Protein Alignment sro and Hsd11b2

DIOPT Version :10

• Sequence 1: NP_651725.1
• Gene: sro / 43512
• FlyBaseID: FBgn0262112
• Length: 335
• Species: Drosophila melanogaster
• Sequence 2: NP_032315.2
• Gene: Hsd11b2 / 15484
• MGIID: 104720
• Length: 386
• Species: Mus musculus
• Alignment Length: 356
• Identity: 100/356 - (28%)
• Similarity: 148/356 - (41%)
• Gaps: 78/356 - (21%)

  Fly     6 LLRALRRSLGLGR-------------------------------------------QQLKVDSRH 27
            ||:.||..|.|||                                           .:|.|.:|
Mouse    20 LLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATR- 83

  Fly    28 VVLITGCDSGLGHSMAVYCHESLHMTVISCCHNIKSEGAKLLQGLASAKDGLSRMHTLELDLLEP 92
            .|||||||:|.|...|... :::..||::...::.|.||..|:.|.|     .|:..|::||.:.
Mouse    84 AVLITGCDTGFGKETAKKL-DAMGFTVLATVLDLNSPGALELRDLCS-----PRLKLLQMDLTKA 142

  Fly    93 DSIRLVHRQLRDILAKDPSYRLTALINNAGV-MCFGEFEWQLTEQIEAQINCNLLGTMRLTHELL 156
            :.|   .|.|....|...|..|..|:||||: :...:.|..........:..|..|.:.||..||
Mouse   143 EDI---SRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLL 204

  Fly   157 PLLRQQQGRIINVTSHCGLQALPALGPYAASKAALRFWTDSLRVELQQYGMEVVNFIPGSFVLDS 221
            ||||..:|||:.|.|..|....|.|..|..||||:....|:...||..:|::|....||.|..|:
Mouse   205 PLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDA 269

  Fly   222 ----NIAARQQQ--HAQKMREAFSAEQHALY-DTYFEAFNG-YLKVLSGFKPPNRLRNESLLAKF 278
                |:..:::|  .|...||...|     | :.|.|..:| :|..|....|......::::
Mouse   270 VTNVNLWEKRKQLLLANIPRELLQA-----YGEDYIEHVHGQFLNSLRMALPDLSPVVDAII--- 326

  Fly   279 KDALTSSQPLALYIEEPRR-----YRLYRWL 304
             |||.::||.:.|.  |.|     |.::.:|
Mouse   327 -DALLAAQPRSRYY--PGRGLGLMYFIHHYL 354

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sro	NP_651725.1	17beta-HSD-like_SDR_c	27..300	CDD:187632	88/286 (31%)
Hsd11b2	NP_032315.2	type2_17beta_HSD-like_SDR_c	83..363	CDD:187665	90/293 (31%)