DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Drice and Cflar

DIOPT Version :9

Sequence 1:	NP_524551.2	Gene:	Drice / 43514	FlyBaseID:	FBgn0019972	Length:	339	Species:	Drosophila melanogaster
Sequence 2:	NP_001276633.1	Gene:	Cflar / 12633	MGIID:	1336166	Length:	481	Species:	Mus musculus

Alignment Length:	291	Identity:	74/291 - (25%)
Similarity:	118/291 - (40%)	Gaps:	65/291 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 SGGAGSSGLVAGSSHP-----YGSGAIGQLANGYSSPSS--SYRKNVAKMVTDR----------H 82
            |.||.|:.....:|.|     |.|    :|.||.|....  .||.:...:|...          |
Mouse   180 SQGARSNMNTLQASLPKLSIKYNS----RLQNGRSKEPRFVEYRDSQRTLVKTSIQESGAFLPPH 240

  Fly    83 AAE--YNMRHKNRGMALIFNHEHFEVPTLKSRAGTNVDC-ENLTRVLKQ----LDFEVTVYKDCR 140
            ..|  |.|:.|..|:.||                  :|| .|.|:.|::    |.:.:.::...:
Mouse   241 IREETYRMQSKPLGICLI------------------IDCIGNDTKYLQETFTSLGYHIQLFLFPK 287

  Fly   141 YKDILRTI-EYAASQNHSDSDCILVAILSHGEMGYIYAKD---TQYKLDNIWSFFTANHCPSLAG 201
            ..||.:.: .||:...|.|.|.....::|.|....:..:|   :.:.||::.:.||.:.||||.|
Mouse   288 SHDITQIVRRYASMAQHQDYDSFACVLVSLGGSQSMMGRDQVHSGFSLDHVKNMFTGDTCPSLRG 352

  Fly   202 KPKLFFIQACQGDRLDGGVTMQRSQTETDGDSSMSYKI----PVH------ADFLIAYSTVPGFY 256
            ||||||||..:    ..|..::.|..|.||.|..:...    |.|      ||...:..|....:
Mouse   353 KPKLFFIQNYE----SLGSQLEDSSLEVDGPSIKNVDSKPLQPRHCTTHPEADIFWSLCTADVSH 413

  Fly   257 SWRNTTRGSWFMQSLCAELAANGKRLDILTL 287
            ..:.::..|.::|.|..:| ..|:|..::.|
Mouse   414 LEKPSSSSSVYLQKLSQQL-KQGRRRPLVDL 443

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Drice	NP_524551.2	CASc	86..330	CDD:214521	57/221 (26%)
Cflar	NP_001276633.1	Interaction with CASP8 propeptide. /evidence=ECO:0000250\|UniProtKB:O15519	6..307		34/148 (23%)
		Interaction with FADD. /evidence=ECO:0000250\|UniProtKB:O15519	6..229		15/52 (29%)
		Interaction with CASP8. /evidence=ECO:0000250\|UniProtKB:O15519	6..200		6/19 (32%)
		DED_c-FLIP_r1	6..85	CDD:260044
		DED_c-FLIP_r2	96..176	CDD:260046
		Interaction with TRAF1 and TRAF2. /evidence=ECO:0000250\|UniProtKB:O15519	197..481		68/274 (25%)
		Interaction with CASP3. /evidence=ECO:0000250\|UniProtKB:O15519	197..436		65/265 (25%)
		Interaction with CASP8 subunits p18 and p10. /evidence=ECO:0000250\|UniProtKB:O15519	219..481		61/248 (25%)
		CASc	246..480	CDD:214521	57/221 (26%)
		Caspase	265..360		28/94 (30%)
		Interaction with CASP8. /evidence=ECO:0000250\|UniProtKB:O15519	372..481		17/73 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3573
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810