DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IntS11 and YSH1

DIOPT Version :9

Sequence 1:	NP_651721.1	Gene:	IntS11 / 43506	FlyBaseID:	FBgn0039691	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	NP_013379.1	Gene:	YSH1 / 850983	SGDID:	S000004267	Length:	779	Species:	Saccharomyces cerevisiae

Alignment Length:	696	Identity:	197/696 - (28%)
Similarity:	322/696 - (46%)	Gaps:	145/696 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KITPLGAGQDVGRSCLLLSMGGKNIMLDCGMHMGYNDERRFP---DFSYIVPEGPITSHIDCVII 66
            |...||...:|||||.:|...||.:|||.|:|..|......|   :|.        .|.:|.::|
Yeast    10 KFFSLGGSNEVGRSCHILQYKGKTVMLDAGIHPAYQGLASLPFYDEFD--------LSKVDILLI 66

  Fly    67 SHFHLDHCGALPYMSEIVGYTGPIYMTHPTKAIAPILLEDMRKVAVERKGESN---------FFT 122
            |||||||..:|||:.:...:.|.::||||||||...||.|.  |.|...|.|:         .|:
Yeast    67 SHFHLDHAASLPYVMQRTNFQGRVFMTHPTKAIYRWLLRDF--VRVTSIGSSSSSMGTKDEGLFS 129

  Fly   123 TQMIKDCMKKVIPVTLHQSMMVDTDLEIKAYYAGHVLGAAMFWIKVGSQSVVYTGDYNMTPDRHL 187
            .:.:.|...|:..|..|.::.|: .::..|::||||||||||.|::....|::||||:...||||
Yeast   130 DEDLVDSFDKIETVDYHSTVDVN-GIKFTAFHAGHVLGAAMFQIEIAGLRVLFTGDYSREVDRHL 193

  Fly   188 GAAWIDKCRPDLLISESTYATTIRDSKRCRERDFLKKVHECVAKGGKVLIPVFALGRAQELCILL 252
            .:|.:.....::||.|||:.|...:.:..|||...:.:|..|.:||:||:||||||||||:.::|
Yeast   194 NSAEVPPLSSNVLIVESTFGTATHEPRLNRERKLTQLIHSTVMRGGRVLLPVFALGRAQEIMLIL 258

  Fly   253 ETYW-----ERMNLKYPIYFALGLTEKANTYYKMFITWTNQKIRKTF--VHRNMFDFKHIKPFDK 310
            :.||     |....:.||::|..|.:|..:.::.::...|..|||.|  ...|.|.||:|
Yeast   259 DEYWSQHADELGGGQVPIFYASNLAKKCMSVFQTYVNMMNDDIRKKFRDSQTNPFIFKNI----- 318

  Fly   311 AYIDNP------GAMVVFATPGMLHAGLSLQIFKKWAPNENNMVIMPGYCVQGTVGNKILGGAKK 369
            :|:.|.      |..|:.|:||||.:|||..:.::|.|.:.|:|::.||.::||:...|:.....
Yeast   319 SYLRNLEDFQDFGPSVMLASPGMLQSGLSRDLLERWCPEDKNLVLITGYSIEGTMAKFIMLEPDT 383

  Fly   370 VEFENRQVVEV--KMAVEYMSFSAHADAKGIMQLIQNCEPKNVMLVHGEAGKMKFLRSKIKDEF- 431
            :...|...:.:  :..||.:||:||.|.:..::.|:.....|::||||||..|..|:|.:...|
Yeast   384 IPSINNPEITIPRRCQVEEISFAAHVDFQENLEFIEKISAPNIILVHGEANPMGRLKSALLSNFA 448

  Fly   432 -------NLETYMPANGETCV-------------------------ISTPVKIPVDASVSLLKAE 464
                   .:..:.|.|   ||                         .:..:|..:.|.:..:|.|
Yeast   449 SLKGTDNEVHVFNPRN---CVEVDLEFQGVKVAKAVGNIVNEIYKEENVEIKEEIAAKIEPIKEE 510

  Fly   465 ARSYNAQPPDPKRRR-----------LIHGVLVMKDNRIMLQNLTDALKEIGINRHVMRFTSKVK 518
                |....|.:..:           ::.|:||..|....|    |.|....:..|        .
Yeast   511 ----NEDNLDSQAEKGLVDEEEHKDIVVSGILVSDDKNFEL----DFLSLSDLREH--------H 559

  Fly   519 MDDSGPVIRTSERLKTLLEEKLAGWTV--------TMQENGSIAIESVEVKVEEDEKDPKQKNI- 574
            .|.|..::|..:.::...:::|..|.:        .:|::..:.  :.|.||:|:.||    |:
Yeast   560 PDLSTTILRERQSVRVNCKKELIYWHILQMFGEAEVLQDDDRVT--NQEPKVKEESKD----NLT 618

  Fly   575 ----------------------LISWTN--QDEDIGAYILNVLQNM 596
                                  ::.||.  .::.:...|:.:|.|:
Yeast   619 NTGKLILQIMGDIKLTIVNTLAVVEWTQDLMNDTVADSIIAILMNV 664

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IntS11	NP_651721.1	YSH1	4..446	CDD:224157	165/500 (33%)
		INTS11-like_MBL-fold	6..204	CDD:293849	77/209 (37%)
		Beta-Casp	245..363	CDD:214983	42/130 (32%)
		RMMBL	376..416	CDD:284853	12/41 (29%)
YSH1	NP_013379.1	YSH1	9..470	CDD:224157	165/478 (35%)
YSH1	NP_013379.1	CPSF73-100_C	533..777	CDD:403042	26/150 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1236
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53735
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820