Protein Alignment IntS11 and INTS11

DIOPT Version :10

• Sequence 1: NP_651721.1
• Gene: IntS11 / 43506
• FlyBaseID: FBgn0039691
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: XP_011539949.1
• Gene: INTS11 / 54973
• HGNCID: 26052
• Length: 660
• Species: Homo sapiens
• Alignment Length: 587
• Identity: 403/587 - (68%)
• Similarity: 479/587 - (81%)
• Gaps: 6/587 - (1%)

  Fly    10 GAGQDVGRSCLLLSMGGKNIMLDCGMHMGYNDERRFPDFSYIVPEGPITSHIDCVIISHFHLDHC 74
            ||||||||||:|:|:.|||:|||||||||:||:|||||||||...|.:|..:|||||||||||||
Human    70 GAGQDVGRSCILVSIAGKNVMLDCGMHMGFNDDRRFPDFSYITQNGRLTDFLDCVIISHFHLDHC 134

  Fly    75 GALPYMSEIVGYTGPIYMTHPTKAIAPILLEDMRKVAVERKGESNFFTTQMIKDCMKKVIPVTLH 139
            |||||.||:|||.|||||||||:||.||||||.||:||::|||:||||:||||||||||:.|.||
Human   135 GALPYFSEMVGYDGPIYMTHPTQAICPILLEDYRKIAVDKKGEANFFTSQMIKDCMKKVVAVHLH 199

  Fly   140 QSMMVDTDLEIKAYYAGHVLGAAMFWIKVGSQSVVYTGDYNMTPDRHLGAAWIDKCRPDLLISES 204
            |::.||.:|||||||||||||||||.|||||:||||||||||||||||||||||||||:|||:||
Human   200 QTVQVDDELEIKAYYAGHVLGAAMFQIKVGSESVVYTGDYNMTPDRHLGAAWIDKCRPNLLITES 264

  Fly   205 TYATTIRDSKRCRERDFLKKVHECVAKGGKVLIPVFALGRAQELCILLETYWERMNLKYPIYFAL 269
            |||||||||||||||||||||||.|.:|||||||||||||||||||||||:|||||||.||||:.
Human   265 TYATTIRDSKRCRERDFLKKVHETVERGGKVLIPVFALGRAQELCILLETFWERMNLKVPIYFST 329

  Fly   270 GLTEKANTYYKMFITWTNQKIRKTFVHRNMFDFKHIKPFDKAYIDNPGAMVVFATPGMLHAGLSL 334
            |||||||.|||:||.|||||||||||.||||:|||||.||:|:.||||.|||||||||||||.||
Human   330 GLTEKANHYYKLFIPWTNQKIRKTFVQRNMFEFKHIKAFDRAFADNPGPMVVFATPGMLHAGQSL 394

  Fly   335 QIFKKWAPNENNMVIMPGYCVQGTVGNKILGGAKKVEFENRQVVEVKMAVEYMSFSAHADAKGIM 399
            |||:|||.||.|||||||||||||||:|||.|.:|:|.|.|||:||||.||||||||||||||||
Human   395 QIFRKWAGNEKNMVIMPGYCVQGTVGHKILSGQRKLEMEGRQVLEVKMQVEYMSFSAHADAKGIM 459

  Fly   400 QLIQNCEPKNVMLVHGEAGKMKFLRSKIKDEFNLETYMPANGETCVISTPVKIPVDASVSLLKAE 464
            ||:...||::|:||||||.||:||:.||:.|..:..||||||||..:.|...|||..|:.|||.|
Human   460 QLVGQAEPESVLLVHGEAKKMEFLKQKIEQELRVNCYMPANGETVTLPTSPSIPVGISLGLLKRE 524

  Fly   465 ARSYNAQP--PDPKRRRLIHGVLVMKDNRIMLQNLTDALKEIGINRHVMRFTSKVKMDDSGPVIR 527
            .    ||.  |:.|:.||:||.|:|||:...|.:...||||:|:..|.:|||.:|.:.|:.....
Human   525 M----AQGLLPEAKKPRLLHGTLIMKDSNFRLVSSEQALKELGLAEHQLRFTCRVHLHDTRKEQE 585

  Fly   528 TSERLKTLLEEKLAGWTVTMQENGSIAIESVEVKVEEDEKDPKQKNILISWTNQDEDIGAYILNV 592
            |:.|:.:.|:..|....|....:||:.:|||.::.....:||..|.:|:|||.|||::|:::.::
Human   586 TALRVYSHLKSVLKDHCVQHLPDGSVTVESVLLQAAAPSEDPGTKVLLVSWTYQDEELGSFLTSL 650

  Fly   593 LQ 594
            |:
Human   651 LK 652

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IntS11	NP_651721.1	YSH1	5..416	CDD:440849	330/405 (81%)
		INTS11-like_MBL-fold	6..204	CDD:293849	155/193 (80%)
INTS11	XP_011539949.1	COG1782	69..506	CDD:441388	348/435 (80%)
		INTS11-like_MBL-fold	70..264	CDD:293849	155/193 (80%)