Protein Alignment IntS11 and Cpsf3

DIOPT Version :10

• Sequence 1: NP_651721.1
• Gene: IntS11 / 43506
• FlyBaseID: FBgn0039691
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_061283.2
• Gene: Cpsf3 / 54451
• MGIID: 1859328
• Length: 684
• Species: Mus musculus
• Alignment Length: 608
• Identity: 215/608 - (35%)
• Similarity: 323/608 - (53%)
• Gaps: 72/608 - (11%)

  Fly     6 ITPLGAGQDVGRSCLLLSMGGKNIMLDCGMHMGYNDERRFPDFSYIVPEGPITSHIDCVIISHFH 70
            |.||||||:|||||::|...|:.||||||:|.|.......|....|.|     :.||.::|||||
Mouse    14 IRPLGAGQEVGRSCIILEFKGRKIMLDCGIHPGLEGMDALPYIDLIDP-----AEIDLLLISHFH 73

  Fly    71 LDHCGALPYMSEIVGYTGPIYMTHPTKAIAPILLEDMRKVAVERKGESNFFTTQMIKDCMKKVIP 135
            ||||||||:..:...:.|..:|||.||||...||.|..||: ....:...:|...:::.|.|:..
Mouse    74 LDHCGALPWFLQKTSFKGRTFMTHATKAIYRWLLSDYVKVS-NISADDMLYTETDLEESMDKIET 137

  Fly   136 VTLHQSMMVDTDLEIKAYYAGHVLGAAMFWIKVGSQSVVYTGDYNMTPDRHLGAAWIDKCRPDLL 200
            :..|:...| ..::...|:||||||||||.|::....::||||::...||||.||.|...:||:|
Mouse   138 INFHEVKEV-AGIKFWCYHAGHVLGAAMFMIEIAGVKLLYTGDFSRQEDRHLMAAEIPNIKPDIL 201

  Fly   201 ISESTYATTIRDSKRCRERDFLKKVHECVAKGGKVLIPVFALGRAQELCILLETYWERMNLKY-- 263
            |.||||.|.|.:.:..||..|...||:.|.:||:.|||||||||||||.::|:.||:.....:
Mouse   202 IIESTYGTHIHEKREEREARFCNTVHDIVNRGGRGLIPVFALGRAQELLLILDEYWQNHPELHDI 266

  Fly   264 PIYFALGLTEKANTYYKMFITWTNQKIRKTFVHRNMFDFKHI---KPFDKAYIDNPGAMVVFATP 325
            |||:|..|.:|....|:.::...|.||||.....|.|.||||   |..|  :.|:.|..||.|:|
Mouse   267 PIYYASSLAKKCMAVYQTYVNAMNDKIRKQININNPFVFKHISNLKSMD--HFDDIGPSVVMASP 329

  Fly   326 GMLHAGLSLQIFKKWAPNENNMVIMPGYCVQGTVGNKILGGAKKVEFENRQVVEVKMAVEYMSFS 390
            ||:..|||.::|:.|..::.|.||:.||||:||:...|:...:::...:.|.:.:||:|:|:|||
Mouse   330 GMIQNGLSRELFESWCTDKRNGVIIAGYCVEGTLAKHIMSEPEEITTMSGQKLPLKMSVDYISFS 394

  Fly   391 AHADAKGIMQLIQNCEPKNVMLVHGEAGKMKFLRSKI------KDEFNLETYMPANGETCVIS-T 448
            ||.|.:...:.|:..:|.:|:|||||..:|..|::.:      .||.::|.:.|.|.|...:: .
Mouse   395 AHTDYQQTSEFIRALKPPHVILVHGEQNEMARLKAALIREYEDNDEVHIEVHNPRNTEAVTLNFR 459

  Fly   449 PVKIPVDASVSLLKAEARSYNAQPPDPKRRRLIHGVLVMKD------NRIMLQNLTDALKEIGIN 507
            ..|:   |.|....|:.:        |::.:.:.|:||.::      :...|.|.||........
Mouse   460 GEKL---AKVMGFLADKK--------PEQGQRVSGILVKRNFNYHILSPCDLSNYTDLAMSTVKQ 513

  Fly   508 RHVMRFTSKVKMDDSGPVIRTSERLKTL--------LEEKLA-----GWTVTMQENGSIAIE--- 556
            ...:.:|        ||......:|:.|        ::||.|     ..|| :||.|.:.:|
Mouse   514 TQAIPYT--------GPFYLLYYQLQKLTGDVEELEIQEKPALKVFKSITV-VQEPGMVVLEWLA 569

  Fly   557 ---------SVEVKVEEDEKDPK 570
                     :|...:.|.:.:||
Mouse   570 NPSNDMYADTVTTVILEVQSNPK 592

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IntS11	NP_651721.1	YSH1	5..416	CDD:440849	175/414 (42%)
		INTS11-like_MBL-fold	6..204	CDD:293849	85/197 (43%)
Cpsf3	NP_061283.2	CPSF3-like_MBL-fold	12..205	CDD:293850	85/197 (43%)
		YSH1	14..421	CDD:440849	176/415 (42%)
		CPSF73-100_C	479..682	CDD:463330	25/123 (20%)