DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Drice and Casp9

DIOPT Version :9

Sequence 1:	NP_524551.2	Gene:	Drice / 43514	FlyBaseID:	FBgn0019972	Length:	339	Species:	Drosophila melanogaster
Sequence 2:	NP_056548.2	Gene:	Casp9 / 12371	MGIID:	1277950	Length:	454	Species:	Mus musculus

Alignment Length:	369	Identity:	109/369 - (29%)
Similarity:	155/369 - (42%)	Gaps:	75/369 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 NPE--QPNDH--TDALGSVGSGGAGSSGLVAGSSHPYGSGAIGQLANGYSSPSSSY----RKNVA 75
            :||  :|.||  ...||.:|........:....|.|    |:|.|......|...:    :..|.
Mouse    99 DPEAVKPLDHLVPVVLGPMGLTAKEQRVVKLDPSQP----AVGNLTPVVLGPEELWPARLKPEVL 159

  Fly    76 KMVTDR--------------------HA-AEYNMRHKNRGMALIFNHEHFEVPT--LKSRAGTNV 117
            :..|.|                    || ..|.:.....|..||.|:.:| .|:  |.:|.|:|:
Mouse   160 RPETPRPVDIGSGGAHDVCVPGKIRGHADMAYTLDSDPCGHCLIINNVNF-CPSSGLGTRTGSNL 223

  Fly   118 DCENLTRVLKQLDFEVTVYKDCRYKDILRTIEYAASQNHSDSDCILVAILSHGEM-------GYI 175
            |.:.|....:.|.|.|.|..|...|.::..:...|.:||...||.:|.|||||..       |.:
Mouse   224 DRDKLEHRFRWLRFMVEVKNDLTAKKMVTALMEMAHRNHRALDCFVVVILSHGCQASHLQFPGAV 288

  Fly   176 YAKD-TQYKLDNIWSFFTANHCPSLAGKPKLFFIQACQGDRLDGG--VTMQRSQTET-DGDS--- 233
            |..| ....::.|.:.|..:.||||.|||||||||||.|::.|.|  |....||..| |.||
Mouse   289 YGTDGCSVSIEKIVNIFNGSGCPSLGGKPKLFFIQACGGEQKDHGFEVACTSSQGRTLDSDSEPD 353

  Fly   234 SMSYK--------------IPVHADFLIAYSTVPGFYSWRNTTRGSWFMQSLCAELAANGKRLDI 284
            ::.|:              :|..:|.|::|||.|||.|||:...|||::::|...|....:..|:
Mouse   354 AVPYQEGPRPLDQLDAVSSLPTPSDILVSYSTFPGFVSWRDKKSGSWYIETLDGILEQWARSEDL 418

  Fly   285 LTLLTFVCQRVAVDFESCTPDTPEMHQQKQIPCITTMLTRILRF 328
            .:||..|...|:.           ....||||.....|.:.|.|
Mouse   419 QSLLLRVANAVSA-----------KGTYKQIPGCFNFLRKKLFF 451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Drice	NP_524551.2	CASc	86..330	CDD:214521	90/273 (33%)
Casp9	NP_056548.2	CARD_CASP9	5..90	CDD:176740
Casp9	NP_056548.2	CASc	190..452	CDD:237997	90/274 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3573
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10454
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910