Protein Alignment IntS11 and CPSF2

DIOPT Version :10

• Sequence 1: NP_651721.1
• Gene: IntS11 / 43506
• FlyBaseID: FBgn0039691
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_059133.1
• Gene: CPSF2 / 53981
• HGNCID: 2325
• Length: 782
• Species: Homo sapiens
• Alignment Length: 735
• Identity: 157/735 - (21%)
• Similarity: 255/735 - (34%)
• Gaps: 244/735 - (33%)

  Fly     4 IKITPLGAGQDVGRSCLLLSMGGKNIMLDCGMHMGYNDERRFPDFSYIVPEGPITSH---IDCVI 65
            ||:|.|...|:....|.||.:.....:||||.     ||.    ||..:.:. :..|   ||.|:
Human     5 IKLTTLSGVQEESALCYLLQVDEFRFLLDCGW-----DEH----FSMDIIDS-LRKHVHQIDAVL 59

  Fly    66 ISHFHLDHCGALPYMSEIVGYTGPIYMTHPTKAIAPILLEDMRKVAVERKGESNF--FTTQMIKD 128
            :||....|.|||||....:|....||.|.|...:..:.:.|:.:   .|....:|  ||...:..
Human    60 LSHPDPLHLGALPYAVGKLGLNCAIYATIPVYKMGQMFMYDLYQ---SRHNTEDFTLFTLDDVDA 121

  Fly   129 CMKKVIPVTLHQSMMV---DTDLEIKAYYAGHVLGAAMFW--IKVGSQSVVYTGDYNMTPDRHLG 188
            ...|:..:...|.:.:   ...|.|....|||::|..: |  :|.|.:.:||..|:|...:.||.
Human   122 AFDKIQQLKFSQIVNLKGKGHGLSITPLPAGHMIGGTI-WKIVKDGEEEIVYAVDFNHKREIHLN 185

  Fly   189 AAWIDK-CRPDLLISESTYATTIRDSKRCRERDFLKKVHECVAKGGKVLIPVFALGRAQELCILL 252
            ...::. .||.|||::|..||.::..::.|:...|..|.|.:...|.|||.|...||..||..||
Human   186 GCSLEMLSRPSLLITDSFNATYVQPRRKQRDEQLLTNVLETLRGDGNVLIAVDTAGRVLELAQLL 250

  Fly   253 ETYWERMNLKYPIYFALGLTEKAN----TYYKMFITWTNQKIRKTFVHR--NMFDFKHIK----P 307
            :..|...:....:| :|.|....:    .:.|..:.|.:.|:.:.|..:  |.|.|:|:.    .
Human   251 DQIWRTKDAGLGVY-SLALLNNVSYNVVEFSKSQVEWMSDKLMRCFEDKRNNPFQFRHLSLCHGL 314

  Fly   308 FDKAYIDNPGAMVVFATPGMLHAGLSLQIFKKWAPNENNMVIM-----PGYCVQGTVGN------ 361
            .|.|.:.:|  .||.|:...|..|.|..:|.:|..:..|.:|:     ||...:..:.|
Human   315 SDLARVPSP--KVVLASQPDLECGFSRDLFIQWCQDPKNSIILTYRTTPGTLARFLIDNPSEKIT 377

  Fly   362 --------KILG---------------GAKKVE-------------------------------- 371
                    |:.|               .|||:|
Human   378 EIELRKRVKLEGKELEEYLEKEKLKKEAAKKLEQSKEADIDSSDESDIEEDIDQPSAHKTKHDLM 442

  Fly   372 ----------------------------------------------------------------- 371
                                                                             
Human   443 MKGEGSRKGSFFKQAKKSYPMFPAPEERIKWDEYGEIIKPEDFLVPELQATEEEKSKLESGLTNG 507

  Fly   372 ---------------FENRQVVEVKMAVEYMSFSAHADAKGIMQLIQNCEPKNVMLVHG--EA-- 417
                           ....:.:|:|..|.|:.:...:|...|.::|...:|:.:::|||  ||
Human   508 DEPMDQDLSDVPTKCISTTESIEIKARVTYIDYEGRSDGDSIKKIINQMKPRQLIIVHGPPEASQ 572

  Fly   418 ----------GKMKFLRSKIKDEFNLETYMP-------ANGETCVISTPVKIPVDASVSLLKAEA 465
                      ||            :::.|||       |..||.:....:|..:.:|:...||
Human   573 DLAECCRAFGGK------------DIKVYMPKLHETVDATSETHIYQVRLKDSLVSSLQFCKA-- 623

  Fly   466 RSYNAQPPDPKRRRL--IHGVLVMK----DNRIMLQNLTDALKEIGINRHVMRFTSKVKMDDSGP 524
                      |...|  |.|||.|:    |..::|:.  ..||:.|.:..:     :|:......
Human   624 ----------KDAELAWIDGVLDMRVSKVDTGVILEE--GELKDDGEDSEM-----QVEAPSDSS 671

  Fly   525 VIRTSERLKTLL--EEKLAG 542
            ||...:.:|:|.  :||..|
Human   672 VIAQQKAMKSLFGDDEKETG 691

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IntS11	NP_651721.1	YSH1	5..416	CDD:440849	122/579 (21%)
		INTS11-like_MBL-fold	6..204	CDD:293849	58/208 (28%)
CPSF2	NP_059133.1	CPSF2-like_MBL-fold	7..204	CDD:293851	59/210 (28%)
		Beta-Casp	243..368	CDD:214983	31/127 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	407..449		3/41 (7%)
		RMMBL	528..591	CDD:462191	16/74 (22%)
		CPSF100_C	608..779	CDD:463836	24/103 (23%)