DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Drice and CFLAR

DIOPT Version :9

Sequence 1:	NP_524551.2	Gene:	Drice / 43514	FlyBaseID:	FBgn0019972	Length:	339	Species:	Drosophila melanogaster
Sequence 2:	NP_001120655.1	Gene:	CFLAR / 8837	HGNCID:	1876	Length:	480	Species:	Homo sapiens

Alignment Length:	292	Identity:	68/292 - (23%)
Similarity:	109/292 - (37%)	Gaps:	75/292 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 VAGSSHPYGSGAIGQLANGYSSPSSSYR-------------------KNVAKMVTDRHA------ 83
            |.|:...|.:.....:......||:::|                   :.|.|.:.:..|
Human   175 VQGAGTSYRNVLQAAIQKSLKDPSNNFRLHNGRSKEQRLKEQLGAQQEPVKKSIQESEAFLPQSI 239

  Fly    84 --AEYNMRHKNRGMALIFNHEHFEVPTLKSRAGTNVDC-ENLTRVLK----QLDFEVTVYKDCRY 141
              ..|.|:.|..|:.||                  :|| .|.|.:|:    .|.:||..:.....
Human   240 PEERYKMKSKPLGICLI------------------IDCIGNETELLRDTFTSLGYEVQKFLHLSM 286

  Fly   142 KDILRTI-EYAASQNHSDSDCILVAILSHGEMGYIYAKDTQYK---LDNIWSFFTANHCPSLAGK 202
            ..|.:.: ::|....|.|.|..:..::|.|....:|..|..:.   |.:|...|..:.||.||||
Human   287 HGISQILGQFACMPEHRDYDSFVCVLVSRGGSQSVYGVDQTHSGLPLHHIRRMFMGDSCPYLAGK 351

  Fly   203 PKLFFIQ---ACQGDRLDGGVTMQRSQTETDGDS--SMSYK------IPVH--ADFLIAYSTVPG 254
            ||:||||   ..:|...|.      |..|.||.:  ::.:|      ..||  |||..:..|...
Human   352 PKMFFIQNYVVSEGQLEDS------SLLEVDGPAMKNVEFKAQKRGLCTVHREADFFWSLCTADM 410

  Fly   255 FYSWRNTTRGSWFMQSLCAELAANGKR--LDI 284
            ....::.:..|.::|.|..:|....||  ||:
Human   411 SLLEQSHSSPSLYLQCLSQKLRQERKRPLLDL 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Drice	NP_524551.2	CASc	86..330	CDD:214521	59/223 (26%)
CFLAR	NP_001120655.1	Not proteolytically processed and involved in apoptosis inhibition	1..435		64/283 (23%)
		Interaction with CASP8 propeptide. /evidence=ECO:0000269\|PubMed:9208847, ECO:0000269\|PubMed:9326610	1..305		26/147 (18%)
		Interaction with FADD. /evidence=ECO:0000269\|PubMed:9208847, ECO:0000269\|PubMed:9326610	1..227		7/51 (14%)
		Interaction with CASP8. /evidence=ECO:0000269\|PubMed:9208847, ECO:0000269\|PubMed:9326610	1..195		3/19 (16%)
		DED_c-FLIP_r1	1..80	CDD:260044
		DED_c-FLIP_r2	91..171	CDD:260046
		Interaction with TRAF1 and TRAF2. /evidence=ECO:0000269\|PubMed:9208847	192..480		65/275 (24%)
		Interaction with CASP3. /evidence=ECO:0000269\|PubMed:9208847, ECO:0000269\|PubMed:9326610	192..435		61/266 (23%)
		Interaction with CASP8 subunits p18 and p10. /evidence=ECO:0000269\|PubMed:9208847, ECO:0000269\|PubMed:9326610	217..480		62/250 (25%)
		CASc	244..479	CDD:214521	59/223 (26%)
		Caspase	263..358		27/94 (29%)
		Interaction with CASP8. /evidence=ECO:0000269\|PubMed:9208847, ECO:0000269\|PubMed:9326610	370..480		19/79 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3573
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810