DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Drice and Casp1

DIOPT Version :9

Sequence 1:	NP_524551.2	Gene:	Drice / 43514	FlyBaseID:	FBgn0019972	Length:	339	Species:	Drosophila melanogaster
Sequence 2:	NP_033937.2	Gene:	Casp1 / 12362	MGIID:	96544	Length:	402	Species:	Mus musculus

Alignment Length:	249	Identity:	68/249 - (27%)
Similarity:	109/249 - (43%)	Gaps:	27/249 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 MALIFNHEHFEVPTLKSRAGTNVDCENLTRVLKQLDFEVTVYKDCRYKDILRTI-EYAASQNHSD 158
            :|||..:..|:  .|..|.|..||...:..:|:.|.:.|.|.::....::::.: |:||...|..
Mouse   163 LALIICNTEFQ--HLSPRVGAQVDLREMKLLLEDLGYTVKVKENLTALEMVKEVKEFAACPEHKT 225

  Fly   159 SDCILVAILSHGEM----GYIYAKDTQ--YKLDNIWSFFTANHCPSLAGKPKLFFIQACQGDRLD 217
            ||...:..:|||..    |..|:.:..  .|:|.|:.......||||..|||:..||||:|:: .
Mouse   226 SDSTFLVFMSHGIQEGICGTTYSNEVSDILKVDTIFQMMNTLKCPSLKDKPKVIIIQACRGEK-Q 289

  Fly   218 GGVTMQRSQTETDGD--------SSMSYKIPVHADFLIAYSTVPGFYSWRNTTRGSWFMQSLCAE 274
            |.|.::.|..:::.|        .....|..:..||:...|:.|...|||:..|||.|::||...
Mouse   290 GVVLLKDSVRDSEEDFLTDAIFEDDGIKKAHIEKDFIAFCSSTPDNVSWRHPVRGSLFIESLIKH 354

  Fly   275 LAANGKRLDILTLLTFVCQRVAVDFESCTPDTPEMHQQKQIPCITTMLTRILRF 328
            :.......|    |..:.::|...||.     ||...|.......|:..|...|
Mouse   355 MKEYAWSCD----LEDIFRKVRFSFEQ-----PEFRLQMPTADRVTLTKRFYLF 399

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Drice	NP_524551.2	CASc	86..330	CDD:214521	68/249 (27%)
Casp1	NP_033937.2	CARD_CASP1-like	6..87	CDD:260036
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	98..125
		CASc	152..400	CDD:214521	68/249 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3573
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10454
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910