Protein Alignment IntS11 and INTS9

DIOPT Version :10

• Sequence 1: NP_651721.1
• Gene: IntS11 / 43506
• FlyBaseID: FBgn0039691
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_001349967.1
• Gene: INTS9 / 55756
• HGNCID: 25592
• Length: 676
• Species: Homo sapiens
• Alignment Length: 699
• Identity: 145/699 - (20%)
• Similarity: 240/699 - (34%)
• Gaps: 215/699 - (30%)

  Fly    19 CLLLSMGGKNIMLDCGMHM---------------------GYN--DERRFPD----------FSY 50
            |.:|......||||||:.|                     |::  |...|.|          |..
Human    14 CNVLKFKSTTIMLDCGLDMTSTLNFLPLPLVQSPRLSNLPGWSLKDGNAFLDKELKECSGHVFVD 78

  Fly    51 IVPEG--PIT-----SHIDCVIISHFHLDHC-GALPYMSEIVGYTGPIYMTHPTKAIAPILLEDM 107
            .|||.  |.|     |.:|.::||::   || .||||::|..|:||.:|.|.||..|..:|:|::
Human    79 SVPEFCLPETELIDLSTVDVILISNY---HCMMALPYITEHTGFTGTVYATEPTVQIGRLLMEEL 140

  Fly   108 ----------------------------RKVAVERKGESNFFTTQMIKDCMKKVIPVTLHQSMMV 144
                                        .|.|||.......:|.|.:...:.|:..|...|.:.:
Human   141 VNFIERVPKAQSASLWKNKDIQRLLPSPLKDAVEVSTWRRCYTMQEVNSALSKIQLVGYSQKIEL 205

  Fly   145 DTDLEIKAYYAGHVLGAAMFWIKVGSQSVVY-TGDYNMTPDRH---------------LGAAWID 193
            ...:::....:|:.||::.:.|:...:.|.| :|...:|....               .|...|.
Human   206 FGAVQVTPLSSGYALGSSNWIIQSHYEKVSYVSGSSLLTTHPQPMDQASLKNSDVLVLTGLTQIP 270

  Fly   194 KCRPDLLISE--STYATTIRDSKRCRERDFLKKVHECVAKGGKVLIPVFALGRAQELCILLETYW 256
            ...||.::.|  |..|.|:|:                   ||.||:|.:..|...:|...|..|.
Human   271 TANPDGMVGEFCSNLALTVRN-------------------GGNVLVPCYPSGVIYDLLECLYQYI 316

  Fly   257 ERMNL-KYPIYFALGLTEKANTYYKMFITW-TNQKIRKT------FVHRNMFDFKHIKPFDKAYI 313
            :...| ..|:||...:...:..:.::|..| .:.|..|.      |.|..:.....:|.:...:.
Human   317 DSAGLSSVPLYFISPVANSSLEFSQIFAEWLCHNKQSKVYLPEPPFPHAELIQTNKLKHYPSIHG 381

  Fly   314 D------NPGAMVVFATPGMLHAGLSLQIFKKWAPNENNMVIMPG-------------------- 352
            |      .|  .|||.....|..|..:...:.|..:..|.||...
Human   382 DFSNDFRQP--CVVFTGHPSLRFGDVVHFMELWGKSSLNTVIFTEPDFSYLEALAPYQPLAMKCI 444

  Fly   353 YCVQGTVGNKILGGAKKVEFENRQVVEVKMAVEYMSFSAHADAKGIMQLIQNCEPKNVMLVHGEA 417
            ||...|..|.|.......|.:...||..:...:.....:|.     |.|:.:|:|..:.....|.
Human   445 YCPIDTRLNFIQVSKLLKEVQPLHVVCPEQYTQPPPAQSHR-----MDLMIDCQPPAMSYRRAEV 504

  Fly   418 GKMKFLRSKIKDEFNLETYMPANGETCVISTPVKIPVDASVSLLKAEARSYNAQ-----PPDP-- 475
            ..:.|.|...|.|.     ||...::.|   |::|....|::.:.|...:.:.:     ||.|
Human   505 LALPFKRRYEKIEI-----MPELADSLV---PMEIKPGISLATVSAVLHTKDNKHLLQPPPRPAQ 561

  Fly   476 -----KRRRLIHGV---LVMK---DNRIMLQNLTDALKEIG-------------INRHVMRFTSK 516
                 ||:|:...|   .|:|   ...|.::.....|::|.             :.:|..   |.
Human   562 PTSGKKRKRVSDDVPDCKVLKPLLSGSIPVEQFVQTLEKISQMCSLPSPPLSFLLEQHGF---SD 623

  Fly   517 VKMDDSGPVIRTSERLKTLLEEKLAGWTVTMQENGSIAIESVEVKVEED 565
            :|::|:.                 .|..|.:||..::      :::|||
Human   624 IKVEDTA-----------------KGHIVLLQEAETL------IQIEED 649

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IntS11	NP_651721.1	YSH1	5..416	CDD:440849	110/517 (21%)
		INTS11-like_MBL-fold	6..204	CDD:293849	62/271 (23%)
INTS9	NP_001349967.1	Int9-like_MBL-fold	1..265	CDD:293852	57/253 (23%)
		Beta-Casp	307..425	CDD:214983	25/119 (21%)