|.        |...||    |..::|||
Frog   193 SYKDIESLMSEGNKSRTVAATNMNEESSRSHAVFNIILTHTLVDVKSGTSGEK----VSKLSLVD 253

  Fly   581 LAGSE-SPKTST---RMTETKNINRSLSELTNVILALL------QKQDHIPYRNSKLTHLLMPSL 635
            ||||| :.||..   |:.|..|||:||:.|..||.||.      .|...:|||:|.||.||..||
Frog   254 LAGSERATKTGAAGERLKEGSNINKSLTTLGLVISALADQGAGKNKNKFVPYRDSVLTWLLKDSL 318

  Fly   636 GGNSKTLMFINVSPFQDCFQESVKSLRFAASVNSCKMTKAKRNRYLNNSVAN 687
            ||||||.|...|||..|.:.|::.:||:|        .:||  ..:|::|.|
Frog   319 GGNSKTAMVATVSPAADNYDETLSTLRYA--------DRAK--NIVNHAVVN 360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ncd	NP_001287592.1	KISc_C_terminal	346..672	CDD:276817	125/360 (35%)
ncd	NP_001287592.1	KISc	348..678	CDD:214526	127/366 (35%)
kif13b	XP_031758942.1	KISc_KIF1A_KIF1B	4..360	CDD:276816	129/375 (34%)
		Kinesin_assoc	357..469	CDD:406567	2/4 (50%)
		FHA	449..544	CDD:238017
		KIF1B	755..801	CDD:403579
		DUF3585	<1097..1141	CDD:419985
		DUF3694	<1185..1277	CDD:403614
		CAP_GLY	1810..1873	CDD:396049
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910