DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sro and DHRS9

DIOPT Version :9

Sequence 1:	NP_651725.1	Gene:	sro / 43512	FlyBaseID:	FBgn0262112	Length:	335	Species:	Drosophila melanogaster
Sequence 2:	NP_001276692.1	Gene:	DHRS9 / 10170	HGNCID:	16888	Length:	379	Species:	Homo sapiens

Alignment Length:	308	Identity:	87/308 - (28%)
Similarity:	149/308 - (48%)	Gaps:	28/308 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 QLKVD--SRHVVLITGCDSGLGHSMA-VYCHESLHMTVISCCHNIKSEGAKLLQGLASAKDGLSR 81
            :||::  :...:.|||||||.|:..| .:..:..|  ||:.|  :...|:..|:...|     .|
Human    81 KLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFH--VIAAC--LTESGSTALKAETS-----ER 136

  Fly    82 MHTLELDLLEPDSIRLVHRQLRDILAKDPSYRLTALINNAGVM-CFGEFEWQLTEQIEAQINCNL 145
            :.|:.||:.:|::::...:.:::.:.:.   .|..|||||||. .....:|...|.....|..||
Human   137 LRTVLLDVTDPENVKRTAQWVKNQVGEK---GLWGLINNAGVPGVLAPTDWLTLEDYREPIEVNL 198

  Fly   146 LGTMRLTHELLPLLRQQQGRIINVTSHCGLQALPALGPYAASKAALRFWTDSLRVELQQYGMEVV 210
            .|.:.:|..:|||:::.|||:|||:|..|..|:.. |.|..||.|:..:.||||.:::.:|:.|.
Human   199 FGLISVTLNMLPLVKKAQGRVINVSSVGGRLAIVG-GGYTPSKYAVEGFNDSLRRDMKAFGVHVS 262

  Fly   211 NFIPGSFVLDSNIAARQQQHAQKMR--EAFSAEQHALY-DTYFEAFNGYLKVLSGFKPPNRLRNE 272
            ...||.|  .:|:|...:...:|:.  |..|.:....| :.|.|.   .|..|.|.|....:...
Human   263 CIEPGLF--KTNLADPVKVIEKKLAIWEQLSPDIKQQYGEGYIEK---SLDKLKGNKSYVNMDLS 322

  Fly   273 SLLAKFKDALTSSQPLALYIEEPRRYRLYRWL-FTLCPTPLVDWLTVR 319
            .::.....||||..|...| ...:..::: |: .:..|..|.|:|.::
Human   323 PVVECMDHALTSLFPKTHY-AAGKDAKIF-WIPLSHMPAALQDFLLLK 368

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sro	NP_651725.1	17beta-HSD-like_SDR_c	27..300	CDD:187632	80/277 (29%)
sro	NP_651725.1	adh_short	28..229	CDD:278532	64/202 (32%)
DHRS9	NP_001276692.1	type2_17beta_HSD-like_SDR_c	90..366	CDD:187665	84/295 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1610
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D370032at33208
OrthoFinder	1	1.000	-	-		FOG0000161
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X110
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.820