DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ncd and setx

DIOPT Version :9

Sequence 1:	NP_001287592.1	Gene:	ncd / 43517	FlyBaseID:	FBgn0002924	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	XP_002936221.1	Gene:	setx / 100145435	XenbaseID:	XB-GENE-966858	Length:	2535	Species:	Xenopus tropicalis

Alignment Length:	761	Identity:	145/761 - (19%)
Similarity:	241/761 - (31%)	Gaps:	236/761 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 QTYCGNLLPPLSRDL--------NNLPQVLERRGGGARAASPEPMKLGHRAKLRRSRSACDINEL 103
            :|....|...||:.|        |:||:...|.....::.:||
Frog   707 KTNLSELKSKLSKVLKKSSFKRQNSLPENTNRMDEDKKSVAPE---------------------- 749

  Fly   104 RGNKRTAAAPSLPSIP-------------SKVSRLGGALTVSSQRLVRPAAPSSITATAVKRPPV 155
            ..|....|...:.|.|             |..|....|:|...|||........:...:||..|:
Frog   750 SNNTFLPATTYIKSEPHDPLFKQPSCNGNSSCSSDNVAVTKQLQRLSIENRVPEVQTVSVKNEPL 814

  Fly   156 TRPAPRAAGG---------AAAKKPAGTGAAASSGAAAAAPKRIAPYD------FKARFHDLLEK 205
            .......:..         .::.||......:||           |.|      |:.|
Frog   815 LEDRKALSKNQISALKSFERSSSKPVSEVCESSS-----------PDDDDNVPLFELR------- 861

  Fly   206 HKVLKTKYEKQTEDM--GELESMPQQLEETQNKLIETESSLKNTQSDNECLQRQVKQHTAKIETI 268
            .|:||...|:.|:..  .:|:|:..   ..|.|.::.:||......|...:||:|| .||:...|
Frog   862 KKLLKKNKEQLTDSQVDRDLDSLSM---AAQAKFLDFDSSQSVLSQDQSPIQRKVK-GTARSPNI 922

  Fly   269 TSTLGRTKEELSELQAIHE-----------KVKTEHAA----LSTEVVHLRQRTEEL-------- 310
            .|:...|...|.::..|.:           .||:|..:    .||......:|..|.
Frog   923 DSSSSETDVSLDQIITISDDSEDEKKPSISSVKSEKTSPKVCPSTSTSEFSKRIAEAQIKPEPPP 987

  Fly   311 -LRCN--EQQAAELETCKEQLF----QSNMERKE-----LHNTVMDLRGNIRVFCRIRPPLE--- 360
             |.|.  :.|..|.|| ::::|    ..::::||     ||:..            .:||:.
Frog   988 PLTCEDYDSQFFEFET-EDEVFSVWQDPDVDQKEPVIAPLHSEA------------AKPPISDPT 1039

  Fly   361 -SEENRMCCTWTYHDE-----------STVEL------QSIDAQAKSKMGQQIFSFDQVFHPLSS 407
             ::.|.....|.|..:           ...||      :.:..:.|:|..:..||...|     |
Frog  1040 GNDLNNEFDQWGYDTDDISDDVLEKAAEAAELSDSKPSKGLQKKPKAKGSEGTFSVKGV-----S 1099

  Fly   408 QSDIFEMVSPLIQSALDGYNICIFAYGQTGSGKTYTMDGVPESVGVIPRTVDLLFDSIRGYRNLG 472
            .|..:....|:.....:..||      .|...||.::..                ..:||
Frog  1100 SSSFYRKDVPIAAKHKEKANI------HTSPKKTSSLSS----------------KVVRG----- 1137

  Fly   473 WEYEIKATFLEIYNEVLYDLLSNEQKDMEIRMAKNNKNDIYVSNITEETVLDPNHLRHLMHTAKM 537
                 |.|...:..:::....:|..|.......:|.:.:..:.  |...|:.|..:|    .|..
Frog  1138 -----KKTETVVAQKIISKSKANRTKSPLRSRGENVRRENLIR--TSPAVVPPKKIR----MAPE 1191

  Fly   538 NRATASTAGNERSSRSHAVTKLELIGRHAEKQEISVGSI-NLVDLAGSESPKTSTRMTETKNINR 601
            ..:||...|.:::.|.    ..:|..|..:    ||..: |...:||...||    .|:.|.|:.
Frog  1192 PSSTAEKLGFKKAPRK----AFDLSQRSLD----SVAELRNHGKMAGFVEPK----KTKAKLISP 1244

  Fly   602 SLSELTNVILALLQKQDHIPYRNSKLTHLLMPSLGGNSKTLMFINVSPFQDCFQE---------- 656
            . |.|......:|..||...||.|:      |::.|..|     .....:|..::
Frog  1245 Q-SLLVKCNKKMLACQDLQFYRQSR------PNVPGKRK-----QAEALEDGNRKIENAAHKIDK 1297

  Fly   657 --SVKSLRFAASVNSCKMTKAKRNRYLNNSVAN-----SSTQSNNS 695
              :..|..|.|:.:..:....|.......|::|     |.|.||.|
Frog  1298 NGTSSSRHFQATTSHAEAISNKPRDERKLSISNEHLEISRTSSNKS 1343

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ncd	NP_001287592.1	KISc_C_terminal	346..672	CDD:276817	63/359 (18%)
ncd	NP_001287592.1	KISc	348..678	CDD:214526	64/363 (18%)
setx	XP_002936221.1	DEXXQc_SETX	1840..2157	CDD:350800
		AAA_12	2128..2323	CDD:404073
		PHA03247	<2365..2534	CDD:223021
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0239
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900