Protein Alignment IntS11 and CPSF3

DIOPT Version :10

• Sequence 1: NP_651721.1
• Gene: IntS11 / 43506
• FlyBaseID: FBgn0039691
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_001308765.1
• Gene: CPSF3 / 51692
• HGNCID: 2326
• Length: 688
• Species: Homo sapiens
• Alignment Length: 604
• Identity: 212/604 - (35%)
• Similarity: 321/604 - (53%)
• Gaps: 72/604 - (11%)

  Fly    10 GAGQDVGRSCLLLSMGGKNIMLDCGMHMGYNDERRFPDFSYIVPEGPITSHIDCVIISHFHLDHC 74
            ||||:|||||::|...|:.||||||:|.|.......|....|.|     :.||.::|||||||||
Human    22 GAGQEVGRSCIILEFKGRKIMLDCGIHPGLEGMDALPYIDLIDP-----AEIDLLLISHFHLDHC 81

  Fly    75 GALPYMSEIVGYTGPIYMTHPTKAIAPILLEDMRKVAVERKGESNFFTTQMIKDCMKKVIPVTLH 139
            ||||:..:...:.|..:|||.||||...||.|..||: ....:...:|...:::.|.|:..:..|
Human    82 GALPWFLQKTSFKGRTFMTHATKAIYRWLLSDYVKVS-NISADDMLYTETDLEESMDKIETINFH 145

  Fly   140 QSMMVDTDLEIKAYYAGHVLGAAMFWIKVGSQSVVYTGDYNMTPDRHLGAAWIDKCRPDLLISES 204
            :...| ..::...|:||||||||||.|::....::||||::...||||.||.|...:||:||.||
Human   146 EVKEV-AGIKFWCYHAGHVLGAAMFMIEIAGVKLLYTGDFSRQEDRHLMAAEIPNIKPDILIIES 209

  Fly   205 TYATTIRDSKRCRERDFLKKVHECVAKGGKVLIPVFALGRAQELCILLETYWERMNLKY--PIYF 267
            ||.|.|.:.:..||..|...||:.|.:||:.|||||||||||||.::|:.||:.....:  |||:
Human   210 TYGTHIHEKREEREARFCNTVHDIVNRGGRGLIPVFALGRAQELLLILDEYWQNHPELHDIPIYY 274

  Fly   268 ALGLTEKANTYYKMFITWTNQKIRKTFVHRNMFDFKHI---KPFDKAYIDNPGAMVVFATPGMLH 329
            |..|.:|....|:.::...|.||||.....|.|.||||   |..|  :.|:.|..||.|:|||:.
Human   275 ASSLAKKCMAVYQTYVNAMNDKIRKQININNPFVFKHISNLKSMD--HFDDIGPSVVMASPGMMQ 337

  Fly   330 AGLSLQIFKKWAPNENNMVIMPGYCVQGTVGNKILGGAKKVEFENRQVVEVKMAVEYMSFSAHAD 394
            :|||.::|:.|..::.|.||:.||||:||:...|:...:::...:.|.:.:||:|:|:|||||.|
Human   338 SGLSRELFESWCTDKRNGVIIAGYCVEGTLAKHIMSEPEEITTMSGQKLPLKMSVDYISFSAHTD 402

  Fly   395 AKGIMQLIQNCEPKNVMLVHGEAGKMKFLRSKI------KDEFNLETYMPANGETCVIS-TPVKI 452
            .:...:.|:..:|.:|:|||||..:|..|::.:      .||.::|.:.|.|.|...:: ...|:
Human   403 YQQTSEFIRALKPPHVILVHGEQNEMARLKAALIREYEDNDEVHIEVHNPRNTEAVTLNFRGEKL 467

  Fly   453 PVDASVSLLKAEARSYNAQPPDPKRRRLIHGVLVMKD------NRIMLQNLTDALKEIGINRHVM 511
               |.|....|:.:        |::.:.:.|:||.::      :...|.|.||...........:
Human   468 ---AKVMGFLADKK--------PEQGQRVSGILVKRNFNYHILSPCDLSNYTDLAMSTVKQTQAI 521

  Fly   512 RFTSKVKMDDSGPVIRTSERLKTL--------LEEKLA-----GWTVTMQENGSIAIE------- 556
            .:|        ||......:|:.|        ::||.|     ..|| :||.|.:.:|
Human   522 PYT--------GPFNLLCYQLQKLTGDVEELEIQEKPALKVFKNITV-IQEPGMVVLEWLANPSN 577

  Fly   557 -----SVEVKVEEDEKDPK 570
                 :|...:.|.:.:||
Human   578 DMYADTVTTVILEVQSNPK 596

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IntS11	NP_651721.1	YSH1	5..416	CDD:440849	172/410 (42%)
		INTS11-like_MBL-fold	6..204	CDD:293849	82/193 (42%)
CPSF3	NP_001308765.1	COG1782	18..460	CDD:441388	182/446 (41%)
		CPSF3-like_MBL-fold	22..209	CDD:293850	82/193 (42%)
		CPSF73-100_C	483..686	CDD:463330	25/123 (20%)