DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Drice and CASP9

DIOPT Version :9

Sequence 1:	NP_524551.2	Gene:	Drice / 43514	FlyBaseID:	FBgn0019972	Length:	339	Species:	Drosophila melanogaster
Sequence 2:	XP_011540575.1	Gene:	CASP9 / 842	HGNCID:	1511	Length:	421	Species:	Homo sapiens

Alignment Length:	322	Identity:	94/322 - (29%)
Similarity:	134/322 - (41%)	Gaps:	67/322 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 ESADQVGIR--VGNPEQPNDHTDALGSVGSGGAGSSGLVAGSSHPYGSGAIGQLANGYSSPSSSY 70
            |:...|.:|  :..||.....|.....:||||.|..|.:                       .|.
Human   104 ENLTPVVLRPEIRKPEVLRPETPRPVDIGSGGFGDVGAL-----------------------ESL 145

  Fly    71 RKNVAKMVTDRHAAEYNMRHKNRGMALIFNHEHF-EVPTLKSRAGTNVDCENLTRVLKQLDFEVT 134
            |.|.        ...|.:..:..|..||.|:.:| ....|::|.|:|:|||.|.|....|.|.|.
Human   146 RGNA--------DLAYILSMEPCGHCLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVE 202

  Fly   135 VYKDCRYKDILRTIEYAASQNHSDSDCILVAILSHGEM-------GYIYAKD-TQYKLDNIWSFF 191
            |..|...|.::..:...|.|:|...||.:|.|||||..       |.:|..| ....::.|.:.|
Human   203 VKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIF 267

  Fly   192 TANHCPSLAGKPKLFFIQACQGDRLDGGVTMQRSQTETDGDSS--------------------MS 236
            ....||||.|||||||||||.|::.|.|..:..:..|.:...|                    ..
Human   268 NGTSCPSLGGKPKLFFIQACGGEQKDHGFEVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAI 332

  Fly   237 YKIPVHADFLIAYSTVPGFYSWRNTTRGSWFMQSL--CAELAANGKRLDILTL---LTFVCQ 293
            ..:|..:|..::|||.|||.|||:...|||::::|  ..|..|:.:.|..|.|   ..|:|:
Human   333 SSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVSAAFLCK 394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Drice	NP_524551.2	CASc	86..330	CDD:214521	79/242 (33%)
CASP9	XP_011540575.1	CARD_CASP9	17..90	CDD:176740
CASP9	XP_011540575.1	CASc	152..397	CDD:237997	79/243 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3573
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10454
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910