DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rnb and Armc5

DIOPT Version :9

Sequence 1:	NP_651726.1	Gene:	Rnb / 43513	FlyBaseID:	FBgn0039696	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	NP_001009455.1	Gene:	Armc5 / 361653	RGDID:	1306553	Length:	926	Species:	Rattus norvegicus

Alignment Length:	983	Identity:	203/983 - (20%)
Similarity:	327/983 - (33%)	Gaps:	268/983 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 STDRTVIYKCLVKLRTDLVKDKNGIVLFRTAGGVHIMVRLITKLN-------------------- 62
            :|:.|.:.:.|:.|||..:|...||..||..||:..:|.|:.:..
  Rat    34 ATNETALGRVLLALRTRHIKAAEGIERFRARGGLRPLVALLRRTAAAGPAPSQAASGSAPPSVAS 98

  Fly    63 -----------------------EKIMEVVLSILGNCCTDEQSCIEAVECKVIHPLVTILKTIPN 104
                                   .|.:::.||||.||||:.....|......|.||||||:.:..
  Rat    99 AGSSPGPAPAAESPLTLSAPMRLRKTLDLALSILANCCTEGACRSEVRRIGGILPLVTILQCVRI 163

  Fly   105 PLIQCRACRMLGNIAKSKKASQCLTVHYAAIAPAICHIIESTSAVQTRIMAFRVCRFLLASSQFL 169
            ..||.|..|.|||:|...::  |..:|.|...|   .::||.:|.|              .||.|
  Rat   164 DSIQNRTARALGNLAMEPES--CGDIHSAGAVP---FLVESLTACQ--------------DSQCL 209

  Fly   170 KYFLMANGFQQLMRIFLAVMKNEEASKEPVPDIEMSTLIGLKRNQHREKYFEEVA-RNLEGVRSD 233
                     |.::|    .::|...|.                 |||....::.| |.|..:.:.
  Rat   210 ---------QSIVR----ALRNLADSP-----------------QHRLALAQQGAVRPLAELLAT 244

  Fly   234 IFDHQMLKNSTRNCDYALPKENEAAVELALEILKCLVLISAQQIGLKVWESISWNTSLASIVCFV 298
            ..|               |....|.|...||:.:......|:|:.|        ...|..:|...
  Rat   245 APD---------------PALTSALVRALLELSRGCSRACAEQLSL--------GGGLGPLVSLA 286

  Fly   299 KEDGDQ-RASALKILSNFCKDPFAFYMLSTADAIVAACEMLMAVNMAKPLSESESRHCINIILTL 362
            ...... |.:|:.||:|.|........|..|..:......|.........|.:..:..:..:..|
  Rat   287 SHPKRAIREAAILILANLCAQGLVRPALGNAGGVEVLLGELRRRRGPSGSSSASQQPLVRAVCLL 351

  Fly   363 STDACSRSKIRRCGALRKLVAMIRDSNSQSERSSLFHILYNFQYDNLSMELMLYEGLMPMLVREL 427
            ..:|.:|:::|..|.|..|:.:::|..:.:....:...|..|.||..::..:...||:|:|.|:|
  Rat   352 CREAINRARLRDAGGLELLMGLLQDPGASAWHPRVVAALVGFLYDTGALGKLQALGLVPLLARQL 416

  Fly   428 NDYLTSDDEH---------HKRRRDERLQGGKKRKLTDPTTPETLSKFSKTHETLGSDFESPSSS 483
            ......::|.         .:.|...:.:||..|.|       .|...|:.:.....|. ||..|
  Rat   417 CGEAGEEEEEGVEAASWDFPEERTSGQPEGGSFRSL-------RLWLISEGYAAGPGDI-SPDWS 473

  Fly   484 PRSYRTTSPCSSRSMSPVCTDLLTNDDDDNYSPACSDDDEDEDDSTNNSNLDTRERRIAANRSQP 548
            |.  |...|..|.|:||              :|.       :...:....|....|..||...:|
  Rat   474 PE--RCPMPEPSESVSP--------------TPG-------QTSMSTPRTLRKLGRVPAATTEEP 515

  Fly   549 ----SNVLDILKLIEEGSEPIDDPLSDKEDLEELSSDV-----PPKLAPFR---NTTCNTIDIIE 601
                ...|.:|....:..:| ...|.....|..|.:.|     ||.....|   ..|||
  Rat   516 WGQEGPALLLLSRFSQAPDP-SGALVTGPALCGLLAYVTGAPGPPNPRALRILARLTCN------ 573

  Fly   602 NLIYRITLMVNKRVELGKPETLD--------TLIRAIKLFG-SNNNFPNALTNILLESQFFAQII 657
                              |..|:        .|:||..:.| |.:::|                :
  Rat   574 ------------------PACLEAFVRSYGAALLRAWLVLGVSPDDWP----------------V 604

  Fly   658 KHG-VVHQLYQFTKLKEIRKDGFAFLETLTNVGESNYGKEELVRLLRCDDVISQQRAAISVAYIV 721
            .|. .||:       .:.|:.|...|:.||...||.:|...|..||.......:...|::|.:|.
  Rat   605 PHARPVHR-------SQHRELGEMLLQNLTVQAESPFGVGALTHLLLSGSPEDRVACALTVPFIC 662

  Fly   722 KSHRLLYQFLYDGNALNMLFDMMLRKKTEDHYADEAADAVTSMARYTLGIVMPEAEPA------- 779
            :...|..:.|.|...|.:|...:.:......:...|||:::.:.    |:|.|.|.|.
  Rat   663 RKPTLWRRLLLDQGGLRLLLTALTQPAPHPLFLFFAADSLSCLQ----GLVSPSASPVPLPDLPL 723

  Fly   780 --ESTAGICNQIANDTAPLHANCDMRFLVGHGADSTSIGFNKQLLCDTSEVFNKMLNSDFREGHQ 842
              :|.:....:.....||..|. |:.|::..|   ..:...:......|..|..:|:..|.|...
  Rat   724 ELDSPSPCLYKPLLGPAPAPAP-DLHFVLDSG---LQLPAQRAASAAASPFFRALLSGSFAEAQM 784

  Fly   843 GEIQLPDYTASGLRYFLHLIVCQERHL-------------TEPDYPAL----LQAYEMARVYIMP 890
            ..:.|...:.|.....||       ||             ..|..|.|    .:|.|.|..:::|
  Rat   785 NLVPLRGLSPSAAWPVLH-------HLHGCRGCGAALGPIPPPGQPLLGSKAEEALEAAGRFLLP 842

  Fly   891 DMEAVLQQ 898
            .:|..|::
  Rat   843 ALEEELEE 850

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rnb	NP_651726.1	ARM	44..147	CDD:237987	37/145 (26%)
		armadillo repeat	49..78	CDD:293788	11/71 (15%)
		armadillo repeat	84..118	CDD:293788	14/33 (42%)
		BTB	801..904	CDD:197585	23/115 (20%)
Armc5	NP_001009455.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	82..113		0/30 (0%)
		ARM 1	139..179		15/39 (38%)
		armadillo repeat	142..179	CDD:293788	15/36 (42%)
		ARM	144..263	CDD:237987	43/182 (24%)
		ARM 2	181..221		14/71 (20%)
		armadillo repeat	185..219	CDD:293788	12/63 (19%)
		ARM 3	223..263		12/71 (17%)
		armadillo repeat	226..263	CDD:293788	10/51 (20%)
		ARM 4	267..306		10/46 (22%)
		armadillo repeat	270..304	CDD:293788	9/41 (22%)
		ARM 5	307..354		5/46 (11%)
		ARM 6	355..399		11/43 (26%)
		ARM 7	401..440		7/38 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	467..498		12/54 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341527
Domainoid	1	1.000	102	1.000	Domainoid score	I6728
eggNOG	1	0.900	-	-		E1_28KHM
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	102	1.000	Inparanoid score	I4872
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D174815at2759
OrthoFinder	1	1.000	-	-		FOG0007945
OrthoInspector	1	1.000	-	-		oto98002
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR23312
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.860