DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Drice and Casp12

DIOPT Version :9

Sequence 1:	NP_524551.2	Gene:	Drice / 43514	FlyBaseID:	FBgn0019972	Length:	339	Species:	Drosophila melanogaster
Sequence 2:	NP_569106.1	Gene:	Casp12 / 156117	RGDID:	621758	Length:	420	Species:	Rattus norvegicus

Alignment Length:	215	Identity:	58/215 - (26%)
Similarity:	98/215 - (45%)	Gaps:	23/215 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 MVTDRHAAEYNMRHK--NRGMALIFNHEHFEVPTLKSRAGTNVDCENLTRVLKQLDFEVTVYKDC 139
            |.|:|....|.:..|  ...:|||..::.|:.  |..|.....|..|:..:|:.|.:.|.:.::.
  Rat   158 MKTERAEEIYPVMEKEGRTRLALIICNKKFDY--LFDRDDAETDILNMKELLQNLGYSVVIKENL 220

  Fly   140 RYKDI-LRTIEYAASQNHSDSDCILVAILSHGEM-GYIYAKDTQYKL-----DNIWSFFTANHCP 197
            ..::: ...:::|....|..||...:..:|||.: |....|....|.     |.|::.|..::||
  Rat   221 TAQEMETELMKFAGRPEHQSSDSTFLVFMSHGILEGICGVKHRNKKPDVLHDDTIFTIFNNSNCP 285

  Fly   198 SLAGKPKLFFIQACQGDRLDGGVTMQRSQ----TETDGDSSMSY-------KIPVHADFLIAYST 251
            ||..|||:..:|||:| |..|.:.:..|:    .:||.:..:|:       |..|..||:...|:
  Rat   286 SLRNKPKILIMQACRG-RHTGTIWVSTSKGIATADTDEECVLSHRWNNSITKAHVETDFIAFKSS 349

  Fly   252 VPGFYSWRNTTRGSWFMQSL 271
            .|...||:....||.|:..|
  Rat   350 TPHNISWKVGKSGSLFISKL 369

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Drice	NP_524551.2	CASc	86..330	CDD:214521	55/206 (27%)
Casp12	NP_569106.1	CARD_CASP1-like	6..88	CDD:260036
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	93..115
		CASc	167..418	CDD:214521	55/206 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3573
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10454
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910