Protein Alignment sro and HSD17B6

DIOPT Version :10

• Sequence 1: NP_651725.1
• Gene: sro / 43512
• FlyBaseID: FBgn0262112
• Length: 335
• Species: Drosophila melanogaster
• Sequence 2: NP_003716.2
• Gene: HSD17B6 / 8630
• HGNCID: 23316
• Length: 317
• Species: Homo sapiens
• Alignment Length: 311
• Identity: 89/311 - (28%)
• Similarity: 146/311 - (46%)
• Gaps: 44/311 - (14%)

  Fly    29 VLITGCDSGLGHSMAVYCHESLHMTVISCCHNIKSEGAKLLQGLASAKDGLSRMHTLELDLLEPD 93
            |.|||||||.|:.:|... ::..:.|::.|  :..:||:.|:|..|     .|:.|:.||:.:.:
Human    32 VFITGCDSGFGNLLARQL-DARGLRVLAAC--LTEKGAEQLRGQTS-----DRLETVTLDVTKME 88

  Fly    94 SIRLVHRQLRDILAKDPSYRLTALINNAGV-----MCFGEFEWQLTEQIEAQINCNLLGTMRLTH 153
            ||....:.:::.:.   ...|..|:||||:     :|    ||..||.....:..||:|.:::|.
Human    89 SIAAATQWVKEHVG---DRGLWGLVNNAGILTPITLC----EWLNTEDSMNMLKVNLIGVIQVTL 146

  Fly   154 ELLPLLRQQQGRIINVTSHCGLQALPALGPYAASKAALRFWTDSLRVELQQYGMEVVNFIPGSFV 218
            .:|||:|:.:|||:||:|..|..|. .:|.|..||..:..::|.||.|:|.:|:::....||.|.
Human   147 SMLPLVRRARGRIVNVSSILGRVAF-FVGGYCVSKYGVEAFSDILRREIQHFGVKISIVEPGYFR 210

  Fly   219 LD-SNIAARQQQHAQKMREAFSAEQHALYDTYFEAFNGYLKVLSGFKPPNRLRNESLLAK-FKDA 281
            .. :|:....::..|..:||....:......||:|....:|  .|..  |...|.:|:.. .:.|
Human   211 TGMTNMTQSLERMKQSWKEAPKHIKETYGQQYFDALYNIMK--EGLL--NCSTNLNLVTDCMEHA 271

  Fly   282 LTSSQPLALYIEE--------PRRYRLYRWLFTLCPTPLVDWLTVRFCAMP 324
            |||..|...|...        |..|         .||.|.|::..|....|
Human   272 LTSVHPRTRYSAGWDAKFFFIPLSY---------LPTSLADYILTRSWPKP 313

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sro	NP_651725.1	17beta-HSD-like_SDR_c	27..300	CDD:187632	83/285 (29%)
HSD17B6	NP_003716.2	type2_17beta_HSD-like_SDR_c	30..306	CDD:187665	87/302 (29%)