Protein Alignment Drice and CASP8

DIOPT Version :10

• Sequence 1: NP_524551.2
• Gene: Drice / 43514
• FlyBaseID: FBgn0019972
• Length: 339
• Species: Drosophila melanogaster
• Sequence 2: NP_001073594.1
• Gene: CASP8 / 841
• HGNCID: 1509
• Length: 538
• Species: Homo sapiens
• Alignment Length: 307
• Identity: 112/307 - (36%)
• Similarity: 158/307 - (51%)
• Gaps: 35/307 - (11%)

  Fly    41 SGLVAGSSHPYGSGAIGQLANGYSSPSSSYRKNVAKMVT-DRHAAEYNMRHKNRGMALIFNHEHF 104
            |..:.||...:.:|.  :|. |..:.|.|.|:..::..| |:   .|.|:.|.||..||.|:.:|
Human   245 SSSLEGSPDEFSNGE--ELC-GVMTISDSPREQDSESQTLDK---VYQMKSKPRGYCLIINNHNF 303

  Fly   105 -----EVPTLKS---RAGTNVDCENLTRVLKQLDFEVTVYKDCRYKDILRTIEYAASQNHSDSDC 161
                 :||.|.|   |.||::|...||...::|.||:..:.||..:.|...::.....:||:.||
Human   304 AKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDC 368

  Fly   162 ILVAILSHGEMGYIYAKDTQ----YKLDNIWSFFTANHCPSLAGKPKLFFIQACQGDRLDGGVTM 222
            .:..|||||:.|.||..|.|    |:|.   |.||...|||||||||:|||||||||....|:.:
Human   369 FICCILSHGDKGIIYGTDGQEAPIYELT---SQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPV 430

  Fly   223 -----QRSQTETDGDSSMSYKIPVHADFLIAYSTVPGFYSWRNTTRGSWFMQSLCAELAANGKR- 281
                 ::...|.|..|..:..||..||||:..:||....|:||...|:|::||||..|.....|
Human   431 ETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRG 495

  Fly   282 LDILTLLTFVCQRVAVDFESCTPDTPEMHQQKQIPCITTMLTRILRF 328
            .||||:||      .|::|....| .:.:..||:|..|..|.:.|.|
Human   496 DDILTILT------EVNYEVSNKD-DKKNMGKQMPQPTFTLRKKLVF 535

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Drice	NP_524551.2	CASc	86..330	CDD:214521	101/261 (39%)
CASP8	NP_001073594.1	DED_Caspase_8_r1	62..143	CDD:260041
		DD	157..239	CDD:472698
		CASc	284..536	CDD:237997	101/262 (39%)