Protein Alignment Rnb and ARMC5

DIOPT Version :9

• Sequence 1: NP_651726.1
• Gene: Rnb / 43513
• FlyBaseID: FBgn0039696
• Length: 975
• Species: Drosophila melanogaster
• Sequence 2: NP_001275696.1
• Gene: ARMC5 / 79798
• HGNCID: 25781
• Length: 1030
• Species: Homo sapiens
• Alignment Length: 991
• Identity: 205/991 - (20%)
• Similarity: 320/991 - (32%)
• Gaps: 281/991 - (28%)

  Fly    18 STDRTVIYKCLVKLRTDLVKDKNGIVLFRTAGGVHIMVRLITKLN-------------------- 62
            :|:.|.:.:.|:.|||..:|...||..||..||:..::.|:.:..
Human   129 ATNETPLSRALLALRTRHIKAAGGIERFRARGGLRPLLALLRRAAAAGSAPSQAGPGSAPSSAAS 193

  Fly    63 ---------------------------EKIMEVVLSILGNCCTDEQSCIEAVECKVIHPLVTILK 100
                                       .|.:::.||||.:|||:.....|......|.||||||:
Human   194 GASSPAPASGPAPSAVSSSSPTPPVRLRKTLDLALSILADCCTEGACRTEVRRLGGILPLVTILQ 258

  Fly   101 TIPNPLIQCRACRMLGNIAKSKKASQCLTVHYAAIAPAICHIIESTSAVQTRIMAFRVCRFL--L 163
            .:....||.|..|.|||:|...::  |..:|.|...|.   ::||.:|.|.......|.|.|  |
Human   259 CMKTDSIQNRTARALGNLAMEPES--CGDIHCAGAVPL---LVESLTACQDSQCLQSVVRALRNL 318

  Fly   164 ASSQFLKYFLMANGFQQLMRIFLAVMKNEEASKEPVPDIEMSTLIGLKRNQHREKYFEEVARNLE 228
            |.|...:..|...|..:.:...||.          .||                     .|..|.
Human   319 ADSPQHRLALAQQGAVRPLAELLAT----------APD---------------------AALTLA 352

  Fly   229 GVRSDIFDHQMLKNSTRNCDYALPKENEAAVELALEILKCLVLISAQQIGLKVWESISWNTSLAS 293
            .||:       |...:|.|..|                 |.             |.:|....|..
Human   353 LVRA-------LLELSRGCSRA-----------------CA-------------EQLSLGGGLGP 380

  Fly   294 IVCFVKEDGDQ-RASALKILSNFCKDPFAFYMLSTADAIVAACEMLMA---VNMAKPLSESESRH 354
            :|......... |...:.||:|.|........|..|..:....:.|..   .|.|.|.|:   :.
Human   381 LVSLASHPKRAVREGTILILANLCAQGLIRPALGNAGGVEVLVDELRQRRDPNGASPTSQ---QP 442

  Fly   355 CINIILTLSTDACSRSKIRRCGALRKLVAMIRDSNSQSERSSLFHILYNFQYDNLSMELMLYEGL 419
            .:..:..|..:|.:|:::|..|.|..|:.::||..:.:....:...|..|.||..::..:...||
Human   443 LVRAVCLLCREAINRARLRDAGGLDLLMGLLRDPRASAWHPRIVAALVGFLYDTGALGRLQALGL 507

  Fly   420 MPMLVRELNDYLTSDDEHHK---------RRRDERLQGGKKRKLTDPTTPETLSKFSKTHETLGS 475
            :|:|..:|......::|..:         .|..||.|||..|.|......|..:        .|.
Human   508 VPLLAGQLCGEAGEEEEEGREAASWDFPEERTPERAQGGSFRSLRSWLISEGYA--------TGP 564

  Fly   476 DFESPSSSPRSYRTTSPCSSRSMSPVCTDLLTNDDDDNYSPACSDDDEDEDDSTNNSNLDTRERR 540
            |..||..||..      |....|.|.             |||          .|..|....|.:|
Human   565 DDISPDWSPEQ------CPPEPMEPA-------------SPA----------PTPTSLRAPRTQR 600

  Fly   541 I-----AANRSQP----SNVLDILKLIEEGSEPIDDPLSDKEDLEELSSDV-----PPKLAPFR- 590
            .     ||...:|    ...|.:|....:..:| ...|.....|..|.:.|     ||.....|
Human   601 TPGRSPAAAIEEPWGREGPALLLLSRFSQAPDP-SGALVTGPALYGLLTYVTGAPGPPSPRALRI 664

  Fly   591 --NTTCNTIDIIENLIYRITLMVNKRVELGKPETLD--------TLIRAIKLFG-SNNNFPNALT 644
              ..|||                        |..|:        .|:||..:.| :.:::|....
Human   665 LSRLTCN------------------------PACLEAFVRSYGAALLRAWLVLGVAPDDWPAPRA 705

  Fly   645 NILLESQFFAQIIKHGVVHQLYQFTKLKEIRKDGFAFLETLTNVGESNYGKEELVRLLRCDDVIS 709
            ...|.|       :|               |:.|...|:.||...||.:|...|..||.......
Human   706 RPTLHS-------RH---------------RELGERLLQNLTVQAESPFGVGALTHLLLSGSPED 748

  Fly   710 QQRAAISVAYIVKSHRLLYQFLYDGNALNMLFDMMLRKKTEDHYADEAADAVT---SMARYTLGI 771
            :...|:::.:|.:...|..:.|.:...|.:|...:.|......:...|||:::   .:...|:..
Human   749 RVACALTLPFICRKPSLWRRLLLEQGGLRLLLAALTRPAPHPLFLFFAADSLSCLQDLVSPTVSP 813

  Fly   772 VMPEAEP--AESTAGICNQIANDTAPLHANCDMRFLVGHGADSTSIGFNKQLLCDTSEVFNKMLN 834
            .:|:|.|  .:|.:....:.....||:.|. |:.||:..|   ..:...:......|..|..:|:
Human   814 AVPQAVPMDLDSPSPCLYEPLLGPAPVPAP-DLHFLLDSG---LQLPAQRAASATASPFFRALLS 874

  Fly   835 SDFREGHQGEIQLPDYTASGLRYFLHLIVCQERHL-------------TEPDYPAL----LQAYE 882
            ..|.|.....:.|...:.......||       ||             ..|..|.|    .:|.|
Human   875 GSFAEAQMDLVPLRGLSPGAAWPVLH-------HLHGCRGCGAALGPVPPPGQPLLGSEAEEALE 932

  Fly   883 MARVYIMPDMEAVLQQ 898
            .|..:::|.:|..|::
Human   933 AAGRFLLPGLEEELEE 948

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rnb	NP_651726.1	ARM	44..147	CDD:237987	35/149 (23%)
		armadillo repeat	49..78	CDD:293788	9/75 (12%)
		armadillo repeat	84..118	CDD:293788	14/33 (42%)
		BTB	801..904	CDD:197585	23/115 (20%)
ARMC5	NP_001275696.1	ARM	243..353	CDD:237987	38/145 (26%)
		armadillo repeat	244..276	CDD:293788	13/31 (42%)
		armadillo repeat	284..319	CDD:293788	10/37 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147700
Domainoid	1	1.000	102	1.000	Domainoid score	I6904
eggNOG	1	0.900	-	-		E1_28KHM
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D174815at2759
OrthoFinder	1	1.000	-	-		FOG0007945
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR23312
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5326
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.880