DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Drice and Casp4

DIOPT Version :9

Sequence 1:	NP_524551.2	Gene:	Drice / 43514	FlyBaseID:	FBgn0019972	Length:	339	Species:	Drosophila melanogaster
Sequence 2:	NP_446188.2	Gene:	Casp4 / 114555	RGDID:	621757	Length:	373	Species:	Rattus norvegicus

Alignment Length:	255	Identity:	73/255 - (28%)
Similarity:	117/255 - (45%)	Gaps:	49/255 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 ALIFNHEHFEVPTLKSRAGTNVDCENLTRVLKQLDFEVTVYKDCRYKDILRTI-EYAASQNHSDS 159
            |||..:..|:  .|..|.|.|:|...:..:|::|.::|.|.::...:.:...: ::||...|..|
  Rat   134 ALIICNTEFK--HLSLRYGANIDISGMKGLLEELGYDVVVKEELTAEGMESEMKDFAALSEHQTS 196

  Fly   160 DCILVAILSHGEM----GYIYAKDTQYKL--DNIWSFFTANHCPSLAGKPKLFFIQACQGDRLDG 218
            |...:.::|||.:    |.::::.|...|  |.|:..|...|||.|..|||:..:|||:|.. .|
  Rat   197 DSTFLVLMSHGTLQGLCGTMHSEATPDVLLYDTIYQIFNNCHCPGLRDKPKVIIVQACRGGN-PG 260

  Fly   219 GVTMQRSQTETDGDSSMSYK---IP------------VHADFLIAYSTVPGFYSWRNTTRGSWFM 268
            .|.::.|      ..:.||:   :|            |..||:..|||.|...|:|:.||||:|:
  Rat   261 EVWIRES------SGAHSYRAVDLPRNMEADAVRMSHVEKDFIALYSTTPHHLSYRDKTRGSYFI 319

  Fly   269 QSL--CAELAANGKRL-DILTLLTFVCQRVAVDFESCTPDTPEMHQQKQIPCI-TTMLTR 324
            ..|  |..:.|....| ||..       :|...||..:.::       |:|.| ...|||
  Rat   320 SKLISCFRIHACSCHLFDIFL-------KVQQSFEKASINS-------QMPTIDRATLTR 365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Drice	NP_524551.2	CASc	86..330	CDD:214521	73/255 (29%)
Casp4	NP_446188.2	CARD_CASP1-like	5..85	CDD:260036
Casp4	NP_446188.2	CASc	122..371	CDD:214521	73/255 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3573
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10454
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910