DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sro and Hsd11b2

DIOPT Version :9

Sequence 1:	NP_651725.1	Gene:	sro / 43512	FlyBaseID:	FBgn0262112	Length:	335	Species:	Drosophila melanogaster
Sequence 2:	NP_058777.1	Gene:	Hsd11b2 / 25117	RGDID:	2835	Length:	400	Species:	Rattus norvegicus

Alignment Length:	338	Identity:	96/338 - (28%)
Similarity:	140/338 - (41%)	Gaps:	71/338 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLRALRRSLGLGR-------------------------------------------QQLKVDSRH 27
            ||:.||..|.|||                                           .:|.|.:|
  Rat    20 LLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATR- 83

  Fly    28 VVLITGCDSGLGHSMAVYCHESLHMTVISCCHNIKSEGAKLLQGLASAKDGLSRMHTLELDLLEP 92
            .|||||||:|.|...|... :::..||::...::...||..|:...|     .|:..|::||.:|
  Rat    84 AVLITGCDTGFGKETAKKL-DAMGFTVLATVLDLNGPGALELRARCS-----PRLKLLQMDLTKP 142

  Fly    93 DSIRLVHRQLRDILAKDPSYRLTALINNAGV-MCFGEFEWQLTEQIEAQINCNLLGTMRLTHELL 156
            :.|   .|.|....|...|..|..|:||||: |...:.|..........:..|..|.:.||..||
  Rat   143 EDI---SRVLEITKAHTASTGLWGLVNNAGLNMVVADVELSPVVTFRECMEVNFFGALELTKGLL 204

  Fly   157 PLLRQQQGRIINVTSHCGLQALPALGPYAASKAALRFWTDSLRVELQQYGMEVVNFIPGSF---- 217
            ||||..:|||:.|.|..|....|.|..|..||||:....|:...||..:|::|....||.|
  Rat   205 PLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFSCELLPWGIKVSIIQPGCFKTEA 269

  Fly   218 VLDSNIAARQQQ--HAQKMREAFSAEQHALY-DTYFEAFNG-YLKVLSGFKPPNRLRNESLLAKF 278
            |.:.|:..:::|  .|...||...|     | :.|.|..:| :|..|....|......::::
  Rat   270 VTNVNLWEKRKQLLLANLPRELLQA-----YGEDYIEHLHGQFLNSLRMALPDLSPVVDAII--- 326

  Fly   279 KDALTSSQPLALY 291
             |||.::||.:.|
  Rat   327 -DALLAAQPRSRY 338

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sro	NP_651725.1	17beta-HSD-like_SDR_c	27..300	CDD:187632	85/274 (31%)
sro	NP_651725.1	adh_short	28..229	CDD:278532	67/205 (33%)
Hsd11b2	NP_058777.1	type2_17beta_HSD-like_SDR_c	83..363	CDD:187665	86/275 (31%)
		adh_short	83..278	CDD:278532	68/204 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	378..400
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1610
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D370032at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR43313
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X110
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	7	6.880