Protein Alignment sro and RDH5

DIOPT Version :10

• Sequence 1: NP_651725.1
• Gene: sro / 43512
• FlyBaseID: FBgn0262112
• Length: 335
• Species: Drosophila melanogaster
• Sequence 2: NP_002896.2
• Gene: RDH5 / 5959
• HGNCID: 9940
• Length: 318
• Species: Homo sapiens
• Alignment Length: 314
• Identity: 97/314 - (30%)
• Similarity: 147/314 - (46%)
• Gaps: 40/314 - (12%)

  Fly    18 RQQLKVDSRHVVLITGCDSGLGHSMAVYCHESLHMTVISCCHNIKSEGAKLLQGLASAKDGLSRM 82
            ||.|.. |...|.|||||||.|..:|:...:.....:.||   :...||:.||.:||     ||:
Human    21 RQSLPA-SNAFVFITGCDSGFGRLLALQLDQRGFRVLASC---LTPSGAEDLQRVAS-----SRL 76

  Fly    83 HTLELDLLEPDSIRLVHRQLRDILAKDPSYRLTALINNAGVM-CFGEFEWQLTEQIEAQINCNLL 146
            ||..||:.:|.|::...:.: ::..|:..  |..|:|||||. ..|...|...:..:..:|.|.:
Human    77 HTTLLDITDPQSVQQAAKWV-EMHVKEAG--LFGLVNNAGVAGIIGPTPWLTRDDFQRVLNVNTM 138

  Fly   147 GTMRLTHELLPLLRQQQGRIINVTSHCGLQALPALGPYAASKAALRFWTDSLRVELQQYGMEVVN 211
            |.:.:|..|||||:|.:||:||:||..|..|... |.|..||..|..::||||.::..:|:.|..
Human   139 GPIGVTLALLPLLQQARGRVINITSVLGRLAANG-GGYCVSKFGLEAFSDSLRRDVAHFGIRVSI 202

  Fly   212 FIPGSFVLD-SNIAARQQQHAQKMREAFSAEQHALYDTYFEAF-NGYLKVLSGFKPPNRLRN--- 271
            ..||.|... :|:.:.:    :.::..::....|....|..|| ..|||:      ..|:.|
Human   203 VEPGFFRTPVTNLESLE----KTLQACWARLPPATQAHYGGAFLTKYLKM------QQRIMNLIC 257

  Fly   272 ESLLAK----FKDALTSSQPLALYIEEPRRYRLYRWL-FTLCPTPLVD----WL 316
            :..|.|    .:.|||:..|...|  .|.......|| .:..|..|||    |:
Human   258 DPDLTKVSRCLEHALTARHPRTRY--SPGWDAKLLWLPASYLPASLVDAVLTWV 309

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sro	NP_651725.1	17beta-HSD-like_SDR_c	27..300	CDD:187632	86/282 (30%)
RDH5	NP_002896.2	type2_17beta_HSD-like_SDR_c	30..306	CDD:187665	92/299 (31%)